University of Illinois at Chicago
College of Medicine
DEPARTMENT of MOLECULAR GENETICS

HUMAN GENETICS for M-1 STUDENTS


INTRODUCTION
  1. Organization of the Course
  2. Required and Optional Texts
  3. General Introduction
MENDELIAN INHERITANCE
  1. General Background
  2. Mitosis and Meiosis
  3. Meiosis and Gametogenesis
  4. Pedigree Construction
  5. Modes of Inheritance
    1. autosomal dominant inheritance
    2. autosomal recessive inheritance
    3. X-linked dominant inheritance
    4. X-linked recessive inheritance
    5. sex limited inheritance
    6. mitochondrial inheritance
  6. Imprinting
CHROMOSOMAL INHERITANCE
  1. Importance
  2. Karyotype
  3. Chromosome Replication
  4. Autosomal Chromosomal Abnormalities
    1. meiotic nondisjunction
    2. mitotic nondisjunction
    3. Robertsonian translocation
    4. isochrome formation
  5. Sex Chromosome Abnormalities
    1. Lyon hypothesis
    2. Barr bodies
    3. Turner syndrome
    4. Klinefelter syndrome
    5. XYY and XXX syndromes
  6. Non-Meiotic Chromosome Abnormalities
    1. Inversions
    2. Ring Chromosomes
    3. Translocations (non-Robertsonian)
    4. Uniparental Disomy
MULTIFACTORIAL INHERITANCE
  1. Importance
  2. Regression to the mean
  3. Polygenic Inheritance
  4. The Multifactorial Model
  5. Concordance
  6. Threshold Model of Disease
  7. Degree of Relationship and Genes in Common
  8. Two Threshold Diseases
  9. Severity of Disease and Recurrence Risk
  10. Multiple Affected Offspring and Recurrence Risk
  11. Consanguinity
  12. Hallmarks of Multifactorial Inheritance
LINKAGE AND MAPPING
  1. Introduction
  2. X-linkage
  3. Autosomal Linkage
POPULATION GENETICS
  1. Introduction
  2. Gene and Genotype Frequencies
    1. Codominant Alleles
    2. Hardy-Weinberg Equilibrium
    3. Exceptions to Hardy-Weinberg Assumptions

Quizzes on the five major topics listed above are available on-line at our secure Mallard site. Click here and the UIC WWW Identification Service will ask for your netid and then your password (these are the same as those you use for email.)

Once the Mallard page loads you can access the quizzes by clicking on the Lessons Page link (also the third icon from the top of the navigation bar) or the Current Lesson link (also the fourth icon from the top of the navigation bar).


Contact Dr. Robert Tissot with questions about the content of these pages.

Contact Dr. Elliot Kaufman, Course Director with questions about the functionality of these pages.

Go to Department of Molecular Genetics homepage. Go to Department of Molecular Genetics homepage.