Research activities of the FGICU
Along with the clinical services, the FGICU group maintains a very active research program that studies different aspects of colorectal cancer.
A. Hereditary Gastrointestinal Cancer
1. Study of colorectal cancers without polyposis and inherited in an autosomal dominant fashion but not Lynch type. This is likely the largest group of familial cancers and the causing hereditary defects have not yet been found. We are taking different strategic approaches in order to unveil the underlying inherited defects. The studies are performed in collaboration with different institutions such as Baylor College, Harvard, Creighton University, Universidad Complutense and the Spanish collaborative group on the study of colorectal cancer (Epicolon consortium).
2. Study of the unique features of African Americans and other minorities with hereditary non-polyposis colorectal cancer. Most of the information on hereditary colorectal cancer syndromes has been derived from studies with an overwhelming majority of Caucasian patients. Many important aspects have not been well studied in minority populations. We are specially focusing in African Americans and other minority groups. These studies are being performed in collaboration with the University of Chicago, Stroeger Cook County hospital, Northwestern University and Jesse Brown VA Medical Center.
B. Effects of Nutrients in Colorectal Cancer
1. Study of the chemo-preventive effect of n-3 fatty acids and fiber components on colorectal cancer. Our studies focus on the anti-cancer activity that these components have by regulating death and reproduction of malignant colon cancer cells.