Scientists

Deepak Shukla, PhD Associate Professor Director, Ocular Virology Laboratory

Research Interests

Molecular mechanisms of viral entry into human corneal cells

Study Shows How Herpes Infects Cornea, Evades Immune Cells

New research on herpes simplex virus has implications for treating ocular herpes

Education

• Postdoctoral Fellow 1996-2001 Northwestern University Department of Microbiology and Immunology Sponsor: Patricia G. Spear, PhD

• PhD 1990-1996 University of Illinois at Chicago Department of Microbiology and Immunology Advisor: Philip Matsumura, PhD

• MS 1987-1989 Banaras Hindu University, INDIA Department of Biochemistry, Biochemistry

• BS 1983-1987 Banaras Hindu University, INDIA Chemistry

UIC Appointments

2001 - present Assistant Professor Department of Ophthalmology and Visual Sciences University of Illinois at Chicago.

2001-present Assistant Professor Department of Microbiology and Immunology
University of Illinois at Chicago

Click here to visit Ocular Virology Lab Site

Recent Publications

• C. Clement, V. Tiwari, P. M. Scanlan, T. Valyi-Nagy, B. Y.J.T. Yue and D. Shukla(2006). A novel role for phagocytosis-like uptake in herpes simplex virus entry. Journal of Cell Biology 174 (7): 1009-1021.

• V. Tiwari, C. Clement, D. Xu, T. Valyi-Nagy, B. Y.J.T. Yue, J. Liu, and D. Shukla (2006) . “A Role for 3-O Sulfated Heparan Sulfate as the Receptor for Herpes Simplex Virus Type-1 Entry into Primary Human Corneal Fibroblasts”. Journal of Virology, Sep;80(18):8970-80.

• C O’Donnell, V Tiwari, M Jin-Oh, and D Shukla (2006). “A role for heparan sulfate 3-O-sulfotransferase isoform 2 in herpes simplex virus type 1 entry and spread”. Virology 346(2):452-459. (Cover Illustration).

• D Shukla , P. M. Scanlan, V Tiwari, V Sheth, C Clement, G Guzman-Hartman, TS Dermody, and T Valyi-Nagy (2006). “Expression of nectin-1 in the normal and HSV-1-infected murine nervous system”. Applied Immunohistochemistry and Molecular Morphology Sep;14(3):341-347.

• G. Guzman, S Oh, D. Shukla, and T. Valyi-Nagy (2006). “Nectin-1 expression in the normal and neoplastic human uterine cervix”. Archives of Pathology and Laboratory Medicine 130(8):1193-5.

• Guzman G, Oh SD, Shukla D, Engelhard HH, Valyi-Nagy T. (2006). “Expression of entry receptor nectin-1 of Herpes simplex virus 1 and/or Herpes simplex virus 2 in normal and neoplastic human nervous system tissues”. Acta Virologica, 50(1):59-66.

• V Tiwari , C O’Donnell, M Jin-Oh, T Valyi-Nagy, and D Shukla (2005) “A role for 3-O-sulfotransferase isoform-4 in assisting HSV-1 entry and spread”. Biochemical Biophysical Research Communications 16;338(2):930-7.

• V Tiwari, C Clement, PM Scanlan, D Kowlessur, BYJT Yue, and D Shukla. (2005) “A role for herpesvirus entry mediator as the receptor for herpes simplex virus 1 entry into primary human trabecular meshwork cells”. Journal of Virology. Oct;79(20):13173-9.

Click here to see a more extensive list of recent publications

Click here to view Dr. Shukla’s on-line CV