|
RESEARCH FACULTY - RAMASWAMY'S LAB
Molecular Physiology of Diarrhea
University of Illinois at Chicago
Jesse Brown VA Medical Center
Research Efforts:
Na+/H+ Exchangers: Studies in the human small intestine and colon have shown very efficient absorption of sodium chloride, mostly occurring via an electroneutral mechanism involving the dual ion exchanges of Na+/H+ and Cl-/HCO3-. Recent studies have identified a family of NHE isoforms including NHE-1 to 4 in the rat and rabbit. No information is currently available on the structure-function relationships and regulation of the human NHE-2 and NHE-3 isoforms, and , therefore, our laboratory focuses its efforts on these two putative apical isoforms implicated in Na+ absorption. Our laboratory has recently cloned the human NHE-2 isoform, and current ongoing studies include investigations of the structure-function relationships and regulatory mechanisms for NHE-2 and NHE-3 isoforms to gain insights into their individual role in apical sodium absorption.
Anion Exchangers: Studies in collaboration with Dr. Dudeja focus on identifying the anion exchanger isoform (s) involved in chloride and anion transport in the human small intestine and colon. Ongoing studies also include cloning the monocarboxylate transporters (MCT1 and MCT2) from the human intestine to investigate their possible role in short-chain fatty acid absorption by the human colon.
Lab Personnel:
K. Ramaswamy, PhD
Ruhul Amin, MD, PhD
Eleanor Murray, BA
Hani Najafi-Shoushtari, PhD
Contact Information:
Clinical Sciences Building
840 South Wood Street, Room 728A
Phone: 312-996-0899
Fax: 312-996-5103
BACK TO DDN HOME
|
