Lawrence A. Frohman, M.D.

Professor Emeritus of Medicine

Business office: 312-996-7525
Appointments: 312/996-6062
Fax: 312-355-3590
E mail:

Board Certification: Internal Medicine
Medical School: University of Michigan
Residency: Yale New Haven Medical Center
Fellowship: Duke University Medical Center

Clinical Interests: Neuroendocrinology and Pituitary Disease, Ectopic Hormone Secretion

Research Interests: Regulation of Growth Hormone Secretion, Hypothalamic Hormones, Pituitary Tumorigenesis

Staying up to date (continuing medical education):
Endocrine Society Annual Meeting
American Society for clinical Investigation Annual Meeting
International Pituitary Congress
International Congress of Neuroendocrinology
Central Society for Clincal Research Annual Meeting

Invited lectures:
1. Diagnosis and treatment of growth hormone deficiency in adults
2. Pituitary tumors and pregnancy
3. Establishing the diagnosis and assessment of therapy in acromegaly
4. Familial pituitary tumors
7. Growth hormone releasing hormone receptor mutations
8. Prolactinoma diagnosis and treatment
9. Molecular basis for pituitary disease
10. Cushing's Disease: diagnosis and therapy

Recent Publications:

Frohman LA, Felig PA (eds): Endocrinology and Metabolism, 4th Edition, McGraw-Hill, New York, 2001

Frohman LA : Pituitary tumors in pregnancy. The Endocrinologist 11:399-406, 2001

Kineman R, Teixeira LT, Amargo GV, Coshigano KT, Kopchick JJ, Frohman LA : The effect of growth hormone (GH)-releasing hormone hormone (GHRH) on somatotrope hyperplasia and tumor formation in the presence and absence of GH signaling. Endocrinology 142: 3764-3773, 2001

Frohman LA: Controversy on treatment of growth hormone-deficient adults: A commentary (editorial). Ann Intern Med 137:202-204, 2002

Frohman LA : The role of target gland failure and hypothalamic hormones in pituitary tumor formation. In: Central and Peripheral Mechanisms in Pituitary Disease, (Kleinberg D, Clemmons D, eds), Bioscientifica, Bristol, 2003:135-148.

Soares BS, Frohman LA: Isolated Familial Somatotropinoma. Pituitary 7:95-101, 2004

Vidal A, Zacharoulis S, Guo W, Shaller D, Giancotti F, de la Hoz C, Kato D, Knowles J, Yeh N, Frohman LA, Raffii S, Lyden D, Koff A: p130 and p27 co-operate to control mobilization of angiogenic progenitors from the bone marrow. Proc Nat Acad Sci 102:6890-6895, 2005

Soares BS, Eguchi K, Frohman LA: Tumor deletion mapping on chromosome 11q13 in 8 families with Isolated Familial Somatotropinoma and in 15 sporadic somatotropinomas. J Clin Endocrinol Metab 90 6580-6587, 2005

Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne J-P, Frohman, LA Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab 91:799-805, 2006

Ionescu M, Frohman LA: Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GHRH analog. J Clin Endocrinol Metab 91:4792-4797, 2006

Frohman LA, Bonert V: Pituitary tumor enlargement in two patients with acromegaly during pegvisomant therapy. Pituitary 10:283-289, 2007

Naing S, Frohman LA: The empty sella. Ped Endocrinol Rev 4:335-342, 2007

Sam S, Frohman LA: Normal physiology of hypothalamic pituitary regulation. Endocr Metab Clin North Am 37:1-22, 2008

Leontiou CA, Gueorguiev M, van der Spuy J, Quinton R, Lolli F, Hassan S, Chahal HS, Igreja SC, Jordan S, Rowe J, Stolbrink M, Christian HC, Wray J, Bishop-Bailey D, Berney DM, Wass JAH, Popovic V, Ribeiro-Oliveira A Jr, Gadelha MR, Monson JP, Akker SA, Davis JRE, Clayton RN, Yoshimoto K, Iwata T, Matsuno A, Eguchi K, Musat M, Flanagan D, Peters G, Bolger GB, Chapple JP, Frohman LA, Grossman AB, Korbonits M: The Role of the AIP Gene in Familial and Sporadic Pituitary Adenomas. J Clin Endocrinol Metab 93:2390-2401, 2008

Frohman, L.A.: Management of Pituitary Incidentalomas. In: Diagnosis and Management of Pituitary Disorders, Swearingen B, Biller BMK  eds) Humana Press, Totowa, NJ, 2008, pp 399-410

Frohman LA: Hamartomas and Gangliocytomas. In: Clinical Endocrine Oncology, 2nd Ed (Hay ID, Wass JAH eds), Blackwell Publishing, Oxford, 2008, pp 293-297

[Endocrine Society][Pituitary Society]

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