Ans: The most likely precursor for the biosynthesis of bozoamine (hypothetically, of course) is a-methyltyrosine or a-methylphenylalanine. It is converted to the (1R, 2S) a-methylnorepinephrine in the same manner as the biosynthesis of R (-) norepinephrine. (1R, 2S) a-methylnorepinephrine is then methylated by the enzyme COMT to the corresponding methoxy intermediate that is benzylated with a reductase and with the co-substrate of benzaldehyde.