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University of Illinois College of Medicine at Chicago >> Education, Departments & Programs >> Departments >> Research >> Nadim Mahmud Md PhD

Nadim Mahmud, M.D., Ph.D.


Academic Title: Associate Professor of Medicine and Bioengineering

Administrative Positions: Director, Clinical Stem Cell Laboratory, Blood & Marrow Transplant Program

Division: Hematology and Oncology

Location: 909 S. Wolcott Ave., COMRB 7113 (MC734), Chicago, IL 60612

Phone: (312)413-9183 (Office), 996-1602 (Lab) Fax: (312)413-7963

E-mail: nadim@uic.edu


Education:

MD, University of Chittagong, Chittagong Medical College, Chittagong, Bangladesh (1989)

Intern, Chittagong Medical College Hospital, Chittagong, Bangladesh (1989-1990)

Ph.D., Mie University School of Medicine, Mie, Japan (1996)

Postdoctoral Fellow, Mie University School of Medicine, Mie, Japan  (1996-1998)

Postdoctoral Fellow, University of Illinois at Chicago, Chicago, IL (1998-2000)


Faculty Positions


Clinical Specialties


Research Interests


Selected Publications

1. Mahmud N, Devine SM, Weller KP, Parmar S, Sturgeon C, Nelson MC, Hewett T and Hoffman R. The Relative Quiescence of Hematopoietic Stem Cells in Non-Human Primates. Blood. 97:3061-8.1, 2001.

2. Mahmud N, Pang W, Cobbs C, Alur P, Borneman J, Dodds R, Archambault M, Devine S, Turian J, Bartholomew A, Vanguri P, Mackay A, Young R and Hoffman R. Studies of the Route of Administration and Role of Conditioning with Radiation on Unrelated Allogeneic Mismatched Mesenchymal Stem Cell Engraftment in a Non-Human Primate Model. Exp. Hematol. 32:494-501, 2004.

3. Milhem M, Mahmud N, Lavelle D, Araki H, DeSimone J, Saunthararajah Y and Hoffman R. Modification of Hematopoietic Stem Cell Fate By 5aza 2’deoxycytidine and Trichostatin A. Blood.103:4102-4110, 2004.

4. Mahmud N, Rose D, Pang W, Walker R, Patil V, Weich N and Hoffman R. Characterization of primitive marrow CD34+ cells that persist after a sublethal dose of total body irradiation. Exp. Hematol. 33:1388-401, 2005.

5. Araki H, Mahmud N, Milhem M, Nunez R, Xu M, Beam CA and Hoffman R. Expansion of human cord blood SCID-repopulating cells using chromatin modifying agents. Exp. Hematol. 34:140-9, 2006.

6. Araki H, Yoshinaga K, Boccuni P, Zhao Y, Hoffman R and Mahmud N. Chromatin modifying agents permit human hematopoietic stem cells to undergo multiple cell divisions while retaining their repopulating potential. Blood. 109:3570-3578, 2007.

7. Araki H, Baluchamy S, Yoshinaga K, Petro B, Petiwala S, Parajuli R, Milhem M, Lavelle D, DeSimone J and Mahmud N. Cord blood stem cell expansion is permissive to epigenetic regulation and environmental cues. Exp. Hematol. 37:1084-1095, 2009.

8. Araki H, Chute JP, Petro B, Halliday L, Hoffman R and Mahmud N. Bone marrow CD34+ cells expanded on human brain endothelial cells reconstitute lethally irradiated baboons in a variable manner. Leuk. Lymphoma. 51 (6):1121-1127, 2010.

9. Mahmud D, Nicolini B, van den Dries L, Mahmud N, Arpinati M and Rondelli D. Human CD4(+)CD25(+) Cells in Combination with CD34(+) Cells and Thymoglobulin to Prevent Anti-hematopoietic Stem Cell T Cell Alloreactivity. Biol. Blood Marrow Transplant. 17(1):61-8, 2011.

10. Lavelle D, Vaitkus K, Ruiz MA, Ibanez V, Kouznetsova T, Saunthararajah Y, Mahmud N and DeSimone J. Effect of AGM and fetal liver-derived stromal cell lines on globin expression in adult baboon (P. anubis) bone marrow-derived erythroid progenitors. PLoS. One. 7(5):e36846, 2012.

11. Patel P, Abbasian J, Mahmud D, Mahmud N, Horsthemke PM, Chunduri S, Rondelli D. Allostimulatory activity of CD133+ hematopoietic cells. Bone Marrow Transplant. 2012


Book Chapters

1. Koury MJ, Mahmud N and Rhodes MM. Origin and Development of Blood Cells. In: “Wintrobe’s Clinical Hematology”, edited by JP Greer. Lippincott Williams & Wilkins, Pittsburg, PA: 2009.  

2. Szilagyi E, Mahmud N and Bartholomew A. The importance of non-human primate models for pre-clinical studies in hematopoiesis. In: “Allogeneic Stem Cell Transplantation”, edited by HM Lazarus and MJ Laughlin. Springer Sicence+Buisness Media, New York, NY, 2009.


Invention/Patent

1. Inventors: Mahmud N. Methods for in vitro expansion of hematopoietic stem cells. Patent No.: US PATENT 7927785; Date of Patent: May 2011.

2. Inventors: Mahmud N. Methods of ex vivo expansion of blood progenitor cells and generation of composite grafts. Patent No.: pending; Date of Patent: filed November 2012.