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University of Illinois College of Medicine at Chicago >> Education, Departments & Programs >> Departments >> Research >> Ravinder K Gill, PhD

Jeffrey R. Jacobson, M.D.

Academic Title: Associate Professor of Medicine

Administrative Positions:

Division: Pulmonary, Critical Care, Sleep and Allergy Medicine

Location: 909 S. Wolcott Ave., COMRB 3141 (MC 719), Chicago, IL 60612

Phone: (312)355-5894 (Office) Fax: (312)996-7193



MD, New York University School of Medicine, New York, NY (1996)

Intern, New York University, New York, NY (1996-1997)

Resident, New York University, New York, NY (1997-1999)

Fellow, Johns Hopkins Hospital, Baltimore, MD (2000-2004)

Faculty Positions:

Clinical Specialties

Research Interests

Selected Publications

Book Chapters

1. Mahajan AK and Jacobson JR. Statins and Acute Lung Injury. In: “Textbook of Pulmonary Vascular Disease” First edition. Springer, New York, NY, 2011.

Original Research Articles

1. Chen W, Garcia JGN and Jacobson JR. Integrin β4 attenuates SHP-2 and MAPK signaling and reduces human lung endothelial inflammatory responses.  J. Cell. Biochem. 110(3): 718-24, 2010.

2. Mathew B, Huang Y, Jacobson JR, Berdyshev E, Gerhold LM, Wang T, Moreno-Vinasco L, Lang G, Zhao Y, Chen C, LaRiviere P, Mauceri H, Sammani S, Husain AN, Dudek SM, Natarajan V, Lussier YA, Weichselbaum RR and Garcia JGN. Simvastatin attenuates radiation-induced murine lung injury and dysregulated lung gene expression. Am. J. Physiol. Lung Cell. Mol. Physiol. 44(3):415-22, 2011.

3. Ma SF, Xie L, Pino-Yanes M, Sammani S, Wade MS, Letsiou E, Siegler J, Wang T, Infusino G, Kittles RA, Flores C, Zhou T, Prabhakar BS, Moreno-Vinasco L, Villar J, Jacobson JR, Dudek SM and Garcia JG. Type 2 Deiodase and host responses of sepsis in acute lung injury. Am. J. Respir. Cell Mol. Biol. 45(6):1203-11, 2011.

4. Mathew B, Jacobson JR, Berdyshev, Huang Y, Sun X, Zhao Y, Gerhold LM, Siegler J, Evenoski C, Wang T, Zhou T, Zaidi R, Moreno-Vinasco L, Bittman R, Chen CT, Lariviere PJ, Sammani S, Lussier YA, Dudek SM, Natarajan V, Weichselbaum RR and Garcia JG. Role of sphigolipids in murine radiation-induced lung injury: protection by sphingosine 1-phosphate analogs. FASEB J. 25(10):3388-400, 2011.

5. Mitra S, Sammani S, Wang T, Boone DL, Meyer NJ, Dudek SM, Moreno-Vinasco L, Garcia JG and Jacobson JR. Role of GADD45a in Akt phosphorylation and ubiquitination following mechanical stress-induced vascular injury. Am. J. Resp. Crit. Care Med. 184(9):1030-1040, 2011.

6. Infusino GA and Jacobson JR. Endohtelial FAK as a therapeutic target in disease. Microvasc. Res. 83(1):89-96, 2012.

7. Menkontso Dessap A, Voiriot G, Zhou T, Marcos E, Dudek SM, Jacobson JR, Machado R, Adnot S, Brochard L, Maitre B and Garcia JG. Conflicting physiological and genomic cardiopulmonary effects of recruitment maneuvers in murine acute lung injury. Am. J. Respir. Cell Mol. Biol 46(4):541-50, 2012.

8. Gorshkova I, Zhour T, Mathew B, Jacobson JR, Takekoshi D, Bhattacharya P, Smith B, Aydogan B, Weichselbaum RR, Natarajan V, Garcia JG and Berdyshev EV. Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression. J. Lipid Res. 53(8):1553-68, 2012.

9. Chen W, Sammani S, Mitra S, Ma SF, Garica JG and Jacobson JR. Critical role for integrin β4 in the attenuation of murine acute lung injury by simvastatin. Am. J. Respir. Cell Mol. Biol 303(4): L279-285, 2012.

10. Sun X, Singleton PA, Letsiou E, Zhao J, Belvitch P, Sammani S, Chiang ET, Moreno-Vinasco L, Wade MS, Zhou T, Liu B, Parastatidas I, Thomson L, Ischiropoulous H, Natarajan V, Jacobson JR, Machado RF, Dudek SM and Garcia JG. Sphingosine 1-phsophate receptor 3 is a novel biomarker in acute lung injury. Am. J. Respir. Cell Mol. Biol. 47(5):628-36, 2012.

11. Singla S and Jacobson JR. Statins as a novel therapeutic strategy in acute lung injury. Pulm. Circ. 2(4): 297-406, 2013.

12. Ephstein Y, Singleton P, Chen W, Wang L, Slagia R, Kanteti P, Dudek SM, Garia JGN and Jacobson JR. Critical role for S1PR1 and integrin β4 in HGF/c-Met-mediated increases in vascular integrity. J. Biol. Chem. 288(4): 2191-200, 2013.