RESEARCH
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Patricia W. Finn, MD. Department Chair

© Copyright 2014 The Board of Trustees of the University of Illinois

Jaleh Malakooti, Ph.D.


Academic Title: Assistant Professor of Medicine

Division: Gastroenterology and Hepatology

Location: 840 S. Wood St., (MC 716), Chicago, IL 60612

Phone: (312)996-1561 (Office) Fax: (312)996-5103

E-mail: malakoot@uic.edu






Education:

PhD, University of Illinois at Chicago, Chicago, IL (1989)

Postdoctoral Fellow, University of South Carolina, Columbia, SC (1989-1991)


Faculty Positions:


Clinical Specialties


Research Interests


Selected Publications

  1. Cuff MA, Shirazi-Beechey SP, Dudeja PK, Malakooti J and Ramaswamy K.  The Human Monocarboxylate Transporter MCT1: Gene Structure and Regulation. Am. J. Physiol. Gastrointest. Liver Physiol. 289:G977-G979, 2005.
  2. Gill RK, Saksena S, Tyagi S, Alrefai WA, Malakooti J, Turner J, Ramaswamy K and Dudeja PK. Serotonin inhibits Na+/H+ exchange activity via 5-HT4 receptor subtypes and activation of PKCa in Caco-2 cells. Gastroenterology. 128:962-74, 2005.
  3. Malakooti J, Sandoval R, Memark VC, Dudeja PK and Ramaswamy K. Zinc finger transcription factor Egr-1 is involved in stimulation of NHE2 gene expression by phorbol 12-myristate 13-acetate.  Am. J. Physiol. Gastrointest. Liver Physiol. 289(4):G653-63, 2005.
  4. Amin MR, Malakooti J, Sandoval R, Dudeja PK and Ramaswamy K.  IFN-gamma and TNF-alpha regulate human NHE3 gene expression by modulating the Sp family transcription factors in human intestinal epithelial cell line C2BBe1.  Am. J. Physiol. Cell. Physiol. 291(5):C887-96, 2006.
  5. Malakooti J, Sandoval R, Amin MR, Clark J, Dudeja PK, Ramaswamy K. Transcriptional stimulation of the human NHE3 promoter activity by PMA: PKC independence and involvement of the transcription factor EGR-1. Biochem. J. 396(2):327-36, 2006.
  6. Amin MR, Dudeja PK, Ramaswamy K and Malakooti J.  Involvement of Sp1 and Sp3 in differential regulation of human NHE3 promoter activity by sodium butyrate and IFN-gamma/TNF-alpha. Am. J. Physiol. Gastrointest. Liver Physiol. Jul; 293(1):G374-82, 2007.
  7. Pearse I, Zhu YX, Murray EJ, Dudeja PK, Ramaswamy K and Malakooti J.  Sp1 and Sp3 control constitutive expression of the human NHE2 promoter by interactions with the proximal promoter and the transcription initiation site. Biochem. J. 407:101-111, 2007.
  8. Saksena S, Dwivedi A, Gill R, Singla A, Alrefai W, Malakooti J, Ramaswamy K and Dudeja P. PKC-dependent Stimulation of the Human MCT1 Promoter Involves Transcription Factor AP2. Am. J. Physiol. Gastrointest. Liver Physiol. 296:G275-283, 2009.
  9. Amin MR, Ghannad L, Othman A, Gill RK, Dudeja PK, Ramaswamy K and Malakooti J. Transcriptional regulation of the human Na+/H+ exchanger NHE3 by serotonin in intestinal epithelial cells. Biochem. Biophys. Res. Commun. 382:620-625, 2009.
  10. Amin MR, Orenuga T, Tyagi S, Dudeja PK, Ramaswamy K and Malakooti J. Tumor necrosis factor-alpha represses the expression of NHE2 through NF-kappaB activation in intestinal epithelial cell model, C2BBe1. Inflamm. Bowel Dis. 17:720-731, 2011.
  11. Gill RK, Anbazhagan AN, Esmaili A, Kumar A, Nazir S, Malakooti J, Alrefai WA and Saksena S.  Epidermal growth factor upregulates serotonin transporter in human intestinal epithelial cells via transcriptional mechanisms. Am. J. Physiol. Gastrointest. Liver Physiol. 300:G627-36, 2011.
  12. Malakooti J, Saksena S, Gill RK and Dudeja PK. Transcriptional regulation of the intestinal luminal Na⁺ and Cl⁻ transporters. Biochem. J. 435:313-25, 2011.
  13. Muthusamy S, Shukla S, Amin MR, Cheng M, Orenuga T, Dudeja PK and Malakooti J. PKCδ-dependent Activation of ERK1/2 Leads to Upregulation of the Human NHE2 Transcriptional Activity in Intestinal Epithelial Cell Line C2BBe1. Am. J. Physiol. Gastrointest. Liver Physiol. 302:G317-25, 2012.
  14. Singh V, Raheja G, Borthakur A, Kumar A, Gill RK, Alakkam A, Malakooti J and Dudeja PK. Lactobacillus acidophilus Upregulates Intestinal NHE3 Expression and Function. Am. J. Physiol. Gastrointest. Liver Physiol. 303:G1393-401, 2012.