RESEARCH
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Patricia W. Finn, MD. Department Chair

© Copyright 2014 The Board of Trustees of the University of Illinois

Joanne K. Tobacman, M.D.


Academic Title: Associate Professor of Clinical Medicine

Administrative Positions:

Division: General Internal Medicine

Location: 840 S. Wood St., Room 440 (MC 718), Chicago, IL 60612

Phone: (312)569-7826 (Office) Fax: (312)413-8283

E-mail: jkt@uic.edu





Education:

MD, Case Western Reserve University School of Medicine, Cleveland, OH (1976)

Intern, University Hospitals of Cleveland, OH (1976-1977)

Junior Assistant Resident, Medicine, University Hospitals of Cleveland, Cleveland, OH (1978-1979)


Faculty Positions:


Clinical Specialties


Research Interests


Selected Publications

  1. Tobacman JK, Zimmerman B, Lee PP, Hilborne L, Kolder H and Brook RH.  Visual acuity following cataract surgeries in relation to preoperative appropriateness ratings.  Med. Decis. Making. 23:122-130, 2003.
  2. Tobacman JK.  Does deficiency of arylsulfatase B have a role in cystic fibrosis?  Chest. 123(6):2130-2139, 2003.
  3. Tobacman JK, Kissinger P, Wells M, Prokuski J, Hoyer M, McPherson P, Wheeler J, Kron-Chalupa J, Parsons C, Weller P, Zimmerman B.  Implementation of personal health records by nurse case managers in a VAMC general medicine clinic.  Patient Educ. Couns. 54(1):27-33, 2004.
  4. Bhattacharyya S and Tobacman JK.  Steroid sulfatase, arylsulfatases A and B, galactose 6-sulfatase, and iduronate sulfatase in mammary cells and effects of sulfated and non-sulfated estrogens on sulfatase activity. J. Steroid Biochem. Mol. Biol. 103(1):20-34, 2007.
  5. Bhattacharyya S, Borthakur A, Dudeja PK and Tobacman JK. Carrageenan reduces bone morphogenetic protein-4 (BMP4) and activates Wnt/β-catenin pathway in normal human colonic epithelial cells. Dig. Dis. Sci. 52(10):2766-74, 2007.
  6. Bhattahcharyya S, Dudeja PK and Tobacman JK.  Lipopolysaccharide activates NFκB by TLR4-Bcl10 dependent and independent pathways in colonic epithelial cells. Am J Physiol Gastrointest Liver Physiol. 295(4):G784-90, 2008.
  7. Tobacman JK, Bhattacharyya S, Borthakur A and Dudeja PK.  The carrageenan diet:  not recommended.  Science. 321(5892):1040-1, 2008.
  8. Bhattacharyya S and Tobacman JK.  Arylsulfatase B regulates colonic epithelial cell migration by effects on MMP9 expression and RhoA activation.  Clin. Exp. Metastasis. 26(6):535-45, 2009.
  9. Bhattacharyya S, Liu H, Zhang Z, Jam M, Dudeja PK, Michel G,  Linhardt RJ and Tobacman JK. Carrageenan-induced innate immune response is modified by enzymes that hydrolyze distinct galactosidic bonds. J. Nutr. Biochem. 21(10):906-13, 2010.
  10. Prabhu SV, Bhattacharyya S, Guzman-Hartman G, Macias V, Kajdacsy-Balla A and Tobacman JK. Extra-Lysosomal Localization of Arylsulfatase B in Human Colonic Epithelium. J. Histochem. Cytochem. 59(3):328-335, 2011.
  11. Bhattacharyya S, Borthakur A, Anbazhagan AN, Katyal S, Dudeja PK and Tobacman JK. Specific effects of BCL10 serine mutations on phosphorylations in canonical and non-canonical pathways of NF-κB activation following carrageenan. Am. J. Physiol. Gastrointest. Liver Physiol. 301(3):G475-86, 2011.
  12. Bhattacharyya S, O-Sullivan I, Katyal S, Unterman T and Tobacman JK. Exposure to the common food additive carrageenan leads to glucose intolerance, insulin resistance and inhibition of insulin signaling in HepG2 cells and C57BL/6J mice. Diabetologia. 55(1):194-203, 2012.
  13. Bhattacharyya S and Tobacman JK. Molecular signature of kappa-carrageenan mimics chondroitin-4-sulfate and dermatan sulfate and enables interaction with arylsulfatase B. J. Nutr. Biochem. 23(9)1058-63, 2012.
  14. Bhattacharyya S and Tobacman JK.  Hypoxia reduces arylsulfatase B activity and silencing arylsulfatase B replicates and mediates the effects of hypoxia.  PLoS One. 7(3):e33250, 2012.