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University of Illinois College of Medicine at Chicago >> Education, Departments & Programs >> Departments >> Research >> Yves A Lussier MD

Yves A. Lussier, M.D.

Academic Title: Professor of Medicine and Bioengineering

Administrative Positions: Assistant Vice President for Health Affairs and Clinical Research Information Officer, University of Illinois Hospital and Health Science System

Division: General Internal Medicine

Location: 909 S. Wolcott Ave., COMRB 8095 (MC 789), Chicago, IL 60612

Phone: (312)355-0478 (Office), 413-5673 Fax: (312)996-5413



MD, University of Sherbrooke, PQ, Canada (1989)

Intern, Centre Hospitalier Universitaire, Quebec, Canada (1989-1990)

Resident, Centre Hospitalier Universitaire, Quebec, Canada (1990-1992)

Postdoctoral Fellow, Columbia University, New York, NY (1998-2001)

Faculty Positions:

Clinical Specialties

Research Interests

Selected Publications

  1. Lee Y, Yang X, Huang Y, Fan H, Zhang Q, Wu Y, Li J, Hasina R, Cheng C, Lingen MW, Gerstein MB, Weichselbaum RR, Xing HR and Lussier YA. Network modeling identifies molecular functions targeted by miR-204 to suppress head and neck tumor metastasis. PLoS. Comput. Biol. 6(4):e1000730, 2010.  
  2. Chen J, Li J, Huang Y, Stadler W and Lussier YA. Protein-Network Modeling of Prostate Cancer Gene Signatures Reveals Essential Pathways in Disease Recurrence. J. Am. Med. Inform. Assoc. 18:392-402, 2011.
  3. Lussier YA and Chen JL. The Emergence of Genome-Based Drug Repositioning. Sci. Transl. Med. 3(96):96ps35, 2011.
  4. Li H, Lee Y, Li J, Chen JL, Rebman E and Lussier YA. Complex Disease Networks of Trait-Associated SNPs Unveiled by Information Theory.  J. Am. Med. Inform. Assoc. 19:295-305, 2012.
  5. Regan K , Wang K, Doughty E, Li H, Li J, Lee Y, Kann M and Lussier YA. Mechanistic Concordance between Mendelian and Complex Inheritance of Alzheimer’s Genes for Predicting Unique Personal Genome Variants. J. Am. Med. Inform. Assoc.19:306-316, 2012.
  6. Yang X, Huang Y, Li J, Seiwert TY, Cohen EEW, HR Xing and Lussier YA. Single Sample Expression-Anchored Profiles of Oncogenic Mechanisms Predict Survival in Head and Neck Cancer. PLoS Comput. Biol. 8(1): e1002350, 2012.
  7. Lussier YA, Xing HR, Salama JK, Khodarev NN, Huang Y, Zhang Q, Khan SA, Yang X, Hasselle MD, Darga TE, Malik R, Fan H, Perakis S, Filippo M, Corbin K, Lee Y, Posner MC, Chmura SJ, Hellman S and Weichselbaum RR. MicroRNA expression characterizes oligometastasis(es). PLoS ONE.  6(12): e28650, 2012.
  8. Lussier YA, Regan K, Khodarev NN, Corbin K, Li H, Khan SA, Ganai S, Gnerlich J, Darga TE, Fan H, Huang Y, Karpenko O, Posner MC, Chmura SJ, Hellman S, Ferguson MK and Weichselbaum RR. MicroRNAs of oligometastasis(es) progression predict survival better than initial metastatic presentation. PLoS ONE. In press; 2012.
  9. Lee Y, Gamazon ER, Rebman E, Yeunsook Lee, Lee S, Dolan ME, Cox NJ and Lussier YA. Variants Affecting Exon Skipping Contribute to Complex Traits. PLoS Genetics 8(10):e1002998, 2012.
  10. Perez-Rathke A, Li H and Lussier YA. Interpreting Personal Transcriptomes: Personalized Mechanism-scale profiling of RNA-Seq Data. Pac. Symp. Biocomput. 18:159-17, 2013.
  11. Boyd A, Burton MD, Li J, Jonen M, Bahroos N, Brown SB, Vanden Hoek T and Lussier YA. The discriminatory cost of ICD-10-CM transition between clinical specialties: metrics, case study and mitigating tools. J. Am. Med. Inform. Assoc. Epub ahead of print, 2013.