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Grand Rounds
Special Guest Lectures
Irene H. Maumenee MD
Dislocated lenses: diagnosis and management October 4, 2006, 4:00 pm
UIC West Campus
Gerald Moss Auditorium
CMRB 825 S. Wolcott, 1 st Floor
The management of dislocated lenses remains challenging because of the high risk of perioperative complications. The purpose of the presentation lies in furthering the understanding of etiologic factors to improve the management.
Lens dislocation can be caused by environmental as well as genetic factors and its natural history is commonly progressive and hence presentations are variable. Lens dislocation is seen in many connective tissue diseases: the best known is the Marfan syndrome. In the Marfan syndrome lens dislocation is not seen at birth but develops progressively and therefore dense amblyopia is not a feature. Lens dislocations results in high myopia and astigmatism, but uncomplicated surgical correction will result in excelling visual acuity. Microspherophakia lends to the most severe visual findings, but the acuity may significantly improve after total lens dislocation to the vitreous cavity. Retinal detachment and glaucoma are the blinding complications. Routine checkups and prompt installation of therapy will nowadays lead to good outcomes. The rate of detachment and glaucoma will vary by etiology of the lens dislocation.
Can these problems be prevented? A clinical trial in the Marfan syndrome will begin in January 2007 based on data observed in transgenic mice.
Details of the clinical and surgical management as well as the future of this disease group will be discussed.
Dr. Maumenee is board certified in ophthalmology and medical genetics. She is the co-founder and president of the International Society for Genetic Eye Diseases and serves as president of the Ocular Genetics Study Club. Her clinical and research interests are the nosology and management of hereditary ocular diseases, population genetics, computer application to genetic analysis, and molecular genetics.
November 16 Takayuki Akahoshi MD
November 27 Anthony Adamis MD
