Publications of Trainees

Publications of Trainees

Representative Publications of Past and Current STTP Trainees

Trainee	Mentor	Publications
Monika Stankiewicz	Ackerman, Steven	Du J, Stankiewicz MJ, Liu Y, Xi Q, Schmitz JE and Ackerman SJ. Novel combinatorial interactions of GATA-1, PU.1 and C/EBP? isoforms regulate transcription of the gene encoding eosinophil granule major basic protein. J. Biol. Chem. 2002; 277:43481-43394. Stankiewicz MJ, Du J, and Ackerman SJ. CCAAT/Enhancer-binding Protein ?27 Antagonism of GATA-1 Transcriptional Activity is Mediated by a Unique Repression Domain, is Independent of Sumoylation, and Does Not Require DNA-Binding. J. Biol. Chem. 2006; submitted.
Jennifer Meagher	Gettins, Peter	Garone, L., Edmunds, T., Hanson, E., Bernasconi, R., Huntington, J.A., Meagher, J.L., Fan, B., and Gettins, P.G.W. (1996) "Antithrombin-heparin affinity reduced by fucosylation of carbohydrate at position 155." Biochemistry 35, 8881-8889. Meagher, J.L., Huntington, J.A., Fan, B., and Gettins, P.G.W. (1996) "Role of arginine 132 and lysine 133 in heparin binding to and activation of antithrombin." J. Biol. Chem. 271, 29353-29358. Meagher, J.L., Beechem, J.M., Olson, S.T., and Gettins, P.G.W. (1998) "Deconvolution of the tryptophan fluorescence spectrum of human antithrombin and identification of the residues that are responsive to heparin binding." J. Biol. Chem. 273, 23283-23289. Meagher, J.L., Olson, S.T., and Gettins, P.G.W. (2000) "Critical role of the linker region between helix D and strand 2A in heparin activation of antithrombin." J. Biol. Chem. 275, 2698-2704.
Michael Risk	Gibori, Geula	Sugino N, Zilberstein M, Srivastava RK, Telleria CM, Nelson SE, Risk M, Chou JY and Gibori G (1998). Establishment and characterization of a simian virus 40-transformed temperature sensitive rat luteal cell line. Endocrinology, 139:1936-1942. Risk M, Shehu A, Mao J, Stocco CS, Goldsmith LT, and Gibori G (2005). Cloning and characterization of a 5' regulatory region of the PRAP/17?HSD7 gene. Endocrinology, In Press. Risk M, Stocco C, Smith CL, Mao J, Puryear T, Rohan R, Azhar S and Gibori G. (2005). Opposite regulation of P450c17 and PRAP/17BHSD/17?: Two Enzymes Involved in estradiol production in the corpus luteum. Endocrinology 146:2807-16.
Nathan Majewski	Hay, Nissim	Majewski, N., Nogueira, V., Bhaskar, P., Coy, P. E., Skeen, J. E., Gottlob, K., Chandel, N. S., Thompson, C. B., Robey, R. B., and Hay, N. (2004a). Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Mol Cell 16, 819-830.
		Majewski, N., Nogueira, V., Robey, R. B., and Hay, N. (2004b). Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases. Mol Cell Biol 24, 730-740.
		Gottlob, K., Majewski, N., Kennedy, S., Kandel, E., Robey, R. B., and Hay, N. (2001). Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes Dev 15, 1406-1418
		Kandel, E. S., Skeen, J., Majewski, N., Di Cristofano, A., Pandolfi, P. P., Feliciano, C. S., Gartel, A., and Hay, N. (2002). Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage. Mol Cell Biol 22, 7831-7841.
		Zazzeroni, F., Papa, S., Algeciras-Schimnich, A., Alvarez, K., Melis, T., Bubici, C., Majewski, N., Hay, N., De Smaele, E., Peter, M. E., and Franzoso, G. (2003). Gadd45 beta mediates the protective effects of CD40 costimulation against Fas-induced apoptosis. Blood 102, 3270-3279
Jennifer Skeen	Hay, Nissim	Skeen, J. E., Bhaskar, P. T., Chen, C. C., Chen, W. S., Peng, X. D., Nogueira, V., Hahn-Windgassen, A., Kiyokawa, H., and Hay, N. (2006). Akt-deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner. Cancer Cell in press.
		Kandel, E. S., Skeen, J., Majewski, N., Di Cristofano, A., Pandolfi, P. P., Feliciano, C. S., Gartel, A., and Hay, N. (2002). Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage. Mol Cell Biol 22, 7831-7841.
		King, F. W., Skeen, J., Hay, N., and Shtivelman, E. (2004). Inhibition of Chk1 by activated PKB/Akt. Cell Cycle 3, 634-637.
		Peng, X. D., Xu, P. Z., Chen, M. L., Hahn-Windgassen, A., Skeen, J., Jacobs, J., Sundararajan, D., Chen, W. S., Crawford, S. E., Coleman, K. G., and Hay, N. (2003). Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Genes Dev 17, 1352-1365
		Majewski, N., Nogueira, V., Bhaskar, P., Coy, P. E., Skeen, J. E., Gottlob, K., Chandel, N. S., Thompson, C. B., Robey, R. B., and Hay, N. (2004). Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Mol Cell 16, 819-830.
		Hahn-Windgassen, A., Nogueira, V., Chen, C. C., Skeen, J. E., Sonenberg, N., and Hay, N. (2005). Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. J Biol Chem 280, 32081-32089.
