Nina Clark MD Assistant Professor of Medicine University of Illinois at Chicago Section of Infectious Diseases 808 S. Wood St. Rm 888 MC 735 Chicago, IL  60612 312-996-6732 (Ph) 312-413-1657 (FAX) nmclark@uic.edu

Education

Loyola University of Chicago, Chicago, Illinois, B.S.
University of Illinois College of Medicine, Chicago, Illinois, M.D.

Postdoctoral Training

Resident, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan
Fellow, Division of Infectious Diseases, University of Michigan, Ann Arbor, Michigan

Current Academic Appointment

Clinical Activities

Dr. Clark currently directs the Transplant Infectious Diseases program at UIC and works closely with the solid organ and bone marrow transplantation teams to assist in the management of infectious complications of transplantation. She is also Principal Investigator for the Ryan White CARE Act Title III Early Intervention Services (EIS) program at UIC that funds comprehensive primary health care for individuals living with HIV disease. She cares for persons with HIV at UIC and maintains an outreach HIV clinic in Chicago 's East Side neighborhood.

Areas of Research

During her research fellowship training, Dr. Clark's work predominantly focused on studying the host factors important for replication of the retroviruses HIV-1, HIV-2 and HTLV. Since being at UIC, her research has been in the area of pathogenesis and treatment of fungal infections, particularly in the transplant population and other high risk groups, such as intensive care unit patients. She has recently participated in several multicenter clinical trials studying the appropriate use of newer antifungal agents and clinical outcomes associated with their use. In addition, she has an ongoing investigator-initiated project studying Candida epidemiology at UIC and is developing several projects that focus on analyzing the host factors that predispose to infectious complications of solid organ and bone marrow transplantation.

Selected Publications

• Clark , N. M. , Pasternak, A., Braun, D.K., and Chenoweth, C. Primary cutaneous Nocardia otitidiscaviarum infection: Case report and review. Clin. Infect. Dis. 20:1266-1270, 1995.
• Clark, N. M. , Hannibal , M.C., and Markovitz, D. M. The peri- ? B site mediates human immunodeficiency virus type 2 enhancer activation in monocytes but not in T cells. J. Virology 69:4854-4862, 1995.
• Hedderwick , S.A. , Greenson, J.K., McGaughy, V.R., and Clark , N.M. Adenovirus cholecystitis in a patient with acquired immunodeficiency syndrome. Clin. Infect. Dis. 26:997-999, 1998.
• Clark , N.M. , Dieng Sarr, A., Sankalé, J.-L., Kanki, P.J., Kazanjian, P., Winfield, R., and Markovitz, D.M. Immunologic and virologic response of HIV-2 infection to antiretroviral therapy. AIDS 12:2506-2507, 1998
• Clark , N.M. Paecilomyces lilacinus infection in a heart transplant recipient and successful treatment with terbinafine. Clin. Infect. Dis. 28:1169-70, 1999.
• McNeil , S.A. , Clark , N.M. , Chandrasekar, P.H., and Kauffman , C.A. Successful treatment of vancomycin-resistant Enterococcus faecium bacteremia with linezolid after failure of Synercid (quinupristin/dalfopristin) treatment. Clin. Infect. Dis. 30:403-4, 2000.
• Smith, M.J., Gitlin , S.D. , Browning, C.M., Lane, B.R., Clark , N.M. , Shah, N., Rainier , S., and Markovitz, D.M. GLI-2 modulates retroviral gene expression. J. Virology 75:2301-2313, 2001.
• Browning, C.M., Smith, M.J., Clark , N.M. , Lane, B.R., Parada, C., Montano, M., Kewalramani, V.N., Littman, D.R., Essex , M., Roeder, R.G., and Markovitz, D.M. Human GLI-2 is a tat activation response element-independent tat cofactor. J. Virology 75:2314-2323, 2001.
• Clark , N.M. , Femino, J.E., and Chenoweth, C.E. Aeromonas infection after medicinal leech therapy: case reports and review. Infectious Diseases in Clinical Practice 10:211-218, 2001.
• Clark , N.M. and Lynch, J.P. Emerging infections in the intensive care unit (editorial). Seminars in Respiratory and Critical Care Medicine 24:1-2, 2003.
• Clark , N.M. and Chenoweth, C.E. Aeromonas hepatobiliary infection: report of 15 cases and review of the literature. Clin. Infect. Dis. 37:506-13, 2003.
• Clark , N.M. , Hershberger, E., Zervos, M.J., and Lynch, J.P. Antimicrobial resistance among gram-positive organisms in the intensive care unit. Current Opinion in Critical Care. 9:403-12, 2003.
• Clark , N.M. , Patterson, J., and Lynch, J.P. Antimicrobial resistance among gram-negative organisms in the intensive care unit. Current Opinion in Critical Care. 9:413-23, 2003.
• Singal, A., Malani, P.N., Day, L.J., Pagani, F.D., and Clark , N.M. Roseomonas infection associated with a left ventricular assist device: case report and review of the literature. Infection Control and Hospital Epidemiology. 24:963-5, 2003.
• Chan, L-N., Massad, M.G., Mahmood, K., Clark , N. , Steinhiser, S., Kpodonu, J., Tshibaka, C., and Jaffe, H.A. Severe hemorrhagic cystitis associated with BK polyomavirus infection following lung transplantation. Current Respiratory Medicine Reviews. 1:261-4, 2005.
• Jain, R., Linares-Diaz, M., Clark , N.M. , and Grim, S.A. The ideal antiretroviral agent: are we getting closer? Current Pharmaceutical Design. 12:1065-74, 2006.
• Day, L.J., Chenoweth, C.E., Vander Hyde, K., Lynch, J.P., Iannettoni, M., and Clark , N.M. Aspergillus infections following lung transplantation. Infectious Diseases in Clinical Practice. 14:283-8, 2006 .
• Grim, S.A. , Slover, C.M., Sankary, H., Oberholzer, J., Benedetti, E., and Clark , N.M. Risk factors for wound healing complications in sirolimus-treated renal transplant recipients. Transplantation Proceedings. 38:3520-3, 2006 .
• Clark , N.M. and Chenoweth, C.E. Streptococcal infections. In APIC Text of Infection Control and Epidemiology. Association for Professionals in Infections Control and Epidemiology 2005, 2 nd edition, Washington , DC , pp. 70-1 to 70-13.
• Clark , N.M. Legionella infections complicating lung and solid organ transplantation. In Lung and Heart-Lung Transplantation, Ed. Joseph P. Lynch and David Ross. Lung Health and Biology in Disease Series, Marcel Dekker, Inc. 2006, pp. 607-21.
• Lynch, J.P. and Clark , N.M. Atypical pneumonias. In Encyclopedia of Respiratory Medicine, Ed. Geoffery Laurent and Steven Shapiro, Elsevier Limited, Oxford , UK . 2006, pp. 410-16.