REVIEW PROBLEMS :     Dialysis

Question 1

A patient's average gentamicin blood concentration was found to be 50 µg/ml during CAPD lasting 6 hours. The gentamicin concentration in the dialysate was 30 mg/L in a total volume of 1.75 L. What is the peritoneal dialysis clearance of the drug?

Question 2

If the patient's total clearance (CL_TOT) was 15 ml/min while on CAPD, (a) what is the patient's systemic clearance (CL_s) and (b) how much drug was cleared during the 6 hours that the patient was on CAPD?