Cristiane Lin	Lau, Lester F	Lin, C., Leu, S.-J., Chen, N., Tebeau, C.M., Lin, S.-X., Yeung, C.-Y., and Lau, L.F. (2003) CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family. J. Biol. Chem. 278, 24200-24208. Lin, C.G., Chen, C.C., Leu, S.J., Grzeszkiewicz, T.M., and Lau, L.F. (2005) Integrin-dependent functions of the angiogenic inducer NOV (CCN3): Implication in wound healing. J Biol Chem. 280: 8229-8237.
Quan Hoang	Nakajima, Yasuko	Hoang QV, Bajic D, Yanagisawa M, Nakajima S, and Nakajima Y., 2003, “Effects of orexin (hypocretin) on GIRK channels,” J Neurophysiology; 90:693-702. Bajic D, Hoang QV, Nakajima S, and Nakajima Y, 2004, “Dissociated histaminergic neuron cultures from the tuberomammillary nucleus of rats: culture methods and ghrelin effects,” J Neurosci Methods; 132:177-184. Hoang QV, Zhao P, Nakajima S, and Nakajima Y., 2004, “Orexin (hypocretin) effects on constitutively active inward rectifier K+ channels in cultured nucleus basalis neurons,” J Neurophysiology; 92:3183-91.
Jason Derry	Tyner, Angela	Derry, J., Richard S. , Valderrama Carvaja, H., Ye X., Cochrane A. W., Vasioukhin V., Chen T., and A. L. Tyner. 2000. Sik/BRK phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability. Mol. Cell. Biol. 20, 6114-6126.
		Kwek S. S. S., Derry, J., Tyner A.L., Shen Z., and A.V. Gudkov. 2001. Functional Analysis and intracellular localization of p53 modified by SUMO-1. Oncogene 20, 2587-99.
		Derry J.J., Prins G.S., Ray V., and A. L. Tyner. 2003. Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells. Oncogene 22, 4212-4220.
		Haegebarth A, Heap D, Bie W, Derry JJ, Richard S, and A. L. Tyner. 2004. The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2. J Biol Chem. 279, 54398-54404.
Masakatsu Nanamori	Ye, Richard	Nanamori, M., He, R., Sang, H. and Ye, R.D. (2004) Normal cell surface expression and selective loss of functions resulting from Phe110 to Ser and Cys126 to Trp substitutions in the formyl peptide receptor. Immunol. Invest. 33:193-212.
		Nanamori, M., Cheng, X., Mei, J., Sang, H., Xuan, Y., Zou, C., Wang, M.W., and Ye, R.D. (2004) A novel nonpeptide ligand for formyl peptide receptor-like 1. Mol. Pharmacol. 66:1213-1222.
		Yan, P., Nanamori, M., Sun, M., Zhou, C., Cheng, N., Li, N., Zheng, W., Xiao, L., Xie, X., Ye, R.D. and Wang, M.W. (2006) The immunosuppressant cyclosporin A antagonizes human formyl peptide receptor through inhibition of cognate ligand binding. J. Immunol. In press.
Christine Doyle	Ackerman, Steven	Kwatia MA, *Doyle CB,** Cho W, Enhorning G and Ackerman SJ. The combined activities of secretory phospholipases and eosinophil lysophospholipases induce pulmonary surfactant dysfunction by phospholipid hydrolysis. J. Allergy Clin. Immunol., 2006: in press.Co-first author. Liu L, Doyle CB, Kwatia MA and Ackerman SJ. Identification of Ligands for Charcot-Leyden Crystal Protein (Galectin-10) in Human Eosinophils: Selective Interactions with Granule Cationic Ribonucleases. J. Biol. Chem. 2006; submitted.*Co-first author.Ackerman SJ, Kwatia MA, Doyle CB, and Enhorning G. Hydrolysis of surfactant phospholipids catalyzed by phospholipase A2 and eosinophil lysophospholipases causes surfactant dysfunction: A mechanism for small airway closure in asthma. Chest 2003;123:355S.
Mark Pilkington	Colamonici, Oscar	1) Sandoval, R., Xue, J., Tian, X., Barrett, K., Pilkinton, M., Ucker, D. S. Raychaudhuri, P., Kineman, R. D., Luque, R. M., Baida, G., Zou, X., Valli, V. E., Kiyokawa, H., and Colamonici, O. R. Rescue of the CDK4–/– phenotype by a mutant allele of BARA/LIN-9. Exp. Cell Res, 312, 2465-75, 2006 2) Sandoval, R., Xue, J., Pilkinton, M., Salvi, D., Kiyokawa, H., and Colamonici, O. R. Different requirements for the cytostatic and apoptotic effects of type I interferons. Induction of apoptosis requires ARF but not p53 in osteosarcoma cell lines. J Biol Chem, , 279: 32275-32280, 2004. 3) Pilkinton, M., Sandoval, R., Song, J., Ness, S.A., and Colamonici, O. R. Mip/LIN-9 regulates the expression of B-MYB, and the induction of cyclin A, cyclin B and CDK1. submitted. 2006
Nathan Stitziel	Liang, JieWestbrook, Carol	Stitziel NO, Mar BG, Liang J, Westbrook CA, 2005, “Membrane-Associated and Secreted Genes in Breast Cancer,” Cancer Research, 64(23): 8682-7. Stitziel NO, Binkowski TA, Tseng YY, Kasif S, Liang J., 2004, “topoSNP: A Topographic Database of Non-synonymous Single Nucleotide Polymorphisms with and without Known Disease Association,” Nucleic Acids Research, 32: D520-22. Stitziel NO, Tseng YY, Pervouchine D, Goddeau D, Kasif S, Liang J., 2003, “Structural Location of Disease-Associated Single Nucleotide Polymorphisms,” J Mol Biol 327; 1021-1030.

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