ADDRESS
Section of Digestive Diseases and Nutrition
University of Illinois at Chicago
840 S. Wood Street (M/C 716)
Chicago, IL 60612
Telephone: 312-996-6651
Fax: 312-996-5103
E-mail
EDUCATION
Doctorate of Philosophy
Specialization: Hepatoprotection and Biochemistry
R.M.L. University, Faizabad, U.P, India
Master of Science (Biochemistry)
Lucknow University, Lucknow, India
Bachelor of Science (Chemistry, Botany)
Lucknow University, Lucknow, India
PUBLICATIONS
• Saksena S, Gill RK, Tyagi S, Alrefai WA, Ramaswamy K and Dudeja PK. Involvement of c-Src and PKC d in the inhibition of Cl - / OH - exchange activity in Caco2 cells by Serotonin. J. Biol. Chem. Mar; 280(12): 11859-68, Epub 2005, Jan 6.
• Gill RK, Saksena S, Tyagi S, Alrefai WA, Ramaswamy K and Dudeja PK. Serotonin regulates Na + /H + exchange in Caco2 Cells by causing tyrosine phosphorylation of PLC g 1 and activation of PKC a . Gastroenterology , Apr; 128(4): 962-74, 2005.
• Gill RK, Saksena S, Alrefai WA, Sarwar Z, Goldstein JL, Carroll RE, Ramaswamy K and Dudeja PK. Expression and Membrane localization of MCT isoforms along the length of the human intestine. Am. J. Physiol. (Cell Physiol) May 18 , Epub ahead of print] 2005.
• Saksena S, Gill RK, Tyagi S, Alrefai WA, Ramaswamy K and Dudeja PK. Involvement of PI3 kinase and its association with p59Fyn in H 2 O 2 -induced inhibition of Cl - / OH - exchange in Caco-2 cells. J. Biol. Chem (Submitted) 2005.
• Alrefai WA, Sarwar Z, Tyagi S, Saksena S, Dudeja PK and Gill RK. Cholesterol modulates human intestinal sodium dependent bile acid transporter Am. J. Physiol. May; 288(5): G978-85, Epub 2004, Dec 16.
• Alrefai WA , Tyagi S, Gill RK , Saksena S, Hadjiagapou C, Mansour F, Ramaswamy K and Dudeja PK. Regulation of butyrate uptake in Caco-2 cells by phorbol 12-myristate 13 acetate, PMA. Am. J. Physiol. Feb; 286(2): G197-203. 2004.
• Alrefai WA , Saksena S, Tyagi S, Sarwar Z, Gill RK and Dudeja PK. Taurodeoxycholic bile acid inhibits chloride uptake in Caco-2 cells. Am. J. Physiol. (Submitted) 2005.
• Saksena S, Gill RK, Tyagi S, Syed IA, Alrefai WA, Ramaswamy K and Dudeja PK. Modulation of Cl - /OH - Exchange Process in Caco2 Cells by Nitric Oxide. Am. J. Physiol. (GI and Liver Physiol) 283(3): G626-G633, 2002.
• Saksena S, Gill RK, Tyagi S, Syed IA, Alrefai WA, Ramaswamy K and Dudeja PK. A Role for PKC- e in the Inhibition of Apical Cl - /OH - Exchange Activity in Caco2 Cells by Phorbol Ester PMA. Am. J. Physiol. (Cell Physiol) 283(5): C1492-C1500, 2002.
• Saksena S, Sammer M , Tyagi S, Elsharydah A, Gill RK, Ramaswamy K and Dudeja PK. Mechanisms of calcium transport across the human colonic basolateral membrane vesicles. Digestive Diseases & Sciences. 47: 2306-15, 2002.
• Gill RK, Saksena S, Syed IA, Tyagi S, Alrefai WA, Ramaswamy K and Dudeja PK. Regulation of NHE-3 by Nitric Oxide in Caco2 Cells Am. J. Physiol. (GI and Liver Physiol) 283(3): G47-G756, 2002.
• Alrefai WA, Tyagi S, Mansour F, Saksena S, Syed IA, Ramaswamy K and Dudeja PK. Sulfate and Chloride Transport in Caco2 Cells: Differential Regulation by Thyroxine and the Possible Role of DRA Gene. Am. J. Physiol. Gastrointest. Liver Physiol. 280: G603-G613, 2001.
• Mittal N, Gupta N, Saksena S, Goyal N, Roy U and Rastogi AK. Protective effect of Picroliv from Picrorhiza kurroa against L.donovani infection in Mesocricetus auratus. Life Sci; 63:1823, 1998.
• N. Mittal, N. Gupta, S. Saksena, N. Goyal, U. Roy and A.K. Rastogi. Effect of Pentamidine isethiocyanate on hepatic markers in golden hamsters during Leishmania donovani infection. Biomedical Research. 18: 205-210, 1997.
• Rastogi R, Saksena S, Tripathi SC, Hussaini FA, Shoeb A, Dhawan BN and Ram VJ. Hepatoprotective activity of 6-(4-bromophenyl)-4-methylthio-2-oxo-2H-pyran-3-carbonitryl against hepatotoxicity induced by galactosamine and thioacetamide in rats. Med. Sci. Res; 26: 729-731, 1998.
• Saksena S, Rastogi R, Garg NK and Dhawan BN. Protective effect of Picroliv on site-specific inhibition of protein biosynthesis in rat liver. Med. Sci. Res ; 25: 547-549, 1997.
• Rastogi R, Saksena S, Garg NK and Dhawan BN. Effect of Picroliv on rifampicin induced biochemical changes in rat liver and serum. Phytotherapy Res; 10: 610-612, 1996.
• Rastogi R, Saksena S, Garg NK, Kapoor NK, Agarwal DP and Dhawan BN. Picroliv protects against alcohol-induced chronic hepatotoxicity in rats. Planta Medica; 62: 283-285, 1996.
• Rastogi R, Saksena S, Garg NK and Dhawan BN. Effect of Picroliv on anti-oxidant system in liver after partial hepatectomy. Phytotherapy Res; 9: 364-367, 1995.
• Saksena S, Rastogi R, Garg NK and Dhawan BN. Rifampicin-induced hepatotoxicity in rats: Protective effect of Picroliv. Drug Dev. Res; 33: 46-50, 1994.
• Saksena S, Rastogi R, Garg NK and Dhawan BN. Effect of Picroliv on regeneration of liver after partial hepatectomy in rats. Phytotherapy Res; 9: 518-521, 1995.
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