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University of Illinois College of Medicine at Chicago >> Education, Departments & Programs >> Departments >> Research >> Steven M Dudek MD

Steven M. Dudek, M.D.

Academic Title: Associate Professor of Medicine

Administrative Positions: Co-Director, Medical Intensive Care Unit

Division: Pulmonary, Critical Care, Sleep and Allergy Medicine

Location: 909 S. Wolcott Ave., COMRB 3143 (MC 719), Chicago, IL 60612

Phone: (312)355-5587 (Office) Fax: (312)996-7193



MD, Washington University, St. Louis, MO (1995)

Intern, Johns Hopkins Hospital, Baltimore, MD (1995-1996)

Resident, Johns Hopkins Hospital, Internal Medicine, Baltimore, MD (1996-1998)

Fellow, Johns Hopkins Hospital, Baltimore, MD (1998-2002)

Faculty Positions:

Clinical Specialties

Research Interests

Selected Publications

  1. Usatyuk PV, Romer LH, He D, Parinandi NL, Kleinberg ME, Zhan S, Jacobson JR, Dudek SM, Pendyala S, Garcia JG and Natarajan V. Regulation of hyperoxia-induced NADPH oxidase activation in human lung endothelial cells by the actin cytoskeleton and cortactin. J. Biol. Chem. 282(32):23284-95, 2007.
  2. Wang L and Dudek SM. Regulation of vascular permeability by sphingosine 1-phosphate. Microvasc. Res. 77(1):39-45, 2009.
  3. Camp SM, Bittman R, Chiang ET, Moreno-Vinasco L, Mirzapoiazova T, Sammani S, Lu X, Sun C, Harbeck M, Roe M, Natarajan V, Garcia JG and Dudek SM. Synthetic analogs of FTY720 [2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol] differentially regulate pulmonary vascular permeability in vivo and in vitro. J. Pharmacol. Exp. Ther. 331(1):54-64, 2009.
  4. Brown M, Adyshev D, Bindokas V, Moitra J, Garcia JG and Dudek SM. Quantitative distribution and colocalization of non-muscle myosin light chain kinase isoforms and cortactin in human lung endothelium. Microvasc. Res. 80(1):75-88, 2010.
  5. Dudek SM, Chiang ET, Camp SM, Guo Y, Zhao J, Brown ME, Singleton PA, Wang L, Desai A, Arce FT, Lal R, Van Eyk JE, Imam SZ and Garcia JG. Abl tyrosine kinase phosphorylates nonmuscle Myosin light chain kinase to regulate endothelial barrier function. Mol. Biol. Cell. 21(22):4042-56, 2010.
  6. Mirzapoiazova T, Moitra J, Moreno-Vinasco L, Sammani S, Turner JR, Chiang ET, Evenoski C, Wang T, Singleton PA, Huang Y, Lussier YA, Watterson DM, Dudek SM and Garcia JG. Non-muscle myosin light chain kinase isoform is a viable molecular target in acute inflammatory lung injury. Am. J. Respir. Cell. Mol. Biol. 44(1):40-52, 2011.
  7. Dudek SM, Muñoz NM, Desai A, Osan CM, Meliton AY and Leff AR. Group V phospholipase A2 mediates barrier disruption of human pulmonary endothelial cells caused by LPS in vitro. Am. J. Respir. Cell. Mol. Biol. 44(3):361-8, 2011.
  8. Wang L, Chiang ET, Simmons JT, Garcia JG and Dudek SM. FTY720-induced human pulmonary endothelial barrier enhancement is mediated by c-Abl. Eur. Respir. J. 38(1):78-88, 2011.
  9. Adyshev DM, Moldobaeva NK, Elangovan VR, Garcia JG and Dudek SM. Differential involvement of ezrin/radixin/moesin proteins in sphingosine 1-phosphate-induced human pulmonary endothelial cell barrier enhancement. Cell Signal. 23(12):2086-96, 2011.
  10. Belvitch P and Dudek SM. Role of FAK in S1P-regulated endothelial permeability. Microvasc. Res. 83(1):22-30, 2012.