Theodore Mazzone , MD

Professor of Medicine
Professor of Pharmacology
Chief, Section of Endocrinology, Diabetes and Metabolism
Department of Medicine

University of Illinois at Chicago

Business office: 312/996-7989
Nutrition & Wellness Center - Appointment Desk: 312/413-3631
Fax: 312-413-0437

Board certification: Internal Medicine, Endocrinology
Medical School: Northwestern University
Residency: UCLA
Fellowship: University of Washington, Medical Center

Clinical Interest:
Insulin Resistance
Lipid Disorders
Multiple Risk Factor Diabetes

Research interests:
Mechanism and prevention of artherosclerosis
Prevention of Macrovascular complications of diabetes

Adipose Tissue Lipid Metabolism in Obesity

Selected Recent publications:

Huang, Z.H., Reardon, C.A., and Mazzone, T.  Endogenous apoE expression modulates adipocyte triglyceride content and turnover.  Diabetes, 55:3394-402, 2006.

2. Goldberg, R., Gayton, J., Mazzone, T., Weinstock, R., Polis, A., Edwards, P., Tomassini, J., and Tershakovec, A.  Ezetimibe/simvastatin (vytorin) versus atorvastatin in Type 2 diabetes patients with hypercholesterolemia: The VYTAL Study.  Mayo Clin. Proc. 81:1579-88, 2006.

3. Mazzone, T., Meyer, P., Feinstein, S.B., Davidson, M.H., Kondos G.T., D’Agostino, R.B., Perez, A., Provost, J-C., and Haffner, S.M.  Effect of pioglitazone compared to glimepiride on carotid intima-media thickness in Type 2 diabetes.  A randomized trial.  JAMA, 296:2572-81, 2006.

4. Zhao, T., and Mazzone, T.  Turning "waste" into gold: identification of novel stem cells from human umbilical cord blood.  Discov. Med. 6:87-89, 2006.

5. Luque, R.M., Huang, Z.H., Shah, B., Mazzone, T., and Kineman, R.D.  Effects of leptin replacement on hypothalamic-pituitary growth hormone (GH) -axis function and circulating ghrelin levels in ob/ob mice.  Am. J. Physiol. Endocrinol. Metab., 292:E891-E899, 2007.

6. Zhao, Y., Huang, Z.H., Qi, M., Lazzarini, P., and Mazzone, T.  Immune regulation of T lymphocyte by a newly characterized human umbilical cord blood stem cell.  Immunology Letters, 108:78-87, 2007

7. Lucic, D., Huang, Z.H., Gu, D., Altenburg, M.K., Maeda, N., and Mazzone, T.  Regulation of macrophage apoE secretion and sterol efflux by the LDL receptor.  J. Lipid Res. 48:366-372, 2007.

8. Cotler, S.J., Guzman, G., Layden-Almer, J., Mazzone, T., Layden, T.J., and Zhou, X.J.  Measurement of liver fat content using selective saturation at 3.0 T.  J. Magn. Reson. Imaging, 25:743-748, 2007.

9. Mazzone, T., Meyer, P., Kondos, G.T., Davidson, M.H., Feinstein, S.B, D’Agostino, R.B., Perez, A., and Haffner, S.M.  Relationship of traditional and non-traditional cardiovascular risk factors to coronary artery calcium in Type 2 diabetes.  Diabetes, 56:849-855, 2007.

10. Fantuzzi, G., and Mazzone, T.  Adipose tissue and atherosclerosis – exploring the connection.  Arterioscler. Thromb. Vasc. Biol., 27:996-1003, 2007.

11. Huang, Z.H., Luque, R.M., Kineman, R.D., and Mazzone, T.  Nutritional regulation of adipose tissue apolipoprotein E expression.  Am. J. Physiol. Endocrinol. Metab., 293:E203-E209, 2007.

12. Mazzone, T.  HDL cholesterol and atherosclerosis.  Lancet, 370:107-108, 2007.

13. Mazzone, T.  Prevention of macrovascular disease in patients with diabetes mellitus: opportunities for intervention.  Am. J. Med., 120 (Suppl): S26-S32, 2007.

14. Lucic, D., Huang, Z.H., Gu, D., Subbaiah, P.V., and Mazzone, T.  Cellular sphingolipids regulate macrophage apolipoprotein E secretion.  Biochemistry, 46:11196-11204, 2007. 

