Terry
G. Unterman, M.D.
Professor
of Medicine, Physiology and Biophysics
Phone: 312-569-7427
Fax: 312-569-8114
E-mail: Unterman@uic.edu
Board Certification:
Internal Medicine, Endocrinology
Medical School: Duke University Medical School
Residency and Chief Residency: Rush-Presbyterian St. Luke's Medical Center,
Chicago
Fellowship: Endocrinology, Northwestern University
Clinical Interests: Growth hormone and insulin-like
growth factors, Diabetes Mellitus (pathogenesis and management), Endocrinology
of aging
Staying up to date (continuing medical education):
Endocrine Society Meeting, June 2007
American Diabetes Association, June 2008
Invited lectures:
Growth Hormone in Grown-ups
Medical Grand Rounds, UIC Department of Medicine (12/12/06)
FoxO Transcription Factors: Mediators and modulators of insulin action
Department of Molecular & Inegrative Physiology, University of Michigan Medical Center, Ann Arbor, MI (2/28/07)
Chair, Session on "Emerging Aspects of Insulin Action and Glucose Homeostasis" Annual Meeting of the Endocrine Society, Toronto, Ontario (6/2/07)
“FoxO Transcription Factors: Mediators and Modulators of Insulin Action,” Department of Human Nutrition and Metabolism, Hebrew University Medical School, Ein Karem, Jerusalem, Israel (7/6/07)
“Regulation of Hepatic Gene Expression and Metabolism by FoxO Transcription Factors,” University of Tennessee Medical School, Memphis, TN (04/21/08)
Research Interests: Regulation of gene expression
and metabolism by insulin and growth factors; FoxO transcription factors; Regulation
of metabolism in obesity and diabetes; Endocrinology of aging
Recent
Publications:
2. Xinmin, Z., Odom, D.T., Koo, S.-H., Guzman, E., Simone, C., Conkright, M.D., Canettieri, G., Best, J., Jenner, R., Herbolsheimer, E., Jacobsen, E., Kadam, S., Emerson, B., Hogenesch, J.B., Unterman, T., Young, R.A., and Montminy, M. Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc Natl Acad Sci USA 102:4459-4464, 2005.
3. Zhang, W., Patil, S., Klotsas, A., Chauhan, B., Le, J., Franks, R., Guo, G., Powell, D.R., Heidenreich, K., Sajan, M.P., Farese, R.V., Beer-Stoltz, D., Tso, P., Koo, S.-H., Montminty, M. and Unterman, T.G. FoxO1 Regulates Multiple Metabolic Pathways in the Liver: Effects on Gluconeogenic, Glycolytic and Lipogenic Gene Expression. J Biol Chem 281(15):10105-17, 2006.
4. Buzzio, O.L., Lu, Z., Miller, C.D., Unterman, T.G. and Kim, J.J. FOXO1A Differentially regulates genes of decidualization. Endocrinology, 147(8):3870-6, 2006.
5. Peterfi, Z., Obal, F. Jr., Taishi, P., Gardi, J., Kacsoh, B., Unterman, T., and Krueger, J.M. Sleep in spontaneous dwarf rats. Brain Res 1108:133-46, 2006.
6. Zhang, Y., Ma, K., Chowdhury, P.S.F., Gaillard, S., Wang, F., McDonnell, D.P., Unterman, T.G., Elam, M.B., and Park, E.A. Estrogen Related Receptors Stimulate Pyruvate Dehydrogenase Kinase Isoform 4 (PDK4) Gene Expression, J Biol Chem 281(52):39897-906, 2006.
7. Zhang X, Mehta RG, Coshigano KT, Kopchick JJ, Green JE, Hearat S, Christov KT, Unterman TG, and Swanson SM. Inhibition of estrogen independent mammary carcinogenesis by disruption of growth hormone signaling. Carcinogenesis, 28:143-50, 2007.
8. Allen, D.L. and Unterman, T.G. Regulation of myostatin expression and myoblast differentiation by FoxO and SMAD transcription factors. Amer J Physiol 292(1):C188-99, 2007.
9. Yoshida1, K., Murao, K., Imachi1, H., Wenming, C., Yu, X., Li, J., Ahmed, R.A.M., Ke, C., Wong, N.M.C., Unterman, T.G., Magnuson, M.A., and Ishida, T. Pancreatic Glucokinase is activated by Insulin-like Growth Factor I. In Press, Endocrinology, 2007.
10. Ono, M., Chia, D.J., Zhang, W., Unterman, T.G., Flores-Morales, A., and Rotwein, P. Stat5b-mediated Inhibition of IGF Binding Protein-1 Gene Transcription: A Mechanism for Repression of Gene Expression by Growth Hormone. Mol Endocrinol. 21(6):1443-57, 2007.
11. Halperin, J., Devi, S.Y., Elizur, S., Stocco, C., Shelu, A., Rebource, D., Unterman, T.G., Leslie, N.D, Binart, N., and Gibori, G. Prolactin Signaling Through the Short Form of Its Receptor Represses FOXO3a and its Target Gene GALT Causing a Severe Ovarian Defect. Mol Endocrinol 2:513-22, 2008.
12. Wang, Z., Luque, R.M., Kineman, R.D., Ray, V.H., Christov, K.T., Lantvit, D.D., Shirai, T., Hedayat, S., Unterman, T.G., Bosland, M.C., Prins, G.S., and Swanson, S.M. Disruption of Growth Hormone Signaling Retards Prostate Carcinogenesis in the Probasin/TAg Rat. Endocrinology 149(3):1366-76, 2008.
13. Kamei, Y., Miura, S., Suganami, T., Akaike, T., Kanai, S., Sugita, S., Katsumata, A, Aburatani H., Unterman T.G., Ezaki, O., and Ogawa, Y. Regulation of SREBP1c gene expression in skeletal muscle: role of RXR/LXR and FOXO1. Endocrinology 149:2293-305, 2008.
