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University of Illinois College of Medicine at Chicago >> Education, Departments & Programs >> Departments >> Medicine >> Research


In the United States, 2.5 million people have rheumatoid arthritis (RA). RA is a chronic inflammatory autoimmune disorder that starts in the young to middle adult years and may lead to complete joint destruction.

There is no cure for RA at present and a substantial percentage of patients do not respond to current therapy, therefore novel therapeutic approaches are urgently needed. To address this important issue, my laboratory focuses on identifying new targets and/or biomarkers for RA disease severity and response to effective therapy.

To identify these novel targets or biomarkers for RA severity, we performed microarray studies in order to determine differentially regulated genes in macrophages obtained from synovial fluid of RA patients with active disease compared to normal macrophages and have found a number of important targets.

We next examine the mechanism by which these factors mediate RA pathology initially utilizing RA peripheral blood, synovial tissue and synovial fluid and we subsequently determine whether blockade of this these factors could ameliorate the experimental arthritis model through the same underlying pathways identified in RA specimens….. More >>

About Us

In 2012, the University of Illinois at Chicago ranked 47 in NIH funding granted to medical schools. The Department of Medicine, with its 226 faculty members, obtains external research funding from the National Institutes of Health (NIH), private foundations (e.g., American Heart Association, National Kidney Foundation), clinical trials, and industry. The department currently has over 35 Research Project Grants (R01), 5 Research Program Project Grants (P01), and 4 Institutional Training Grants (T32) totaling over $30 million. Research in the Department of Medicine occupies over 30,000 sq. ft. in six buildings on the West Campus.

Scholarly Activity in DOM

Basic research in the Department of Medicine involves discovery-based research on the normal functions of systems, organs, tissues, cells, and molecules, as well as disease-related research, which derives its primary rationale from diseases and includes research on disease mechanisms. The Department of Medicine also has a strong translational research component, in which researchers apply discoveries generated during research in the laboratory and in preclinical studies to the development of trials and studies in humans. Comparative effectiveness of prevention and treatment strategies are also and important part of translational research in the Department of Medicine. Clinical research in the Department of Medicine includes patient-oriented research such as clinical trials and studies to develop new technology related to disease, epidemiologic and behavioral studies, as well as outcomes and health services research.

The Department of Medicine has an immense collaborative community, allowing researchers to cross into different disciplines to answer important questions. Our research teams work to ensure that tomorrow's science is practiced as today’s medicine.

Mission Statement and Overall Goals

The Department of Medicine at the University of Illinois at Chicago is committed to advancing knowledge and translating discoveries at the bench into clinical practice. Faculty members in each of our eleven divisions are dedicated to basic and translational research which focuses on latest innovations in a variety of diseases and health care services. Additionally, we have 5 Organized Research Units which focus on specific areas of interest and include faculty members from several divisions.