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University of Illinois College of Medicine at Chicago >> Education, Departments & Programs >> Departments >> Research >> Ayako Makino PhD

Ayako Makino, Ph.D.

Academic Title: Assistant Professor of Medicine

Administrative Positions:

Division: Endocrinology, Diabetes and Metabolism

Location: 1819 W. Polk St., MSB-E613, (MC 640), Chicago, IL 60612

Phone: (312)355-1018 (Office), 996-3962 (Lab) Fax: (312)413-0437



PhD, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan (2000)

Postdoctoral Fellow, Medical College of Wisconsin, Milwaukee, WI (2000-2002)

Postdoctoral Fellow, University of California, San Diego, CA (2002-2005)

Faculty Positions:

Clinical Specialties

Research Interests

Selected Publications

1. Makino A and Kamata K. Elevated plasma endothelin-1 level in streptozotocin-induced diabetic rats and responsiveness of the mesenteric arterial bed to endothelin-1. Br. J. Pharmacol. 123:1065-1072, 1998.

2. Makino A and Kamata K. Possible modulation by endothelin-1, nitric oxide, prostaglandin I2 and thromboxane A2 of vasoconstriction induced by an alpha-agonist in mesenteric arterial bed from diabetic rats. Diabetologia. 41:1410-1418, 1998.

3. Makino A, Ohuchi K and Kamata K. Mechanism underlying the attenuation of endothelium-dependent vasodilatation in the mesenteric arterial bed of the streptozotocin-induced diabetic rats. Br. J. Pharmacol. 130:549-556, 2000.

4. Makino A, Skelton MM, Zou A-P, Roman RJ and Cowley AW, Jr. Increased renal medullary oxidative stress produces hypertension. Hypertension. 39:667-672, 2002.

5. Makino A, Skelton MM, Zou A-P and Cowley AW, Jr. Increased renal medullary H2O2 leads to hypertension. Hypertension. 42:25-30, 2003.

6. Makino A, Glogauer M, Bokoch GM, Chien S and Schmid-Schönbein GW. Control of neutrophil pseudopods by fluid shear: The role of Rho family GTPases. Am. J. Physiol. Cell Physiol. 288:863-871, 2005.

7. Makino A, Prossnitz ER, Bünemann M, Wang JM, Yao W and Schmid-Schönbein GW. G protein-coupled receptors serve as mechanosensors for fluid shear stress in neutrophils. Am. J. Physiol. Cell Physiol. 290:1633-1639, 2006.

8. Makino A, Shin HY, Komai Y, Fukuda S, Coughlin M, Sugihara-Seki M and Schmid-Schönbein GW. Mechanotransduction in leukocyte activation. Biorheology. 44:221-249, 2007.

9. Makino A, Platoshyn O, Suarez J, Yuan JX and Dillmann WH. Downregulation of connexin40 is associated with coronary endothelial cell dysfunction in streptozotocin-induced diabetic mice. Am. J. Physiol. Cell Physiol. 295:221-230, 2008.

10. Makino A, Suarez J, Wang H, Belke DD, Scott B and Dillmann WH. Thyroid hormone receptor β is associated with coronary angiogenesis during pathological cardiac hypertrophy. Endocrinology. 150:2008-2015, 2009.

11. Li X, Zhang X, Leathers R, Makino A, Huang C, Parsa P, Marcias J, Yuan JX, Jamieson SW and Thistlethwaite PA. Notch3 signaling promotes the development of pulmonary arterial hypertension. Nat. Med. 15(11):1289-1297, 2009.

12. Makino A, Scott BT, and Dillmann WH. Mitochondrial fragmentation and superoxide anion production in coronary endothelial cells from a mouse model of type 1 diabetes. Diabetologia. 53(8):1783-1794, 2010.

13. Makino A, Suarez J, Gawlowski T, Han W, Wang H, Scott BT, and Dillmann WH. Regulation of Mitochondrial Morphology and Function by O-GlcNAcylation in Neonatal Cardiac Myocytes. Am. J. Physiol. Regul. Integr. Comp. Physio. 300:R1296-R1302, 2011.

14. Pangare M and Makino A. Mitochondrial function in vascular endothelial cell in diabetes. J. Smooth Muscle Res. 48:1-26, 2012.

15. Makino A, Wang H, Scott BT, Yuan JX and Dillmann WH. Thyroid Hormone Receptor α and Vascular Function. Am. J. Physiol. Cell Physiol. 302:C1346-C1352, 2012.

16. Shentu T-P, Singh DK, Oh M-J, Sun S, Sadaat L, Makino A, Mazzone T, Subbaiah P, Cho M and Levitan I. The role of oxysterols in control of endothelial stiffness. J. Lipid Res. 53(7):1348-1358, 2012.

17. Yamamura A, Guo Q, Yamamura H, Zimnicka AM, Pohl NM, Smith KA, Fernandez RA, Zeifman A, Makino A, Dong H and Yuan JX. Enhanced Ca2+-sensing receptor function in idiopathic pulmonary arterial hypertension. Circ. Res. 111(4):469-81, 2012.

18. Estrada IA, Donthamsetty R, Debski P, Zhou M-H, Zhang SL, Yuan JX, Han W and Makino A. STIM1 restores coronary endothelial function in type1 diabetic mice. Circ. Res. 111(9):1166-1175, 2012.

19. Yue L, Phillips S, Bian J-T, Makino A, and Mazzone T. Macrophage-derived ApoE co-localizes with endothelial cell cav-1 to modulate its association with eNOS and regulate NO production. Hypertension. 60(4):1040-6, 2012.

20. Sasaki K, Donthamsetty R, Heldak M, Scott BT, Makino A. VDAC: An old protein with new roles in diabetes. Am. J. Physiol. Cell Physiol. 303(10):C1055–C1060, 2012.