None. However, patient cooperation is essential. The patient must be able to take in a breath and hold it for at least 20 seconds. The patient will then be asked to rebreathe into a closed system for approximately 5 minutes. These requirements generally exclude patients on ventilators from receiving this study.
Xe-133 gas by inhalation (3 mCi/L) is used for a total dose of 20-30 mCi. The critical organ is the trachea (for a dose of 30 mCi, 6.4 rad).
With adequate patient cooperation, the study takes approximately 15 minutes.
A complete study includes recording 3 phases: single-breath view reflects regional ventilatory rate (if there is maximal inspiratory effort); the washout phase is more sensitive in detecting trapping secondary to airway obstruction (COPD). Regional quantitative estimates of function can be calculated for pre-op planning when requested.
NOTE: This study may be ordered on an emergency basis with the perfusion lung scan.