Lawrence A. Frohman, M.D.

Professor Emeritus of Medicine

Business office: 312-996-7525
Appointments: 312/996-6062
Fax: 312-355-3590
E mail: frohman@uic.edu

Board Certification: Internal Medicine
Medical School: University of Michigan
Residency: Yale New Haven Medical Center
Fellowship: Duke University Medical Center

Clinical Interests: Neuroendocrinology and Pituitary Disease, Ectopic Hormone Secretion

Research Interests: Regulation of Growth Hormone Secretion, Hypothalamic Hormones, Pituitary Tumorigenesis

Staying up to date (continuing medical education):
Endocrine Society Annual Meeting
American Society for clinical Investigation Annual Meeting
International Pituitary Congress
International Congress of Neuroendocrinology
Central Society for Clincal Research Annual Meeting

Invited lectures:
1. Diagnosis and treatment of growth hormone deficiency in adults
2. Pituitary tumors and pregnancy
3. Establishing the diagnosis and assessment of therapy in acromegaly
4. Familial pituitary tumors
7. Growth hormone releasing hormone receptor mutations
8. Prolactinoma diagnosis and treatment
9. Molecular basis for pituitary disease
10. Cushing's Disease: diagnosis and therapy

Recent Publications:
Gadelha MR, Une KN, Rhode K, Vaisman M, Kineman RD, Frohman LA: Isolated familial somatotropinomas: establishment of linkage to chromosome 11q13.1-11q13.3 and evidence for a potential second locus at chromosome 2p16-12. J Clin Endocrinol Metab 85:707-714, 2000

Frohman LA, Felig PA (eds): Endocrinology and Metabolism, 4th Edition, McGraw-Hill, New York, 2001

Frohman LA : Pituitary tumors in pregnancy. The Endocrinologist 11:399-406, 2001

Kineman R, Teixeira LT, Amargo GV, Coshigano KT, Kopchick JJ, Frohman LA : The effect of growth hormone (GH)-releasing hormone hormone (GHRH) on somatotrope hyperplasia and tumor formation in the presence and absence of GH signaling. Endocrinology 142: 3764-3773, 2001

Frohman LA, Kineman RD : Growth hormone-releasing hormone and pituitary development, hyperplasia, and tumorigenesis. Trends Endocrinol Metab 13:299-303, 2002

Frohman LA: Controversy on treatment of growth hormone-deficient adults: A commentary (editorial). Ann Intern Med 137:202-204, 2002

Frohman LA : The role of target gland failure and hypothalamic hormones in pituitary tumor formation. In: Central and Peripheral Mechanisms in Pituitary Disease, (Kleinberg D, Clemmons D, eds), Bioscientifica, Bristol, 2003:135-148.

Soares BS, Frohman LA: Isolated Familial Somatotropinoma. Pituitary 7:95-101, 2004

Vidal A, Zacharoulis S, Guo W, Shaller D, Giancotti F, de la Hoz C, Kato D, Knowles J, Yeh N, Frohman LA, Raffii S, Lyden D, Koff A: p130 and p27 co-operate to control mobilization of angiogenic progenitors from the bone marrow. Proc Nat Acad Sci 102:6890-6895, 2005

Soares BS, Eguchi K, Frohman LA: Tumor deletion mapping on chromosome 11q13 in 8 families with Isolated Familial Somatotropinoma and in 15 sporadic somatotropinomas. J Clin Endocrinol Metab 90 6580-6587, 2005

Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne J-P, Frohman, LA Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab 91:799-805, 2006

Ionescu M, Frohman LA: Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GHRH analog. J Clin Endocrinol Metab 91:4792-4797, 2006

Frohman, L.A.: Management of Pituitary Incidentalomas. In: Pituitary Tumors: Diagnosis and Management, Biller BMK, Swearingen B eds) Humana Press, Totowa, NJ, 2007 (in press) Naing S, Frohman LA: The empty sella. Ped Endocrinol Rev 2007 (in press)

Naing S, Frohman LA: The empty sella. Ped Endocrinol Rev 2007 (in press)

Links
[Endocrine Society][Pituitary Society]