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University of Illinois College of Medicine at Chicago >> Education, Departments & Programs >> Departments >> Research >> Evgeny V Berdyshev  PhD

Evgeny V. Berdyshev, Ph.D.


Academic Title: Assistant Professor of Medicine

Administrative Positions: Director, Lipidomics Research Facility

Division: Pulmonary, Critical Care, Sleep and Allergy Medicine

Location: 909 S. Wolcott Ave., COMRB 3111 (MC 719), Chicago, IL 60612

Phone: (312)355-5918 (Office), 355-5884 (Lab)

Fax: (312)996-7193

E-mail: eberdysh@uic.edu



Education:

PhD, Pacific Institute of Bioorganic Chemistry, Vladivostok, Russia (1989)


Faculty Positions:


Clinical Specialties


Research Interests


Selected Publications

  1. Berdyshev EV, Boichot E, Germin N, Allain N, Anger J-P and Lagente V.  Influence of fatty acid ethanolamides and D9-tetrahydrocannabinol on cytokine and arachidonate release by mononuclear cells. Eur. J. Pharmacol. 330, 231-240, 1997.
  2. Berdyshev EV.  Cannabinoid receptors and the regulation of immune response. Chem. Phys. Lipids. 108: 169-190, 2000.
  3. Petrache I, Natarajan V, Zhen L, Medler TR, Richter A, Cho C, Hubbard WC, Berdyshev EV and Tuder RB.  Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice. Nature Med. 11:491-498, 2005.
  4. Berdyshev EV, Gorshkova IA, Garcia JGN, Natarajan V and Hubbard WC.  Quantitative analysis of sphingoid base-1-phosphates as bisacetylated derivatives by liquid chromatography-tandem mass spectrometry. Anal. Biochem. 339:129-136, 2005.
  5. Berdyshev EV, Gorshkova IA, Usatyuk P, Zhao Y, Saatian B, Hubbard W and Natarajan V.  De novo biosynthesis of dihydrosphingosine-1-phosphate by sphingosine kinase 1 in mammalian cells. Cell. Signaling. 18: 1779-1792, 2006.
  6. Berdyshev EV, Gorshkova I, Skobeleva A, Bittman R, Lu X, Dudek SM, Mirzapoiazova T, Garcia JG and Natarajan V.  FTY720 inhibits ceramide synthases and upregulates dihydrosphingosine-1-phosphate formation in human lung endothelial cells. J. Biol. Chem. 284:5467-5477, 2009.
  7. Berdyshev EV, Goya J, Gorshkova I, Prestwich GD, Byun H-S, Bittman R and Natarajan V. Characterization of sphingosine-1-phosphate lyase activity by electrospray ionization-liquid chromatography/tandem mass spectrometry quantitation of (2E)-hexadecenal. Anal. Biochem. 408:12-18, 2011.
  8. Berdyshev EV. Mass spectrometry of fatty aldehydes. Biochim. Biophys. Acta. 1811:680-693, 2011.
  9. Mathew B, Jacobson JR, Berdyshev E, Huang Y, Sun X, Zhao Y, Gerhold LM, Siegler J, Evenoski C, Wang T, Zhou T, Zaidi R, Moreno-Vinasco L, Bittman R, Chen CT, Lariviere PJ, Sammani S, Lussier YA, Dudek SM, Natarajan V, Weichselbaum RE and Garcia JG. Role of sphingolipids in murine radiation-induced lung injury: protection by sphingosine 1-phosphate analogs. FASEB J. 25:3388-3400, 2011.
  10. Gorshkova I, Zhou T, Mathew B, Jacobson JR, Takekoshi D, Bhattacharya P, Smith B, Aydogan B, Weichselbaum RR, Natarajan V, Garcia JG and Berdyshev EV. Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression. J. Lipid Res. 53:1553-1568, 2012.