©2012 UIC Section of Cardiology, University of Illinois at Chicago
Samuel C. Dudley, M.D., Ph.D.
Welcome to Dr. Samuel C. Dudley's cardiovascular research laboratory.
The laboratory spans from the basic science to investigator-
The laboratory has pioneered many advances in the understanding of the cardiac Na+
channel. He has contributed to understanding the structure, regulation, and pathophysiology
of the channel. The laboratory was the first 1) to demonstrate the spatial organization
of the channel domains, 2) to clone and describe the function of the full-
In addition, the laboratory has developed a new line of research centered on the role of oxidative stress in atrial fibrillation (AF). He has been able to show that AF results in increased oxidative stress, most predominantly in the left atrium. This is coupled with endocardial remodeling contributing to the propensity for thrombus formation in this chamber and may represent part of the reason for the success of ablation strategies focused on this chamber. This research has led to insights into oxidative stress and diastolic HF, a potential new blood test for AF risk, and a human clinical trial to see statins will reduce atrial fibrillation (AF) recurrences.
In an additional line of work, the laboratory has been developing tissue engineered approaches for cardiac cell replacement. The laboratory was one of the earliest in the development of embryonic stem cells for this use and recently describe a new approach to increase cell engraftment.
RECENT LABORATORY NEWS
Dr. Dudley's laboratory was awarded recently funding by the National Institutes of Health for the application titled "Oxidative Stress and Left Ventricular Diastolic Function" as part of a Program Project Grant.
Dr. Dudley was recently inducted in the American Society of Clinical Investigation.
GRANTS AND PUBLICATIONS
|Cardiac and Peripheral Interventions|
|Cardiovascular Magnetic Resonance (CMR) Program|
|Echocardiography and Stress Testing|
|Pre and Post Doc|