Applied Physics Laboratory

Back to Mahnaz Shahidi, PhD

Research Projects

The research projects conducted in Applied Physics Laboratory generally fall into two closely connected areas, establishing innovative prototype optical imaging systems and developing digital image processing and analysis algorithms for quantitative assessment of the degree of disease-related pathologies.  These research projects help advance the state-of-the-art of optical imaging instrumentation and digital image processing techniques, providing ophthalmologists with powerful tools for more precise and accurate diagnosis of retinal diseases. 

The novel optical imaging systems under development include:

1)  a system for assessment and improvement of retinal image quality by combined optical section retinal imaging and ocular aberrations measurements in human eyes,


Optical Section Retinal Image

Shack-Hartmann Image (Top) Wavefront Abberation Function (Bottom)


2)  a system for three-dimensional imaging of the oxygen tension in the eye by measurement of phosphorescence lifetime of an oxygen-sensitive molecular probe,


Phosphorescence Optical Section Image of Oxygen-sensitive Probe


Insensity Profiles display peaks corresponding to chorioi-retinal vasculature oxygenation


3)  a system for three-dimensional optical section imaging and mapping of the topography and thickness of the retinal tissue in patients with age-related macular eye diseases.

Series of Optical Section Retinal Images & Fundus Image


Retinal Thickness Map


Vitreo- and Chorrio-retinal Topographs