Cytokines and the regulation of steroidogenesis

Immune factors vs. Cyp17 mRNA

Immune factors vs. Cyp17 mRNA

Immune factors vs. testosterone

IL-6 vs. testosterone production

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Calphostin C vs. AVP inhibition of P450c17 mRNA

MARKS Phosphorylation

Effect of AVP on MARKS phosphorylation

PKC inhibits cAMP-induced P450c17

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Percent of WT induction by cAMP

Putative sites revealed by mutants

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Effect of ATF2 on expression

cAMP vs.ATF2 protein expression

Summary and plans