RESEARCH
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Patricia W. Finn, MD. Department Chair

© Copyright 2014 The Board of Trustees of the University of Illinois

Pradeep K. Dudeja, Ph.D.


Academic Title: Professor of Physiology in Medicine

Administrative Positions: Director, Intestinal Transport Group, UIC & JBVAMC; Director of Research, Division of Gastroenterology and Hepatology

Division: Gastroenterology and Hepatology

Location: 820 S. Damen Ave., JBVAMC, MP 151, Chicago, IL 60612

Phone: (312)569-7434 (Office) Fax: (312)569-6487

E-mail: pkdudeja@uic.edu



Education:

PhD, Postgraduate Institute of Medical Education and Research, Chandigarh, India (1983)


Faculty Positions:


Clinical Specialties


Research Interests  


Selected Publications

  1. Saksena S, Tyagi S, Goyal S, Gill RK, Alrefai WA, Ramaswamy K and Dudeja PK.  Stimulation of apical Cl-/OH- exchanger, SLC26A3 by neuropeptide Y (NPY) is lipid raft dependent.  Am. J. Physiol. 299(6):G1334-43, 2010.
  2. Bhattacharyya S, Dudeja PK and Tobacman JK. Tumor necrosis factor-α-induced inflammation is increased and apoptosis is inhibited by Common food additive carrageenan. J. Biol. Chem. 285(50):39511-22, 2010.
  3. Liu H, Singla A, Ao M, Gill RK, Venkatasubranian J, Rao MC, Alrefai WA and Dudeja PK. Calcitonin receptor (CTR)-mediated CFTR activation in human intestinal epithelial cells (IECs).  J. Cell Mol. Med. 15(12):2697-705, 2011.
  4. Saksena S, Goyal S, Raheja G, Singh V, Akhtar M, Nazir TM, Alrefai WA, Gill RK and Dudeja PK. Upregulation of P-glycoprotein by Probiotics in Intestinal Epithelial Cells and in the Dextran Sulfate Sodium Model of Colitis in Mice. Am. J. Physiol. Gastrointest. Liver Physiol. 300(6):G1115-23, 2011.
  5. Kumar P, Malhotra P, Ma K, Singla A, Hedroug O, Saksena S, Dudeja PK, Gill RK, Alrefai WA. SREBP2 mediates the modulation of Intestinal NPC1L1 Expression by Curcumin. Am. J. Physiol. Gastrointest. Liver Physiol. 301(1):G148-55, 2011.
  6. Malakooti J, Saksena S, Gill RK and Dudeja PK. Transcriptional regulation of the intestinal luminal sodium and chloride transporters. Biochem. J. 435, 313–325, 2011.
  7. Bhattacharyya S, Borthakur A, Anbazhagan AN, Dudeja PK and Tobacman JK. Specific effects of BCL10 Serine mutations on phosphorylations in canonical and noncanonical pathways of NF-κB activation following carrageenan. Am. J. Physiol. Gastrointest. Liver Physiol. 301(3):G475-86, 2011.
  8. Muthusamy S, Shukla S, Amin MR, Cheng M, Orenuga T, Dudeja PK and Malakooti J. PKCδ-dependent activation of ERK1/2 leads to upregulation of the human NHE2 transcriptional activity in intestinal epithelial cell line C2BBe1. Am. J. Physiol. Gastrointest. Liver Physiol. 302(3):G317-25, 2011.
  9. Xiao F, Juric M, Li J, Riederer B, Yeruva S, Kumar Singh A, Zheng L, Glage S, Kollias G, Dudeja PK, Tian DA, Xu G, Zhu J, Bachmann O and Seidler U. Loss of downregulated in adenoma (DRA) impairs mucosal HCO(3) (-) secretion in murine ileocolonic inflammation. Inflamm. Bowel Dis. 18(1):101-11, 2012.
  10. Singla A, Kumar A, Priyamvada S, Tahniyath M, Saksena S, Gill RK, Alrefai WA and Dudeja PK. LPA Stimulates Intestinal DRA Gene Transcription via LPA2 Receptor, PI3K/AKT and c-fos Dependent Pathway. Am. J. Physiol. Gastrointest. Liver Physiol. 302(6):G618-27, 2012.
  11. Annaba F, Kumar P, Sarwar Z, Gill RK, Viswanathan VK, Saksena S, Hecht GA, Dudeja PK and Alrefai WA.  Enteropathogenic E.coli (EPEC) infection inhibits ileal bile acid transporter ASBT. Am. J. Physiol. 302(10):G1216-22, 2012.
  12. Borthakur A, Bhattacharyya S, Anbazhagan AN, Kumar A, Dudeja PK and Tobacman JK. Prolongation of carrageenan-induced inflammation in human colonic epithelial cells by activation of an NFκB-BCL10 loop. Biochem. Biophys. Acta. 1822(8):1300-7, 2012.
  13. Borthakur A, Priyamvada S, Kumar A, Natarajan AA, Gill RK, Alrefai WA and Dudeja PK. A Novel Nutrient Sensing Mechanism Underlies Substrate-induced Regulation of Monocarboxylate Transporter 1. Am. J. Physiol. Gastrointest. Liver Physiol. 303(10):G1126-33, 2012.
  14. Singh V, Raheja G, Borthakur A, Kumar A, Gill RK, Alakkam A, Malakooti J and Dudeja PK. Lactobacillus acidophilus Upregulates Intestinal NHE3 Expression and Function. Am. J. Physiol. Gastrointest. Liver Physiol. 303(12):G1393-401, 2012.
  15.  Malhotra P, Boddy CS, Soni V, Saksena S, Dudeja PK, Gill RK and Alrefai WA. D-Glucose Modulates Intestinal Niemann-Pick C1 Like 1 (NPC1L1) Gene Expression via Transcriptional Regulation. Am. J. Physiol. Gastrointest. Liver Physiol. 304(2):G203-10, 2012.
  16. Gill RK, Kumar A, Malhotra P, Maher D, Singh V, Dudeja P, Alrefai WA and Saksena S. Regulation of intestinal serotonin transporter (SERT) expression via epigenetic mechanisms: Role of HDAC2. Am. J. Physiol. Gastrointest. Liver Physiol. 304(4):C334-41, 2012.
  17. Saksena S, Priyamvada S, Kumar A, Akhtar M, Soni V, Anbazhagan AN, Alakkam A, Alrefai WA, Dudeja PK and Gill RK. Keratinocyte Growth Factor-2 Stimulates P-glycoprotein Expression and Function in Intestinal Epithelial Cells. Am. J. Physiol. Gastrointest. Liver Physiol. 304(6):G615-22, 2013.
  18. Sanchez-Tena S,  Vizan P,  Dudeja P and Centelles J. Green tea polyphenols inhibit butyrate-induced differentiation of colon cancer cells by interacting with Monocarboxylate Transporter 1 (MCT1). J. Biol. Chem. (submitted).