RESEARCH
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Patricia W. Finn, MD. Department Chair

© Copyright 2014 The Board of Trustees of the University of Illinois

Rhonda D. Kineman, Ph.D.


Academic Title: Associate Professor of Medicine

Administrative Positions:

Division: Endocrinology, Diabetes and Metabolism

Location: 820 S. Damen Ave., Suite 6215, Chicago, IL 60612

Phone: (312)569-6977 (Office), 569-7417(Lab) Fax: (312)569-8114

E-mail: kineman@uic.edu



Education:

PhD, University of Georgia, Athens, GA (1988)

Postdoctoral Fellow, Medical University of South Carolina, Charleston, SC (1988-1994)


Faculty Positions:


Clinical Interests


Research Interests


Selected Publications

  1. Park S, Sohn S, Kineman RD. Fasting-induced changes in the hypothalamic-pituitary-GH axis in the absence of GH expression: lessons from the spontaneous dwarf rat. J. Endocrinol. 180(3):369-78, 2004.
  2. Kamegai J, Tamura H, Shimizu T, Ishii S, Tatsuguchi A, Sugihara H, Oikawa S and Kineman RD. The role of pituitary ghrelin in growth hormone (GH) secretion: GH-releasing hormone-dependent regulation of pituitary ghrelin gene expression and peptide content. Endocrinology. 145(8):3731-8, 2004.
  3. Park S, Peng XD, Frohman LA and Kineman RD. Expression analysis of hypothalamic and pituitary components of the growth hormone axis in fasted and streptozotocin-treated neuropeptide Y (NPY)-intact (NPY+/+) and NPY-knockout (NPY-/-) mice. Neuroendocrinology. 81(6):360-71, 2005.
  4. Luque RM and Kineman RD. Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function. Endocrinology. 147(6):2754-63, 2006.
  5. Luque RM, Gahete MD, Hochgeschwender U, Kineman RD. Evidence that endogenous SST inhibits ACTH and ghrelin expression by independent pathways. Am. J. Physiol. Endocrinol. Metab. 291(2):E395-403, 2006.
  6. Luque RM, Huang ZH, Shah B, Mazzone T, Kineman RD. Effects of leptin replacement on hypothalamic-pituitary growth hormone axis function and circulating ghrelin levels in ob/ob mice. Am. J. Physiol. Endocrinol. Metab. 292(3):E891-9, 2007.
  7. Luque RM and Kineman RD. Gender-dependent role of endogenous somatostatin in regulating growth hormone-axis function in mice. Endocrinology. 148(12):5998-6006, 2007.
  8. Taboada GF, Luque RM, Neto LV, Machado Ede O, Sbaffi BC, Domingues RC, Marcondes JB, Chimelli LM, Fontes R, Niemeyer P, de Carvalho DP, Kineman RD and Gadelha MR. Quantitative analysis of somatostatin receptor subtypes (1-5) gene expression levels in somatotropinomas and correlation to in vivo hormonal and tumor volume responses to treatment with octreotide LAR. Eur. J. Endocrinol. 158(3):295-303, 2008.
  9. Luque RM, Soares BS, Peng XD, Krishnan S, Cordoba-Chacon J, Frohman LA and Kineman RD. Use of the metallothionein promoter-human growth hormone-releasing hormone (GHRH) mouse to identify regulatory pathways that suppress pituitary somatotrope hyperplasia and adenoma formation due to GHRH-receptor hyperactivation. Endocrinology. 150(7):3177-85, 2009.
  10. Childs GV, Akhter N, Haney A, Syed M, Odle A, Cozart M, Brodrick Z, Gaddy D, Suva LJ, Akel N, Crane C, Benes H, Charlesworth A, Luque R, Chua S and Kineman RD. The somatotrope as a metabolic sensor: deletion of leptin receptors causes obesity. Endocrinology. 152(1):69-81, 2011.
  11. Luque RM, Córdoba-Chacón J, Gahete MD, Navarro VM, Tena-Sempere M, Kineman RD and Castaño JP. Kisspeptin regulates gonadotroph and somatotroph function in nonhuman primate pituitary via common and distinct signaling mechanisms. Endocrinology. 152(3):957-66, 2011.
  12. Luque RM, Lin Q, Córdoba-Chacón J, Subbaiah PV, Buch T, Waisman A, Vankelecom H and Kineman RD. Metabolic impact of adult-onset, isolated, growth hormone deficiency (AOiGHD) due to destruction of pituitary somatotropes. PLoS One. 6(1):e15767, 2011.
  13. Gahete MD, Córdoba-Chacón J, Anadumaka CV, Lin Q, Brüning JC, Kahn CR, Luque RM and Kineman RD. Elevated GH/IGF-I, due to somatotrope-specific loss of both IGF-I and insulin receptors, alters glucose homeostasis and insulin sensitivity in a diet-dependent manner. Endocrinology. 152(12):4825-37, 2011.
  14. Córdoba-Chacón J, Gahete MD, Castaño JP, Kineman RD and Luque RM. Homologous and heterologous in vitro regulation of pituitary receptors for somatostatin, growth hormone (GH)-releasing hormone, and ghrelin in a nonhuman primate (Papio anubis). Endocrinology. 153(1):264-72, 2012.
  15. Córdoba-Chacón J, Gahete MD, Culler MD, Castaño JP, Kineman RD and Luque RM. Somatostatin dramatically stimulates growth hormone release from primate somatotrophs acting at low doses via somatostatin receptor 5 and cyclic AMP. J. Neuroendocrinol. 24(3):453-63, 2012.
  16. Cordoba-Chacon J, Gahete MD, Pozo-Salas AI, Moreno-Herrera A, Castaño JP, Kineman RD and Luque RM. Peripubertal-onset but not adult-onset obesity increases IGF-I and drives development of lean mass, which may lessen the metabolic impairment in adult obesity. Am. J. Physiol. Endocrinol. Metab. 303(9):E1151-7, 2012.
  17. Gahete MD, Córdoba-Chacón J, Luque RM and Kineman RD. The rise in growth hormone during starvation does not serve to maintain glucose levels or lean mass but is required for appropriate adipose tissue response in female mice. Endocrinology. 154(1):263-9, 2013.
  18. Lubbers ER, List EO, Jara A, Sackman-Sala L, Cordoba-Chacon J, Gahete MD, Kineman RD, Boparai R, Bartke A, Kopchick JJ and Berryman DE. Adiponectin in mice with altered GH action: links to insulin sensitivity and longevity? J. Endocrinol. 216(3):363-74, 2013.