15. Rao, P., Huang, Z.H., and Mazzone, T.  Angiotensin II regulates adipocyte apolipoprotein E expression.  J. Clin. Endocrinol. Metab., 92:4366-4372, 2007.

16. Mazzone, T.  Adipose tissue and the vessel wall.  Curr. Drug Targets, 8:1190-1195, 2007.

17. Guyton, J.R., Goldberg, R.B., Mazzone, T., Weinstock, R.S., Polis, A., Rosenberg, E., and Tershakovec, A.M.  Lipoprotein and apolipoprotein ratios in the VYTAL trial of ezetimibe/simvastatin compared with atorvastatin in Type 2 diabetes.  J. Clin. Lipidol., 2:19-24, 2008. 

18. Weinstock, R.S., Goldberg, R.B., Guyton, J.R., Mazzone, T., Polis, A., Tomassini, J.E., Lin, J., Shah, A., and Tershakovec, A.M.  Effect of ezetimibe/simvastatin vs atorvastatin on lowering levels of LDL-C and non-HDL-C, apoB, and hs-CRP in patients with type 2 diabetes.  J. Clin. Lipidol., 2:25-35, 2008.

19. Deedwania, P., Kosiborod, M., Barrett, E., Ceriello, A., Isley, W., Mazzone, T., and Raskin, P.  Hyperglycemia and acute coronary syndrome: a scientific statement from the American Heart Association Diabetes Committee of the Council on Nutrition, Physical Activity, and Metabolism.  Circulation, 117:1610-1619, 2008.

20. Davidson, M., Meyer, P.M., Haffner, S., Feinstein, S., D’Agostino, R., Kondos, G.T., Perez, A., Chen, Z., and Mazzone, T.  Increased high-density lipoprotein cholesterol predicts the pioglitazone-mediated reduction of carotid intima-media thickness progression in patients with Type 2 diabetes mellitus.  Circulation, 117:2123-2130, 2008.

21. Mazzone, T., Chait, A., and Plutzky, J.  Addressing cardiovascular disease risk in diabetes: insights from mechanistic studies. Lancet, 371:1800-1809, 2008.  

22. Yue, L., Christman, J., and Mazzone, T.  TNF{α}-mediated suppression of adipocyte apolipoprotein E gene transcription: Primary role for the NF{kappa}B pathway and NF{kappa}B p50.  Endocrinology, 149:4051-4058, 2008.

23. Sam, S., Davidson, M.H., D’Agostino, R.B., Feinstein, S, Kondos, G.T., Perez, A., and Mazzone, T.  Relationship of Abdominal Visceral and Subcutaneous Adipose Tissue to Lipoprotein Particle Number and Size in Type 2 Diabetes.  Diabetes, 57:2022-2027, 2008.

24. Espiritu, D.J., and Mazzone, T.  Oxidative stress regulates adipocyte apolipoprotein E and suppresses its expression in obesity.  Diabetes, 57:2992-2988, 2008.

25. Sam, S., Haffner, S., Davidson, M.H., D’Agostino, R.B., Feinstein, S, Kondos, G.T., Perez, A., and Mazzone, T.  Relation of abdominal fat depots to systemic markers of inflammation in Type 2 diabetes.  Diabetes Care, 32:932-937, 2009.

26. Huang, Z.H., Gu, D., and Mazzone, T.  Role of adipocyte-derived apoE for modulating adipocyte size, lipid metabolism, and gene expression in vivoAm. J. Physiol. Endocrinol. Metab., 296:E1110-E1119, 2009.

27. Yue, L., and Mazzone, T.  PPARgamma stimulation of adipocyte apoE gene transcription mediated by the LXR pathway.  J. Biol. Chem, 284:10453-10461, 2009.

28. Huang, Z.H., Minshall, R.D., and Mazzone, T.  Mechanism for endogenously expressed apoE modulation of adipocyte VLDL metabolism: role in endocytic and lipase-mediated metabolic pathways.  J. Biol. Chem., 284:31512-31522, 2009.

29. Espiritu, D.J., Huang, Z.H., Zhao, Y., and Mazzone, T.  Hyperglycemia and advanced glycosylation end products suppress adipocyte apoE expression: implications for adipocyte triglyceride metabolism.  Am. J. Physiol. Endocrinol. Metab., 299:E615-E623, 2010.

30. Mazzone, T.  Intensive glucose lowering and cardiovascular disease prevention in diabetes; reconciling the recent clinical trials data.  Circulation, 122:2201-2211, 2010.

[Endocrine Society]

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