RESEARCH
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Patricia W. Finn, MD. Department Chair

© Copyright 2014 The Board of Trustees of the University of Illinois

Giuseppina Nucifora, Ph.D.


Academic Title: Professor of Medicine                                                                                        

Administrative Positions:

Division: Hematology and Oncology

Location: 909 S. Wolcott Ave., COMRB 5065 (MC 734), Chicago, IL 60612

Phone: (312)413-4686 (Office) Fax: (312)413-0548

E-mail: nucifora@uic.edu



Education:

PhD, University of Illinois at Chicago, Chicago, IL (1990)

Posdoctoral Fellow, University of Illinois at Chicago, Chicago, IL (1991-1996)


Faculty Positions:


Clinical Specialties


Research Interests


Selected Publications

  1. Li D, Sinha KK, Hay MA, Rinaldi CR, Saunthararajah Y and Nucifora G. RUNX1-RUNX1 homodimerization modulates RUNX1 activity and function. J. Biol. Chem. 282(18):13542-51, 2007.
  2. Senyuk V, Sinha KK, Li D, Rinaldi CR, Yanamandra S and Nucifora G. Repression of  RUNX1 activity by EVI1: a new role of EVI1 in leukemogenesis. Cancer Res. 67(12):5658-66, 2007.
  3. Laricchia-Robbio L and Nucifora G. Significant increase of self-renewal in hematopoietic cells after forced expression of EVI1. Blood Cells. Mol. Dis. 40(2):141-7, 2008.
  4. Cattaneo F and Nucifora G. EVI1 recruits the histone methyltransferase SUV39H1 for transcription repression. J. Biol. Chem. 105(2):344-52, 2008.
  5. Senyuk V, Rinaldi CR, Li D, Cattaneo F, Stojanovic A, Pane F, Du X, Mahmud N, Dickstein J and Nucifora G. Consistent up-regulation of Stat3 Independently of Jak2 mutations in a new murine model of essential thrombocythemia. Cancer Res. 69(1):262-71, 2009.
  6. Laricchia-Robbio L, Premanand K, Rinaldi CR and Nucifora G. EVI1 Impairs myelopoiesis by deregulation of PU.1 function. Cancer Res. 69(4):1633-42, 2009.
  7. Dickstein J, Senyuk V, Premanand K, Laricchia-Robbio L, Xu P, Cattaneo F, Fazzina R amd Nucifora G. Methylation and silencing of miRNA-124 by EVI1 and self-renewal exhaustion of hematopoietic stem cells in murine myelodysplastic syndrome. Proc. Natl. Acad. Sci. USA. 107(21):9783-8, 2010.
  8. Senyuk V, Premanand K, Xu P, Qian Z and Nucifora G. The oncoprotein EVI1 and the DNA methyltransferase Dnmt3 co-operate in binding and de novo methylation of target DNA. PLoS One. 6(6):e20793, 2011.
  9. Ming M, Wang S, Wu W, Senyuk V, Le Beau MM, Nucifora G and Qian Z. Activation of Wnt/β-catenin protein signaling induces mitochondria-mediated apoptosis in hematopoietic progenitor cells. J. Biol. Chem. 287(27):22683-90, 2012.
  10. Senyuk V, Zhang Y, Liu Y, Ming M, Premanand K, Zhou L, Chen P, Chen J, Rowley JD, Nucifora G and Qian Z. Critical role of miR-9 in myelopoiesis and EVI1-induced leukemogenesis. Proc. Natl. Acad. Sci. USA 110(14):5594-9, 2013.