RESEARCH
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Patricia W. Finn, MD. Department Chair

© Copyright 2014 The Board of Trustees of the University of Illinois

Shiva Shahrara, Ph.D.


Academic Title: Associate Professor of Medicine

Administrative Positions:

Division: Rheumatology

Location: 835 S. Wolcott Ave., Room E807, Chicago, IL 60612

Phone: (312)413-7529 (Office), 413-8781 (Lab) Fax: (312)413-9271

E-mail: shahrara@uic.edu





Education:

PhD, Karolinska Institute, Stockholm, Sweden (1999)

Postdoctoral Fellow, Northwestern University, Chicago, Illinois (2000-2003)


Faculty Positions:


Clinical Specialties


Research Interests


Selected Publications

  1. Shahrara S, Proudfoot AE, Park CC, Volin MV, Haines GK, Woods JM, Aikens CH, Handel TM and Pope RM. Inhibition of monocyte chemoattractant protein-1 ameliorates rat adjuvant-induced arthritis. J. Immunol. 180(5):3447-56, 2008.
  2. Shahrara S, Pickens SR, Dorfleutner A and Pope RM. IL-17 induces monocyte migration in rheumatoid arthritis J. Immunol. 182(6):3884-91, 2009.
  3. Pickens SR, Volin MV, Mandelin AM, Kolls JK, Pope RM and Shahrara S. IL-17 contributes to angiogenesis in rheumatoid arthritis. J. Immunol. 184(6):3233-41, 2010.
  4. Pickens SR, Chamberlain ND, Volin MV, Pope RM, Mandelin AM and Shahrara S. Characterization of CCL19 and CCL21 in rheumatoid arthritis. Arthritis Rheum. 63(4):914-22, 2011.
  5. Pickens SR, Chamberlain ND, Volin MV, Mandelin AM, Agrawal H, Matsui M, Yoshimoto T and Shahrara S. Local expression of interleukin-27 ameliorates collagen-induced arthritis. Arthritis Rheum. 63(8):2289-98, 2011.
  6. Pickens SR, Chamberlain ND, Volin MV, Pope RM, Talarico NE, Mandelin AM and Shahrara S. Characterization of interleukin-7 and interleukin-7 receptor in the pathogenesis of rheumatoid arthritis. Arthritis Rheum. 63(10):2884-93, 2011.
  7. Volin MV and Shahrara S. Role of TH-17 cells in rheumatic and other autoimmune diseases. Rheumatology (Sunnyvale). 1(104), 2011.
  8. Pickens SR, Chamberlain ND, Volin MV, Gonzalez M, Pope RM, Mandelin AM, Kolls JK and Shahrara S. Anti-CXCL5 therapy ameliorates IL-17-induced arthritis by decreasing joint vascularization. Angiogenesis. 14(4):443-55, 2011.
  9. Chamberlain ND, Vila OM, Volin MV, Volkov S, Pope RM, Swedler W, Mandelin AM and Shahrara S. TLR5, a novel and unidentified inflammatory mediator in rheumatoid arthritis that correlates with disease activity score and joint TNF-α  levels. J. Immunol 189(1):475-83, 2012.
  10. Pickens SR, Chamberlain ND, Volin MV, Pope RM, Talarico NE, Mandelin AM and Shahrara S. Role of the CCL21 and CCR7 pathways in rheumatoid arthritis angiogenesis. Arthritis Rheum. 64(8):2471-81, 2012.
  11. Chamberlain ND, Kim SJ, Vila OM, Volin MV, Volkov S, Pope RM, Arami S, Mandelin AM and Shahrara S. Ligation of TLR7 by rheumatoid arthritis synovial fluid single strand RNA induces transcription of TNFα in monocytes. Ann. Rheum. Dis. 72(3):418-26, 2013.
  12. Pope RM and Shahrara S. Possible roles of IL-12-family cytokines in rheumatoid arthritis. Nat. Rev. Rheumatol. 9(4):252-6, 2013.
  13. Chen Z, Kim SJ, Chamberlain ND, Pickens SR, Volin MV, Volkov S, Arami S, Christman JW, Prabhakar BS, Swedler W, Mehta A, Sweiss N and Shahrara S. The Novel Role of IL-7 Ligation to IL-7 Receptor in Myeloid Cells of Rheumatoid Arthritis and Collagen-Induced Arthritis. J. Immunol. 190(10):5256-66, 2013.