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University of Illinois College of Medicine at Chicago >> Education, Departments & Programs >> Departments >> Research >> Tohru Fukai MD PhD

Tohru Fukai, M.D., Ph.D.


Academic Title: Associate Professor of Medicine and Pharmacology

Administrative Positions:

Division: Cardiology

Location: 835 S. Wolcott Ave., COMRB 4080 (MC 868), Chicago, IL 60612

Phone: (312)996-7631 (Office), 996-7622 (Lab) Fax: (312)996-1225

E-mail: tfukai@uic.edu


Education:

MD, Kyushu University, Japan (1988)

PhD, Kyushu University, Japan (1995)

Resident, Kyushu University, Japan (1988-1991)

Fellow, Kyushu University, Japan (1990-1993)

Postdoctoral Fellow, Emory University, Atlanta, GA (1995-1999)


Faculty Positions:


Clinical Interests


Research Interests


Selected Publications

  1. Nguyen AD, Itoh S, Jeney V, Yanagisawa H, Fujimoto M, Ushio-Fukai M and Fukai T. Fibulin-5 is a novel binding protein for extracellular superoxide dismutase. Circ. Res. 95:1067-74, 2004.
  1. Jeney V, Itoh S, Wendt M, Gradek Q, Ushio-Fukai M, Harrison DG and Fukai T. The Role of Antioxidant-1 in Extracellular Superoxide Dismutase Function. Circ. Res. 96:723-9, 2005.
  2. Qin Z, Itoh S, Jeney V, Ushio-Fukai M and Fukai T. Essential Role for the Menkes ATPase in Activation of Extracellular Superoxide Dismutase: Implication for Vascular Oxidative Stress. FASEB J. 20:334-6, 2006.
  1. Gongora MC, Qin Z, Laude K, Kim HW, McCann L, Dikalov S, Folz RJ, Fukai T and Harrison DG. The Role of Extracellular Superoxide Dismutase in Hypertension.  Hypertension.  48:473-81, 2006.
  1. Kim H, Lin A, Guldberg R, Ushio-Fukai M and Fukai T. Essential role of extracellular superoxide dismutase in neovascularization in response to hindlimb ischemia. Circ. Res. 101:409-19, 2007.
  2. Qin Z, Gongora MC, Ozumi K, Itoh S, Akram K, Ushio-Fukai M, Harrison DG and Fukai T. Role of Menkes ATPase in Angiotensin II-induced Hypertension: A Key Modulator for Extracellular SOD.  Hypertension. 52:945-51, 2008.
  3. Finney L, Vogt S, Fukai T and Glesne D. Copper and Angiogenesis: unraveling a relationship key to cancer progression (invited review). Clin. Exp. Pharmacol. Physiol. 36:88-94, 2009.
  1. Itoh S, Kim HW, Nakagawa O, Lessner SM, Akram K, Ushio-Fukai M and Fukai T. Novel role of antioxidant-1 (Atox1) as a copper-dependent transcription factor involved in cell proliferation. J. Biol. Chem. 283:9157-67, 2008.
  1. Gongora MC, Lob HE, Landmesser U, Guzik T, Martin WD, McCann L, Gamez G, Wall SM, Cocuracou I, Sorescou D, Wilson DS, Murthey N, Gravannis M, Fukai T and Harrison DG. The Extracellular Superoxide Dismutase is Essential for Survival in Ambient Oxygen. Am. J. Pathol. 173:915-26, 2008.
  2. Itoh S, Ozumi K, Kim HW, Nakagawa O, Folz RJ, Zelko IN, Ushio-Fukai M and Fukai T. Novel Mechanism for Regulation of Extracellular SOD Transcription and Activity by Copper: Role of Antioxidant-1. Free Radic. Biol. Med. 46:95-104, 2009.
  3. Oshikawa J, Urao N, Kim HW, Kaplan N, Razvi M, McKinney R, Poole LB, Fukai T and Ushio-Fukai M. Extracellular SOD-derived H2O2 promotes VEGF signaling in caveolae/lipid rafts and post-ischemic angiogenesis in mice. PLoS One. 5:e10189, 2010.
  4. Schneider MP, Sullivan JC, Wach PF, Boesen EI, Yamamoto T, Fukai T, Harrison DG, Pollock DM and Pollock JS. Protective role of extracellular superoxide dismutase in renal ischemia/reperfusion injury. Kidney Int. 78:374-381, 2010.
  5. Wedgwood S, Lakshminrusimha S, Fukai T, Russell JA, Schumacker PT and Steinhorn RH. Hydrogen peroxide regulates extracellular superoxide dismutase activity and expression in neonatal pulmonary hypertension. Antioxid. Redox Signal. 15:1497-1506, 2011.  
  1. Ashino T, Varadarajan S, Urao N, Oshikawa J, Chen GF, Wang H, Huo Y, Finney LA, Vogt S, McKinney R, Maryon, EB, Kaplan JH, Ushio-Fukai M and Fukai T. Unexpected Role of the Copper Transporter ATP7A in PDGF-Induced Vascular Smooth Muscle Cell Migration. Circ. Res. 107:787-799, 2010.
  2. Fukai T and Ushio-Fukai M. Superoxide Dismutases: Role in Redox Signaling, Vascular Function and Diseases. Antioxid. Redox Signal. 15:1583-606, 2011.