RESEARCH
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Patricia W. Finn, MD. Department Chair

© Copyright 2014 The Board of Trustees of the University of Illinois

Larry S. Tobacman, M.D.


Academic Title: Professor of Medicine and Physiology & Biophysics

Administrative Positions: Senior Associate Dean for Research, College of Medicine; Director, Medical Scientist Training Program; Associate Director, Center for Clinical and Translational Science

Division: Cardiology

Location: 1853 W. Polk St., (MC 784), Chicago, IL 60612

Phone: (312)413-9688 (Office), 413-7855 (Lab) Fax: (312)996-9006

E-mail: LST@uic.edu




Education:

MD, Case Western Reserve University, Cleveland, OH (1976)

Intern/Resident, Case Western Reserve University Hospitals, Cleveland, OH (1976-1979)

Fellow, Laboratory of Molecular Cardiology, NHLBI, Bethesda, MD (1982-1986)


Faculty Positions:


Clinical Specialties


Research Interests


Selected Publications

  1. Tobacman LS, Nili M, Butters C, Heller V, Craig R, Lehman W and Homsher E. The Troponin Tail Domain Promotes a Conformational State of the Thin Filament That Suppresses Myosin Activity. J. Biol. Chem. 277(31):27636-42, 2002.
  2. Li Y, Mui S, Brown JH, Strand J, Reshtnikova L, Tobacman LS and Cohen C. The crystal structure of the C-terminal of striated muscle α-Tropomyosin reveals a key troponin T recognition site. Proc. Natl. Acad. Sci. 99:7378-7383, 2002.
  3. Heller M, Tobacman LS, Nili M and Homsher E. Cardiomyopathy Mutations that Increase Calcium-sensitivity and Tropomyosin N-Domain Flexibility. J. Biol. Chem. 278: 41742-41748, 2003.
  4. Brown JH, Zhou Z, Reshetnikova L, Robinson H, Yammani RA, Tobacman LS and Cohen C. Structure of Tropomyosin's Mid-Region: Bending and Binding Sites for Actin. Proc.Natl.Acad.Sci. 102:18878-83, 2005.
  5. Gong H, Hatch V, Ali L, Lehman W, Craig R and Tobacman LS. Mini-Thin Filaments Regulated by Troponin-Tropomyosin. Proc. Natl. Acad. Sci., 102: 656-661, 2005.
  6. Galinska-Rakoczy A, Engel P, Xu C, Jung H, Craig R, Tobacman LS and Lehman W. Structural Basis for the Regulation of Muscle Contraction by Troponin and Tropomyosin. J. Mol. Biol. 379: 929–935, 2008.
  7. Sithanandan V, Tobacman LS, Van Gorder N and Homsher E. Mechanical and kinetic effects of shortened tropomyosin reconstituted into myofibrils. Pflügers Arch. 458: 761-76, 2009.
  8. Ali LF, Cohen JM and Tobacman LS. Push and Pull of Tropomyosin's Opposite Effects on Myosin Attachment to Actin. A Chimeric Tropomyosin Host-Guest Study.  Biochem. 49: 10873-10880, 2010.
  9. Kowlessur D, and Tobacman LS. Low Temperature Dynamic Mapping Reveals Unexpected Order and Disorder in Troponin. J. Biol. Chem. 285: 38978-38986, 2010.
  10. Kozaili JM, Leek D, and Tobacman LS. Dual Regulatory Functions of the Thin Filament Revealed by Replacement of the Troponin I Inhibitory Peptide with a Linker. J. Biol. Chem. 285: 38034-38041, 2010.
  11. Kowlessur D and Tobacman LS. Troponin Regulatory Function and Dynamics Revealed by H/D Exchange-Mass Spectrometry. J. Biol. Chem. 285: 2686-2694, 2010.
  12. Sousa D, Cammarato A, Jang K, Graceffa P, Tobacman LS, Li XE, and Lehman W. Electron microscopy and persistence length analysis of semi-rigid smooth muscle tropomyosin strands. Biophys. J. 99: 862-868, 2010.
  13. Li XE, Tobacman LS, Mun JY, Craig R, Fischer S, and Lehman W. Position on F-actin Revealed by EM Reconstruction and Computational Chemistry.  Biophys. J. 100: 1005-10013, 2011.
  14. Kowlessur D, and Tobacman LS. Significance of Troponin Dynamics for Ca2+-Mediated Regulation of Contraction and Inherited Cardiomyopathy. J. Biol. Chem. 287: 42299-42311, 2012.