PHAR 408 EXAM ANSWER KEY

1. Cytarabine; 2. Doxorubicin; 3. Cisplatin; 4. Methotrexate; 5. Pentostatin;

6. Temozolomide; 7. Ifosfamide; 8. Callicheamicin; 9. Etoposide; 10. Vincristine;

11. Camptothecin; 12. Taxol.

13. Cl-CH2-CH2-N(-NO)-C(=O)-NH-CH2-CH2-Cl--->

Cl-CH2-CH2-N=N-OH + O=C=N-CH2-CH2-Cl (Carbamoylation)

Cl-CH2-CH2-N=N-OH---> Cl-CH2-CH2(+) + N2 + OH(-) (Alkylation)

14. Selectivity in cytotoxicity assays; Mechanism and enzyme-based bioassays.

15: d; 16: d; 17: b; 18: e; 19: d; 20: d; 21: b; 22: b;

23: c; 24: b; 25: a; 26: c; 27: c; 28: d; 29: a; 30: d.