Campus Address
920-N CSB
840 S. Wood Street (M/C 719)
Chicago, Illinois 60612
irubinst@uic.edu

Clinical & Research Interests
Basic Research
Nanomedicine
Targeted drug delivery
Bioimaging

Clinical
Respiratory infections
Respiratory inflammation
Lung cancer
5. Clinical Services
Pulmonary Consults
Medical Intensive Care Unit
Outpatients Clinics

Clinic Schedule
Wednesday 1-4 PM

Contact Info for Appointments
Call (312) 996-1682 - scheduling.

Professional Background
Academic and Hospital Appointments:
Nov. 1999- Medical Staff
Present Kindred Care-Lake Shore Hospital,
Chicago, Illinois

Sept. 1999- Professor of Medicine,
Present University of Illinois at Chicago,
College of Medicine, Chicago, Illinois

Sept. 1999- Professor of Biopharmaceutical Sciences (adjunct appointment),
Present University of Illinois at Chicago,
College of Pharmacy, Chicago, Illinois

Sept. 1999- Faculty, Interdisciplinary Training Program in Neuroscience,
Present University of Illinois at Chicago,
Chicago, Illinois

June 1999- Associated Professor of Pharmaceutics (adjunct appointment),
Sept. 1999 University of Illinois at Chicago,
College of Pharmacy, Chicago, Illinois

July 1998- Medical Staff
Present Tuberculosis Clinic
West Town Neighborhood Health Center
City of Chicago, Department of Health
Chicago, Illinois

Sep. 1997- Member, UIC Cancer Center
Present University of Illinois at Chicago
College of Medicine, Chicago, Illinois

Nov. 1993- Faculty Affiliate, Department of Physiology and Biophysics,
Present University of Illinois at Chicago,
Chicago, Illinois

Nov. 1993- Medical Director, Respiratory Therapy
Present VA Chicago Health Care System,
Chicago, Illinois

Nov. 1993- Staff Physician
Present VA Chicago Health Care System,
Chicago, Illinois

Oct. 1993- Attending Physician
Present University Hospital
University of Illinois at Chicago,
College of Medicine, Chicago, Illinois
Oct. 1993- Member, Graduate College
Present University of Illinois at Chicago,
Chicago, Illinois

Sept. 1993- Associate Professor of Medicine,
August 1999 University of Illinois at Chicago,
College of Medicine, Chicago, Illinois

July 1993- Associate Professor of Medicine
Aug. 1993 and Physiology, University of Nebraska
Medical Center, College of Medicine,
Omaha, Nebraska

Nov. 1990- Attending Physician,
Aug. 1993 Department of Veterans Affairs Medical
Center, Omaha, Nebraska

Sep. 1990- Attending Physician, University Hospital
Aug. 1993 University of Nebraska Medical Center,
Omaha, Nebraska

March 1990- Member, Graduate Faculty,
Aug. 1993 Graduate College, University of Nebraska,
Lincoln, Nebraska

Nov. 1989- Assistant Professor of Physiology and
June 1993 Biophysics (courtesy), University of
Nebraska Medical Center, College of
Medicine, Omaha, Nebraska

July 1989- Director, Sleep Medicine Service,
Aug. 1993 University of Nebraska Medical Center, Omaha, Nebraska

July 1989- Assistant Professor of Internal Medicine,
June 1993 University of Nebraska Medical Center,
College of Medicine, Omaha, Nebraska

1983-1985 Instructor in Internal Medicine, Sackler
School of Medicine, Tel-Aviv University,
Tel-Aviv, Israel

Education and Training
1969-1977 M.D., Hebrew University-Hadassah School of Medicine, Jerusalem, Israel

Postdoctoral training:
Internship and Residencies:
Mar. 1976- Rotating Internship, The Chaim Sheba
Feb. 1977 Medical Center, Tel-Hashomer, Israel

Oct. 1981- Resident in Medicine, The Chaim Sheba
Dec. 1984 Medical Center, Tel-Hashomer, Israel

Jan. 1985- Clinical Associate, Pulmonary Division,
June 1985 The Chaim Sheba Medical Center,
Tel-Hashomer, Israel

Fellowships:
July 1985- Fellow, Respirology, University
June 1987 of Toronto, Toronto, Ontario, Canada
July 1987- Fellow, Cardiovascular Research
June 1989 Institute, University of California,
San Francisco, California

Personal Interests and accomplishments
American history; hiking; classic music; reading

Clinical Research
Bimarkers in exhaled breath.

Representative Publications
Önyüksel H, Ikezaki H, Patel M, Rubinstein I. A novel formulation of VIP in sterically stabilized micelles amplifies vasodilation in vivo. Pharmaceutical Research 16:155-160, 1999.

Rubinstein I, Potempa J, Travis J, Gao-X-p. Mechanisms mediating Porphyromonas gingivalis gingipain RgpA-induced oral mucosa inflammation in vivo. Infection and Immunity 69: 1199-1201, 2001.

Dagar S, Sekosan M, Rubinstein I, Önyüksel H. Detection of VIP receptors in MNU-induced breast cancer in rats: implications for breast cancer targeting. Breast Cancer Research and Treatment 65: 49-54, 2001.

Dagar S, Sekosan M, Lee B-S, Rubinstein I, Önyüksel H. VIP receptors as molecular targets of breast cancer: implications for targeted imaging and drug delivery. Journal of Controlled Release 74: 129-134, 2001.

Rubinstein I, Pedersen GW. Bacillus species are present in chewing tobacco sold in the United States and evoke plasma exudation from the oral mucosa. Clinical and Diagnostic Laboratory Immunology 9:1057-1060, 2002.

Krishnadas A, Rubinstein I, Önyüksel H. Sterically stabilized phospholipid mixed micelles: in vitro evaluation as a novel carrier for water-insoluble drugs. Pharmaceutical Research 20: 297-302, 2003.

Corradi M, Rubinstein I, Apostoli P, Andreoli R, Goldoni M, Manini P, Vettori MV, Mutti A. Aldehydes in exhaled breath condensate of patients with chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine 167: 1380-1386, 2003.

Garey KW, Neuhauser MM, Robbins RA, Danziger LH, Rubinstein I. Markers of inflammation in exhaled breath condensate of young healthy smokers. Chest 125: 22-26, 2004.

Koo OM, Rubinstein I, Önyüksel H. Camptothecin in sterically stabilized phospholipids micelles: a novel nanomedicine. Journal of Nanomedicine 1: 77-84, 2005.

Sethi V, Önyüksel H, Rubinstein I. Liposomal vasoactive intestinal peptide. Methods in Enzymology 391: 377-395, 2005.

MEDLINE LINK