V.K. Viswanathan, PhD
Research Assistant Professor
ADDRESS
Section of Digestive Diseases and Nutrition
University of Illinois at Chicago
840 S. Wood Street, Rm 741 (M/C 716)
Chicago, Illinois 60612
Telephone: 312-355-4945
Fax: 312-996-5103
E-mail: vish@uic.edu
RESEARCH INTERESTS:
My research explores the interaction of pathogenic bacteria with the cells of the human host, and seeks to understand the mechanisms by which bacteria exploit this interaction to favor their survival in the body. Specifically, I am interested in the signaling pathways activated in intestinal cells in response to infection with various bacteria including enteropathogenic E. coli, enterohemorrhagic E. coli, Yersinia enterocolitica and Yersinia pseudotuberculosis. Dissecting the processess involved in infection will eventually contribute to a global picture of the specific diseases caused by these organisms, and could provide insights into possible therapeutic approaches.
EDUCATION & TRAINING
PhD in Biological Sciences - University of Illinois at Chicago, USA
MS in Life Sciences - Jawaharlal Nehru University, New Delhi, India
BS in Biology - St. Joseph's College, Bangalore, India
BOOK CHAPTERS & INVITED REVIEW ARTICLES
• V.K. Viswanathan, R. Sharma and G. Hecht. 2004. Microbes and their products - physiological effects upon mammalian mucosa. Advanced Drug Delivery Reviews 56 pp. 727-762.
• V.K. Viswanathan and G. Hecht. 2003. Enteropathogenic Escherichia coli induced alterations in epithelial barrier function. Archives of Hellenic Medicine. 20(A):26-29.
• J. Berkes, V. K. Viswanathan, S. Savkovic, and G. Hecht. 2003 Intestinal Epithelial Responses to Enteric Pathogens: Effects on the Tight Junction Barrier, Ion Transport, and Inflammation. Gut . 52(3):439-51.
• V.K. Viswanathan and G. Hecht. 2003. Epithelial cross talk with bacteria: Activation of the chloride secretory pathway. In Microbial Pathogens & the Intestinal Epithelial Cell. Ed. Gail Hecht. ASM press. Pp267-283.
• Cianciotto, N.P., S. Kurtz, K. Krcmarik, S. Mody, U. Prasad, M. Robey, J. Salerno and V. K. Viswanathan. 2001. Iron Requirement and Acquisition by Legionella pneumophila. In Legionella: Proceedings of the Fifth Intl Symposium. Ed. Reinhard Marre, et al. ASM Press.
• Viswanathan, V.K. and N.P.Cianciotto. 2001. Role of Iron Acquisition in Legionella pneumophila virulence. ASM News 5 (67).
• Viswanathan, V.K. and G. Hecht. 2000. Innate immunity and the gut. Curr opin gastroenterol. 16:546-551.
• Viswanathan, V.K. and N.P. Cianciotto. 2000. Electroporation of Legionella species. In Electro-transformation of Bacteria. Springer Verlag Publications, Heidelberg, Germany.
PRIMARY PUBLICATIONS
• F. L. Tomson, S. Savkovic, A. Koutsouris, V.K. Viswanathan and G. Hecht. 2004. Differential roles of PKC-zeta in Disruption of Tight Junction Barrier by Enteropathogenic and Enterohemorrhagic E. coli . Submitted to Gastroenterology. In press.
• V. K. Viswanathan, Sandra Lukic, Athanasia Koutsouris, Richard Miao, Michelle Muza and Gail Hecht. 2004. Cytokeratin 18 interacts with the enteropathogenic E. coli secreted protein EspF and is redistributed following infection. Cellular Microbiology. In press.
• V. K. Viswanathan, Athanasia Koutsouris, Sandra Lukic, Mark Pilkinton, Ivana Simonovic, Miljan Simonovic, and Gail Hecht . 2004 Comparative Analysis of EspF from Enteropathogenic and Enterohemorrhagic Escherichia coli in Alteration of Epithelial Barrier Function. Infection and Immunity. 72(6) 3218-3227.
• Viswanathan, V.K., S. Kurtz , L.L.Pedersen, Y. Abu-Kwaik, K. Krcmarik, S. Mody and N.P. Cianciotto. 2002. The cytochrome c maturation locus of Legionella pneumophila promotes iron assimilation and intracellular infection and contains a strain-specific insertion sequence element. Infection and Immunity . 70(4):1842-52.
• Viswanathan, V.K., K. Krcmarik and N.P. Cianciotto. 1999. Template secondary structure promotes polymerase jumping during PCR amplification. Biotechniques. 27(3):508-511.
• Viswanathan, V.K., P. Edelstein, C.D. Pope and N.P. Cianciotto. 1999. The Legionella pneumophila iraA Locus Promotes Virulence and Encodes a Protein with Similarity to Peptide Transporters. Infect Immun. 68: 1069-1079.
• Liles, M.R. V.K. Viswanathan and N.P. Cianciotto. 1998. Identification and Temperature Regulation of L. pneumophila Genes Involved in TypeIV Pilus Biogenesis and TypeII secretion. Infect. Immun. 66 (4) 1776-1782.
• Suter, T.M., V.K. Viswanathan and N.P. Cianciotto. 1997. Isolation of a Gene Encoding a Novel Spectinomycin Phosphotransferase from Legionella pneumophila . Antimicrob Agents and Chemotherapy 41:1385-1388.
• Viswanathan, V.K., J.M.Green, and B.P. Nichols. 1995. Kinetic Studies of 4-Amino 4-Deoxychorismate Synthase from Escherichia coli". Journal of Bacteriology, 177:5918-5923.
SECONDARY PUBLICATIONS
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