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Patricia W. Finn, MD. Department Chair

© Copyright 2014 The Board of Trustees of the University of Illinois

Marcelo G. Bonini, Ph.D.

Academic Title: Assistant Professor of Medicine, Pharmacology and Pathology

Administrative Positions: Director, Oxidative Stress Core

Division: Cardiology

Location: 909 S. Wolcott Ave., COMRB 1135, Chicago, IL 60612

Phone: (312)355-5948 (Office), 996-4741 (Lab) Fax: (312)996-9006



PhD, University of Sao Paulo, Sao Paulo, Brazil (2004)

Postdoctoral Fellow, National Institutes of Health, Research Triangle Park, NC (2004-2009)

Faculty Positions:

Clinical Specialties

Research Interests

Selected Publications

1. Bonini MG, Stadler K, Silva SO, Corbett J, Dore M, Petranka J, Fernandes DC, Tanaka LY, Duma D, Laurindo FR and Mason RP. Constitutive nitric oxide synthase activation is a significant route for nitroglycerin-mediated vasodilation. Proc. Natl. Acad. Sci. USA. 105(25):8569-74, 2008.

2. Bonini MG, Gabel SA, Ranguelova K, Stadler K, Derose EF, London RE and Mason RP. Direct magnetic resonance evidence for peroxymonocarbonate involvement in the cu,zn-superoxide dismutase peroxidase catalytic cycle. J. Biol. Chem. 284(21):14618-27, 2009.

3. Hickok JR, Sahni S, Mikhed Y, Bonini MG and Thomas DD. Nitric oxide suppresses tumor cell migration through N-Myc downstream-regulated gene-1 (NDRG1) expression: role of chelatable iron. J. Biol. Chem. 286(48):41413-24, 2011.

4. Mao M, Sudhahar V, Ansenberger-Fricano K, Fernandes DC, Tanaka LY, Fukai T, Laurindo FR, Mason RP, Vasquez-Vivar J, Minshall RD, Stadler K and Bonini MG. Nitroglycerin drives endothelial nitric oxide synthase activation via the phosphatidylinositol 3-kinase/protein kinase B pathway. Free Radic. Biol. Med. 52(2):427-35, 2012.

5. Davies MF, Zhou L, Ehrenshaft M, Ranguelova K, Gunawardena HP, Chen X, Bonini MG, Mason RP and Campbell SL. Detection of Ras GTPase protein radicals through immunospin-trapping. Free Radic. Biol. Med. 53: 1339-1345, 2012.

6. Towner RA, Smith N, Saunders D, Henderson M, Downum K, Lupu F, Silasi-Mansat R, Ramirez D, Gomez-Mejiba S, Bonini MG, Ehrenshaft M and Mason RP. In vivo Detection of protein radicals with molecular MRI in a mouse diabetes model. Diabetes. 61: 2405-2413, 2012.

7. Mason RP, Ganini D, Bonini MG and Ranguelova K. Two hypothesis for the oxidation of SOD1-Cu(I). Free Radic. Biol. Med. 53; 1991-1992, 2012.

8. Ansenberger-Fricano K, Mao M, Chatterjee S, Dallas S, Green P, Mason RP, Santos JH and Bonini MG. The peroxidase activity of manganese superoxide dismutase MnSOD/SOD2. Free Radic. Biol. Med. 54: 116-124, 2013.

9. Sieracki NA, Gantner B, Malik AB and Bonini MG. Bioluminescent detection of peroxynitrite with a boronic acid luciferin. Free Radic. Biol. Med. 61C:40-50, 2013.

10. Hobbs GA, Bonini MG, Gunawardena HP, Chen X and Campbell SL. Glutathiolated Ras: Characterization and Implications for Ras activity. Free Radic. Biol. Med. 57:221-229, 2013.

11. Sovari AA, Rutledge CA, Jeong EM, Dolmatova E, Arasu D, Liu H, Vahdani N, Gu L, Zandieh S, Xiao L, Bonini MG, Duffy HS and Dudley SC. Mitochondrial oxidative stress, Connexin-43 remodeling and sudden arrhythmic death. Circ. Arrhythm. Electrophysiol. Epub ahead of print, 2013.