Directory
Adjunct Faculty
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| pknepper@uic.edu | |
| Phone | 312-413-3942 |
| Fax | 312-996-7770 |
| Office | LB-109 |
| Mailing Address | 150 E. Huron, Suite 1000, Chicago, IL 60611 |
Research Interests
Glaucoma and Neurodegenerative Diseases
Clinical Interests
Glaucoma, strabismus
Current grants or clinical trials
On the cause and prevention of Glaucoma, Alcon Laboratories Ltd
| 1964 | BA: Northwestern University, History and Literature of Religion |
| 1968 | MD: Northwestern University Medical School |
| 1978 | FAOO: Fellow of American Academy of Ophthalmology and Otolaryngology |
| 1980 | PhD: Northwestern University, Anatomy and Cell Biology |
| 1968-1969 | Internship: Straight Medical, Cook County Hospital, Chicago, IL |
| Jul 1970 - Jun 1973 | Residency Training: Ophthalmology, Northwestern University Medical School, Chicago, IL |
| Aug 1976 - Mar 1980 | Post-Graduate Training: Anatomy and Cell Biology, Northwestern University Graduate School, Chicago, IL |
Fellowships
| Aug 1969 - Jun 1970 | Biochemistry Fellowship, Department of Biochemistry, Northwestern University, Chicago, IL |
| Jul 1973 - Jun 1974 | Glaucoma Research Fellowship, Heed Fellow, Department of Anatomy, Northwestern University Medical School, Chicago, IL |
Honors and Awards
| 1973 - 1974 | Heed Ophthalmic Fellowship, Research on Cellular Mechanisms in Glaucoma |
| 1976 - 1980 | Award of Meritorious Service, United States Army, 1976. G.I. Bill for Postgraduate Studies |
| 1987 | Scholars Award, Research to Prevent Blindness-Olga Keith Wiess Scholars Award |
Joint Appointments
Research Scientist—Department of Ophthalmology and Visual Science, UIC
Associate Professor of Ophthalmology—Northwestern University Medical School
Representative publications
Choi J, Miller AM, Nolan NJ,Yue BYJT, Thotz ST, Clark AF, Agarwal N, and Knepper, PA: sCD44 is cytotoxic to trabecular meshwork and retinal ganglion cells in vitro. Invest Ophthalmol Vis Sci, 46:214-22, 2005.
Knepper PA, Fadel JR, Miller AM, Gossens W, Choi J, Nolan MJ, and Whitmer S: Reconstitution of trabecular meshwork GAGs: Influence of hyaluronic acid and chondroitin sulfate on flow rates. Journal of Glaucoma,14:230-238, 2005.
Knepper PA, Miller AM, Choi J, Wertz RD,Nolan MJ, Gossens W, Whitmer S, Yue
BYJT, Ritch R, Liebmann JM, Allingham RR, and Samples JR.
Hypo-phosphorylation of aqueous humor sCD44 and primary open-angle glaucoma.
Invest Ophthalmol Vis Sci,46:2829-2837, 2005.
Miller, AM, Nolan MJ, Choi J, Koga T, Shen X, Yue BYJT, and Knepper PA. Lactate treatment causes NK-êB activation and CD44 shedding in cultured trabecular meshwork cells. Invest Ophthalmol Vis Sci, 48:1615-1621, 2007.
Nolan MJ, Giovingo MC, Miller AM, Wertz RD, Ritch, R, Liebmann JM, Allingham RR, Herndon LW, Wax, MB, Smolyak R, Hasan F, Barnett EM, Samples JR, and Knepper PA. Influence of race on visual field loss and aqueous humor soluble CD44 concentration in primary open-angle glaucoma. J Glaucoma, 16:419-429, 2007.
Knepper PA, Yue BYJT. Cellular mechanisms in the trabecular meshwork affecting the aqueous outflow pathway. IN: Levin LA, Albert DM (eds): Ocular Disease: Mechanisms and Management. London UK, Elsevier , In Press.
Knepper PA, Nolan MJ, Yue BYJT. A focus on CD44 and Primary Open Angle Glaucoma. IN: Schacknow PN, Samples JR (eds): The Glaucoma Book. London UK,
Elsevier, In Press.
Knepper PA, Nolan MJ, Yue BYJT. Biomarkers of Primary Open Angle Glaucoma. IN: Schacknow PN, Samples JR (eds): The Glaucoma Book. London UK, Elsevier, In Press.