1.
REVIEW PROBLEMS : IV bolus - 1
Problem Set 1
Part I. Unit Conversion Practice
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Part II. Intravenous (IV) Bolus
A patient receives a 100 mg intravenous injection of a drug. Plasma drug concentrations are measured for a period of 24 hours after the dose, and are as follows:
Time (h) |
Plasma Concentration ( mg/ml) |
0.5 |
9.2 |
1 |
8.4 |
2 |
7.1 |
4 |
5.0 |
8 |
2.5 |
12 |
1.3 |
24 |
0.2 |
Please note: Double click in order to join two points on the graph.
Calculate the elimination rate constant (k), plasma half-life (t1/2), volume of distribution (Vd), clearance (CL) and area under the curve from 0 to infinity.
1. Calculation for slope of the terminal portion of the curve, k:
2. Calculation for half-life, t1/2:
3. Calculation for Vd:
4. Calculation for CL
5. Calculation for AUC (0 to infinity)
Time (h) |
Plasma Concentration ( mg/ml) |
AUC |
0.5 |
9.2 |
|
1 |
8.4 |
|
2 |
7.1 |
|
4 |
5.0 |
|
8 |
2.5 |
|
12 |
1.3 |
|
24 |
0.2 |
|
Last Updated:
09/14/99
Designed and Created By:
Gayatri Srinivasaraghavan
Vineet Grover
Helen Kastrissios
Supported by a grant from The Center For Excellence in Teaching and Learning, UIC.