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University of Illinois College of Medicine at Chicago >> Education, Departments & Programs >> Departments >> Research >> Waddah A Alrefai MD

Waddah A. Alrefai, M.D.


Academic Title: Associate Professor of Medicine

Administrative Positions: Co-Chair, R&D Laboratory and Office Space Allocation Committee, Jesse Brown VA Medical Center

Division: Gastroenterology and Hepatology

Location: Jesse Brown VA Hospital Research Service, MP 151, 820 S. Damen Avenue, Chicago, IL 60612

Phone: (312)569-7429 (Office)  Fax: (312)569-8114

E-mail: walrefai@uic.edu



Education:

MD, University of Aleppo, Aleppo, Syria (1991)

Postdoctoral Fellow, Rush Cancer Institute, Rush University, Chicago, IL (1997-1998)

Postdoctoral Fellow, University of Illinois at Chicago, Chicago, IL (1998-2001)


Faculty Positions:

Instructor in Medicine, Department of Medicine, University of Illinois at Chicago, Chicago, IL (2001-2003)

Research Assistant Professor, Department of Medicine, University of Illinois at Chicago, Chicago, IL (2003-2005)

Assistant Professor, Department of Medicine, University of Illinois at Chicago, Chicago, IL (2005-2011)

Associate Professor of Medicine, Department of Medicine, University of Illinois at Chicago, Chicago, IL (2011-Present)


Clinical Specialties

Internal Medicine - Gastroenterology and Hepatology Research


Research Interests

Regulation of intestinal bile acid and cholesterol absorption

Cellular and molecular regulation of ASBT under physiological and pathophysiological conditions

Pegulation of the putative intestinal NPC1L1 cholesterol transporter

Molecular regulation of NPC1L1 expression at the transcriptional and the post-transcriptional levels

Role of NPC1L1 dysregulation in the pathophysiology of diseases associated with hypercholesterolemia



Selected Publications

1. Alrefai WA, Tyagi S, Gill RK, Saksena S, Mansour F, Hadjiagapiou C, Ramaswamy K and Dudeja PK.  Regulation of Butyrate Uptake in Caco2 Cells: Involvement of Monocarboxylate Transporter MCT-1. Am. J. Physiol. Gastrointest. Liver Physiol. 286(2):G197-203, 2004

2. Alrefai WA, Sarwar Z, Tyagi S, Saksena S, Dudeja PK and Gill RK.  Cholesterol Modulates Human Intestinal Sodium-Dependent Bile Acid Transporter.  Am. J. Physiol. Gastrointest. Liver Physiol. 288 (5): G978-85, 2005

3. Alrefai WA, Annaba F, Sarwar Z, Dwivedi A, Saksena S, Singla A, Dudeja PK and Ravinder K. Gill. Modulation of human Miemann-Pick C1 like 1 gene expression by sterol: Role Sterol Regulatory Element Binding Protein-2. Am. J. Physiol. Gastrointest. Liver Physiol. 292(1):G369-76. 2007

4. Alrefai WA, Saksena S, Tyagi S, Gill R, Ramaswamy K and Dudeja PK. Tuarodeoxycholic bile acid Inhibits Chloride Uptake in Caco2 Cells. Dig. Dis. Sci. 52(5):1270-8, 2007.

5. Alrefai WA, Wen X, Jiang W, Katz JP, Steinbrecher KA, Cohen MB, Williams IR, Dudeja PK and Wu GD.  Molecular Cloning and Promoter Analysis of Down-Regulated in Adenoma DRA. Am. J. Physiol. Gastrointest. Liver Physiol. 293(5):G923-34, 2007.

6. Annaba F, Ma K, Kumar P, Dudeja AK, Kineman R, Saksena S, Gill RK and Alrefai WA. Ileal Apical Sodium-Dependent Bile Acid Transport ASBT is Upregulated in Diabetes Mellitus Induced by Low-Doses of Streptozotocin in Rats. Am. J. Physiol. Gastrointest. Liver Physiol. 299 (4): G898-906, 2010.

7. Saksena S, Tyagi S, Goyal S, Gill RK, Alrefai WA, Ramaswamy K and Dudeja PK. Stimulation of Apical Cl-/HCO3-(OH-) Exchanger, SLC26A3 by Neuropeptide Y (NPY) is Lipid Raft Dependent. Am. J. Physiol. Gastrointest. Liver Physiol. 299 (6):G1334-43, 2010.

8. Saksena S, Goyal S, Raheja G, Singh V, Akhtar M, Nazir TM, Alrefai WA, Gill RK and Dudeja PK.  Upregulation of P-glycoprotein by probiotics in intestinal epithelial cells and in the dextran sulfate sodium model of colitis in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 300(6): G1115-23, 2011.

9. Kumar P, Malhotra P, Ma K, Singla A, Hedroug O, Saksena S, Dudeja PK, Gill RK and Alrefai WA.  SREBP2 mediates the modulation of Intestinal NPC1L1 Expression by Curcumin. Am. J. Physiol. Gastrointest. Liver Physiol. 301(1): G148-55, 2011.

10. Singla A, Kumar A, Priyamvada S, Tahniyath M, Saksena S, Gill RK, Alrefai WA and Dudeja PK. LPA Stimulates Intestinal DRA Gene Transcription via LPA2 Receptor, PI3K/AKT and c-fos Dependent Pathway. Am. J. Physiol. Gastrointest. Liver Physiol. 302(6): G618-27, 2012.

11. Sainz B Jr., Barretto N, Martin DN, Hiraga N, Imamura M, Hussain S, Marsh KA, Yu X, Chayama K, Alrefai WA, and Uprichard SL. The Niemann-Pick C1-Like 1 cholesterol absorption receptor: a novel hepatitis C virus entry factor and potential therapeutic target. Nat. Med. 18(2): 281-5, 2012.

12. Annaba F, Sarwar Z, Gill RK, Ghosh A, Saksena S, Borthakur A, Hecht GA, Dudeja PK and Alrefai WA.  Enteropathogenic E.coli (EPEC) infection inhibits ileal bile acid transporter ASBT. Am. J. Physiol. Gastrointest. Liver Physiol. 302(10):G1216-22, 2012.

13. Borthakur A, Priyamvada S, Kumar A, Natarajan AA, Gill RK, Alrefai WA and Dudeja PK.  A Novel Nutrient Sensing Mechanism Underlies Substrate-induced Regulation of Monocarboxylate Transporter 1. Am. J. Physiol. Gastrointest. Liver Physiol. 303 (10):G1126-33, 2012.

14. Malhotra P, Boddy C, Soni V, Saksena S, Dudeja PK, Gill RK and Alrefai WA. D-Glucose Modulates Intestinal Niemann-Pick C1 Like 1 (NPC1L1) Gene Expression via Transcriptional Regulation. Am. J. Physiol. Gastrointest. Liver Physiol. 304(2): G203-10, 2013.