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University of Illinois College of Medicine at Chicago >> Education, Departments & Programs >> Departments >> Research >> Jason X J Yuan MD PhD

Jason X.-J. Yuan, M.D., Ph.D.

Academic Title: Professor of Medicine and Pharmacology

Administrative Positions: Vice Chair for Scholarly Activities, Department of Medicine; Director, Pulmonary Hypertension Translational Research Program, IPRM; Director, Program in Pulmonary Vascular Disease and Right Heart Function, CCVR

Division: Pulmonary, Critical Care, Sleep and Allergy Medicine

Location: 909 S. Wolcott Ave., COMRB 3131 (MC 719), Chicago, IL 60612

Phone: (312)355-5911 (Office), 355-5912 (Lab) Fax: (312)996-7193



MD, Suzhou Medical College, Suzhou, China (1983)

Postdoctoral Fellow, University of Maryland, Baltimore, MD (1988-1991)

Ph.D., Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China (1993)

Faculty Positions:

Clinical Specialties

Research Interests

Selected Publications


  1. Yuan JX (ed): Hypoxic Pulmonary Vasoconstriction: Cellular and Molecular Mechanisms. Kluwer Academic Publishers, Boston, MA, 2004.
  2. Yuan JX (ed): Ion Channels in the Pulmonary Vasculature. Taylor & Francis Group, Boca Raton, FL, 2005.
  3. Yuan JX and Ward JPT (eds) Membrane Receptors, Channels, and Transporters in Pulmonary Circulation. Humana Press-Springer, New York, NY, 2010.
  4. Yuan JX, Garcia JGN, Hales CA, Rich S, Archer SL and West JB (eds): Textbook of Pulmonary Vascular Disease. Springer, New York, NY, 2011.

Review Articles

  1. Mandegar M, Fung Y-CB, Huang W, Remillard CV, Rubin LJ, and Yuan JX. Cellular and molecular mechanisms of pulmonary vascular remodeling: Role in the development of pulmonary hypertension.  Microvasc. Res. 68(2):75-103, 2004.
  2. Burg ED, Remillard CV, and Yuan JX. Potassium channels in the regulation of pulmonary artery smooth muscle cell proliferation and apoptosis. Br. J. Pharmacol. 153(S1):S99-S111, 2008.
  3. Firth AL, Remillard CV, Platoshyn O, Fantozzi I, Ko EA, and Yuan JX. Functional ion channels in human pulmonary artery smooth muscle cells: Voltage-dependent cation channels. Pulm. Circ. 1:49-72, 2011.
  4. Makino A, Firth AL, and Yuan J.X. Endothelial and smooth muscle cell ion channels in pulmonary vasoconstriction and vascular remodeling. Compr. Physiol. 1:1555-1602, 2011.
  5. Kuhr FK, Smith KA, Song MY, Levitan I, and Yuan JX. New mechanisms of pulmonary hypertension: Role of Ca2+ signaling. Am. J. Physiol. Heart Circ. Physiol. 302:H1546-H1562, 2012.

Original Research Articles

  1. Yu Y, Keller SH, Remillard CV, Safrina O, Nicholson A, Zhang SL, Jiang W, Vangala N, Landsberg JW, Wang J-Y, Thistlethwaite PA, Channick RN, Robbins IM, Loyd JE, Ghofrani HA, Grimminger F, Schermuly RT, Cahalan MD, Rubin LJ and Yuan JX. A functional single nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension. Circulation 119:2313-2322, 2009.
  2. Yao W, Firth AL, Sacks RS, Ogawa A, Auger WR, Fedullo PF, Madani MM, Sakakibara N, Lin GY, Thistlethwaite PA, Jamieson SW, Rubin LJ, Yuan JX. Identification of putative endothelial progenitor cells (CD34+CD133+Flk-1+) in endarterectomized tissue of patients with chronic thromboembolic pulmonary hypertension. Am. J. Physiol. Lung Cell. Mol. Physiol. 296:L870-L878, 2009.
  3. Li X, Zhang X, Leathers R, Makino A, Huang C, Parsa P, Macias J, Yuan JX, Jamieson SW and Thistlethwaite PA. Notch3 signaling promotes the development of pulmonary arterial hypertension. Nat. Med. 15(11):1289-1297, 2009.
  4. Burg ED, Platoshyn O, Tsigelny IF, Lozano-Ruiz B, Rana BK and Yuan JX. Tetramerization domain mutations in KCNA5 affect channel kinetics and cause abnormal trafficking patterns. Am. J. Physiol. Cell Physiol. 298:C496-C509, 2010.
  5. Firth AL, Yao W, Remillard CV, Ogawa A and Yuan JX. Upregulation of Oct-4 isoforms in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension. Am. J. Physiol. Lung Cell. Mol. Physiol. 298:L548-L557, 2010.
  6. Firth AL, Yao W, Ogawa A, Madani MM, Lin GY and Yuan JX. Multipotent mesenchymal progenitor cells are present in endarterectomized tissues from patients with chronic thromboembolic pulmonary hypertension. Am. J. Physiol. Cell Physiol. 298:C1217-C1225, 2010.
  7. Ogawa A, Firth AL, Smith KA, Maliakal MV, and Yuan JX. PDGF enhances store-operated Ca2+ entry by upregulating STIM1/Orai1 via activation of Akt/mTOR in human pulmonary arterial smooth muscle cells. Am. J. Physiol. Cell Physiol. 302:C405-C411, 2012.
  8. Desai AA, Zhou T, Ahmad H, Zhang W, Mu W, Trevino S, Wade MS, Raghavachari N, Kato GJ, Peters-Lawrence MH, Thiruvoipati T, Turner K, Artz N, Huang Y, Patel AR, Yuan JX, Gordeuk VR, Lang RM, Garcia JGN, and Machado RF. A novel molecular signature for elevated tricuspid regurgitation velocity in sickle cell disease. Am. J. Respir. Crit. Care Med. 186(4):359-368, 2012.
  9. Yamamura A, Guo Q, Yamamura H, Zimnicka AM, Pohl NM, Smith KA, Fernandez RA, Zeifman A, Makino A, Dong H, and Yuan JX. Enhanced Ca2+-sensing receptor function in pulmonary arterial hypertension. Circ. Res. 111:469-481, 2012.