REVIEW PROBLEMS : Clearance-1
Question 1:
Complete the table. For the effect stated in column 1, state the effect (increase,
decrease or no change) on the pharmacokinetic parameters of a high extraction
ratio drug.
For IV bolus |
|||
EFFECT |
CL |
Vd |
t½ |
| ¯ QH |
|||
| ¯ CLint |
|||
| ¯ fub |
|||
| ¯ fut |
|||
For IV infusion |
||
EFFECT |
Time to ss |
Cpss |
| ¯ QH |
||
| ¯ CLint |
||
| ¯ fub |
||
| ¯ fut |
||
For Oral Dose |
||
EFFECT |
FH |
AUC |
| ¯ QH |
||
| ¯ CLint |
||
| ¯ fub |
||
| ¯ fut |
||
Last Updated:
10/15/99
Designed and Created By:
Gayatri Srinivasaraghavan
Vineet Grover
Helen Kastrissios
Supported by a grant from The Center For Excellence in Teaching and Learning, UIC.