Campus Address
920-N CSB
840 South Wood Street (MC 719)
Chicago, Illinois 60612-7323
dwcarley@uic.edu

Clinical & Research Interests
Neuroscience of Sleep and Breathing
Sleep-Related Breathing Disorders
Animal Models of Disease, Drug Discovery, Mathematical Modeling

Professional Background
1985 - 1986
Assistant in Biomedical Engineering and Pediatrics
Massachusetts General Hospital, Boston, MA
1985 - 1986
Instructor in Pediatrics and Biomedical Engineering
Harvard Medical School, Boston, MA
1986 - 1988
Research Instructor
University of Illinois College of Medicine at Chicago
1988 - 1991
Research Assistant Professor in Medicine
University of Illinois College of Medicine at Chicago
1989 -
Executive Director of Respiratory Research
Section of Respiratory and Critical Care Medicine
University of Illinois College of Medicine at Chicago
1990 -
Director of Research
Center for Sleep and Ventilatory Disorders
University of Illinois Hospital
1991 - 2000
Research Associate Professor of Medicine
University of Illinois College of Medicine at Chicago
1993 - 2000
Research Associate Professor of Pharmacology
University of Illinois College of Medicine at Chicago
1998 - 2000
Associate Professor of Bioengineering
University of Illinois at Chicago College of Engineering
2000 -
Professor of Medicine, Bioengineering and Pharmacology
University of Illinois at Chicago

Education and Training
1978
BSEE State University of New York at Stony Brook
1982
SM Massachusetts Institute of Technology (Electrical Eng.)
1985
Ph.D. Massachusetts Institute of Technology and
Harvard University (Medical Engineering/Medical Physics)

Personal Interests and Accomplishments
Away from the office and lab, things that I enjoy include bicycling, windsurfing,
sailing and backpack camping. Happily, these are not all mutually exclusive. After
graduate school I spent a summer cycling with my camping gear around Europe.
More recently, I spent a week riding from Minneapolis to Chicago and camping along
the way. Sailing and windsurfing also go well together, and we launch a Laser and 2
sailboards from the Evanston beach. Each of these outdoor activities also provides
opportunities for amateur photography - a childhood interest that is making a
comeback for me in "the digital age".

Clinical Research
My research focuses on the neurobiology of sleep and breathing, with long-range
goals aimed at understanding the causes and consequences of sleep-disordered
breathing (e.g. sleep apnea syndrome) and developing improved diagnostic and
therapeutic options for these clinical disorders. I conduct basic animal investigations
to identify and characterize the neural networks responsible for modifying the regulation
of breathing pattern in differing sleep/wake states. These studies also aim to identify
specific derangements of the nervous system that may lead to clinical disorders such
as sleep apnea syndrome. In collaboration with Miodrag Radulovacki, Professor of
Pharmacology, I have developed an animal model of sleep-disordered breathing and am
using this model to test putative drug treatments for sleep apnea. This approach
already has led to promising findings in a proof of concept study for one drug-candidate
in 12 patients with sleep apnea. We are now conducting two additional clinical trials
with related formulations in a larger number of patients. I am also studying the
pathophysiology of sleep-disordered breathing in human studies involving healthy
control volunteers and patients with sleep apnea syndrome.

Representative Publications
Carley DW and DC Shannon. A minimal model of human periodic breathing. J Appl
Physiol 65:1400-1409, 1988.
Carley DW, E Önal, RM Aronson and M Lopata. Breath by breath interactions
between inspiratory and expiratory duration in occlusive sleep apnea. J Appl Physiol
66:2312-2319, 1989.
Carlson DM, DW Carley, E Önal, M Lopata and RC Basner. Acoustically induced
transient arousal increases pharyngeal and diaphragm muscle phasic EMG in normals.
J Appl Physiol 76:1553 - 1559, 1994.
Carley DW, SM Trbovic, A Bozanich and M Radulovacki. Cardiopulmonary control
in sleeping Sprague-Dawley rats treated with hydralazine. J Appl Physiol 83:1
954-1960, 1997.
Carley, DW and M Radulovacki. Role of peripheral serotonin in the regulation of
central sleep apneas in rats. Chest , 115:1397-1401, 1999.
Carley DW, K Berecek, A Videnovic and M Radulovacki. Sleep disordered
respiration in phenotypically normotensive, genetically hypertensive rats.
Am J Resp Crit Care Med 162: 1474-1479, 2000.
Carley, DW, S Pavlovic, M Janelidze and M Radulovacki. Functional role for
cannabinoids in respiratory stability during sleep. Sleep, 25:391-398, 2002.
Saponjic, J, M Radulovacki, DW Carley. Respiratory pattern modulation by the
pedunculopontine tegmental nucleus. Respiratory Physiology and Neurobiology,
138:223-237, 2003.
Radulovacki, M, S Pavlovic, J Saponjic and DW Carley. Modulation of reflex and
sleep related apnea by pedunculopontine tegmental and intertrigeminal neurons.
Resp Physiol Neurobiol, 143:293-306, 2004.
Saponjic, J, J Cvorovic, M Radulovacki and DW Carley. Serotonin and noradrenaline
modulate respiratory pattern disturbances evoked by glutamate injection into
pedunculopontine tegmentum of anesthetized rats. Sleep, 28:560-570, 2005.

MEDLINE LINK