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University of Illinois College of Medicine at Chicago >> Education, Departments & Programs >> Departments >> Research >> Lei Xiao MD PhD

Lei Xiao, M.D., Ph.D.


Academic Title: Assistant Professor of Medicine

Administrative Positions: Director, Research Education

Division: Pulmonary, Critical Care, Sleep and Allergy Medicine

Location: 840 S. Wood St., Room 805 (MC 719), Chicago, IL 60612

Phone: (312)996-9078 (Office), 996-0093 (Lab) Fax: (312) 996-4665

E-mail: leixiao@uic.edu






Education:

MD, Beijing Medical University (currently Peking University Health Science Center), Beijing, China (1993)

Intern, The Third Affiliated Hospital of Beijing Medical University, Beijing, China (1992-1993)

Resident, Cardiovascular Institute & Fuwai Hospital of Chinese Academy of Medical Sciences, Beijing, China (1993)

PhD, Creighton University, Omaha, NE (1998)

Postdoctoral Fellow, Boston University School of Medicine Boston, Massachusetts (1998-2001)


Faculty Positions:


Clinical Specialties


Research Interests


Selected Publications and Presentations

  1. Amin JK, Xiao L, Pimental DR, Patrick PJ, Sawyer DB, Colucci WS. Reactive oxygen species mediate alpha-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes. J. Mol. Cell. Cardiol. 33:131-139, 2001.
  2. Xiao L, Pimental DR, Amin JK, Singh K, Sawyer DB, and Colucci WS. MEK1/2-ERK1/2 mediates a1-adrenergic receptor stimulated hypertrophy in adult rat ventricular myocytes. J. Mol. Cell. Cardiol. 33:779-787, 2001.
  3. Pimentel DR, Amin JK, Xiao L, Miller T, Viereck J, Oliver-Krasinski J, Baliga R, Wang J, Siwik DA, Singh K, Pagano P, Colucci WS, and Sawyer DB. Reactive oxygen species mediate amplitude-dependent hypertrophic and apoptotic responses to mechanical stretch in cardiac myocytes. Circ. Res. 89:453-460, 2001.
  4. Xiao L, Pimentel DR, Wang J, Singh K, Colucci WS, and Sawyer DB. Role of reactive oxygen species and NAD(P)H oxidase in a1-adrenoceptor signaling in adult rat cardiac myocytes. Am J Physiol Cell Physiol. 282:C926-C934, 2002.
  5. Maytin M, Siwik DA, Ito M, Xiao L, Sawyer DB, Liao R, and Colucci WS. Pressure overload-induced myocardial hypertrophy in mice does not require gp91phox. Circulation 109(9):1168-71, 2004.
  6. Xiao L, Zhao Q, Du Y, Chao Y, Solaro RJ, and Buttrick PM. PKCe increases phosphorylation of cardiac myosin binding protein C at serine302 both in vitro and in vivo. Biochemistry. 46(23):7054-7061, 2007.
  7. Cao H, Xiao L, Park G, Wang X, Azim A, Christman JW, and van Breemen RB: An improved LC–MS/MS method for the quantification of prostaglandins E2 and D2 production in biological fluids. Anal Biochem. 372(1):41-51, 2008.
  8. Yu R, Xiao L, Zhao G, Christman JW, and van Breemen RB. Competitive enzymatic interactions contributing to the relative production of prostaglandins E2 and D2. J. Pharmacol. Exp. Ther. 339(2):716-725. 2011.  
  9. Karpurapu M, Wang M, Deng J, Park H, Xiao L, Sadikot RT, Frey RS, Maus UA, Park GY, Scott E, and Christman JW. Functional PU.1 in macrophages has a pivotal role in NF-kB activation and neutrophilic lung inflammation during endotoxemia. Blood. 118(19):5255-66, 2011.
  10. Deng J, Wang X, Qian F, Vogel S, Xiao L, Ranjan R, Park H, Karpurapu M, Frey RS, Park GY, Ye RD, and Christman JW. Protective role of reactive oxygen species in endotoxin-induced lung inflammation through modulation of IL-10 expression. J Immunol. 188(11):5734-40, 2012.
  11. Xiao L, Ornatowska M, Zhao G, Cao H, Yu R, Deng J, Li Y, Zhao Q, Sadikot R, and Christman JW. Lipopolysaccharide-induced expression of microsomal prostaglandin E synthase-1 mediates late-phase PGE2 production in bone marrow derived macrophages. PLoS One. 7(11):e50244, 2012.
  12. Zhao G, Yu R, Deng J, Zhao Q, Christman JW, van Breemen RB, and Xiao L. Pivotal role of reactive oxygen species in regulating lipopolysaccharide-induced prostaglandin D2 production in macrophages. Mol. Pharmacol. 83(1):167-78, 2013.