REVIEW PROBLEMS : IV Bolus - 4
The following plasma concentration vs. time data were collected after administration of a single IV bolus dose of 100 mg drug to a patient:
| Time (h) | Plasma Concentration (mg/ml) |
| 0.25 | 11.85 |
| 0.5 | 11.23 |
| 1 | 10.08 |
| 2 | 8.13 |
| 4 | 5.29 |
| 8 | 2.24 |
| 12 | 0.95 |
| 16 | 0.40 |
a) Plot the data.
b) Calculate the elimination rate constant, half-life and volume of distrubution.
c) Calculate AUC0-infinity
Last Updated:
10/13/99
Designed and Created By:
Gayatri Srinivasaraghavan
Vineet Grover
Helen Kastrissios
Supported by a grant from The Center For Excellence in Teaching and Learning, UIC.