Clinical Interface Core (CIC)

Services Provided

CIC Services
How to apply for CIC services
Starting your study with CIC
Phlebotomy Instruction
Investigational Pharmacy
Study Coordinator
Dietary Services
Obtaining Research services within UIMCC
What Every Study Coordinator Wants to Know

CIC Services

The Clinical Interface Core (CIC) provides the UIC research community with a core of clinical research professionals with specific training that includes but is not limited to data collection; development of source documentation; adverse event reporting; protection of research subjects; orientation of other professionals to clinical research facilitation; and education of subjects regarding clinical research. The CIC nursing staff is comprised of individuals with advanced clinical knowledge and skills in the areas of critical care, pediatrics, and women's health.

For more information about the CIC nursing staff, please contact:

Lauren Castro at or Maryann Holtcamp at
(312) 996- 2937.

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How to apply for CIC services

Investigators who wish to access Clinical Interface Core (CIC) services initiate the process by contacting the CIC staff Lauren Castro or Maryann Holtcamp, by e-mail ( or or telephone (312-996-1926). Be prepared to provide a brief protocol summary and anticipated CIC services.

To download and review the application procedures and instructions; follow the below link.

>> Link to Application Page <<

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Starting your study with the CIC

Once your project has been approved by CIC leadership and by the UIC Institutional Review Board (IRB), you need to schedule a meeting with the CIC staff. This meeting is referred to as the protocol initiation meeting. The clinical staff (nursing staff, and the investigational pharmacist, if appropriate) meets with both the investigator and his/her study staff to discuss the operationalization of your study during this meeting.

Once all of the details of the study are discussed and agreed upon, the nursing staff develops a set of nursing guidelines, flow sheets, and physician orders specific for your protocol. The detailed nursing guidelines assume the data collection process in the CIC is consistent across subjects. We will ask the investigator to approve the final draft of these guidelines. Once the protocol initiation meeting is concluded, we ask that you give us at least 10 business days before the first subject is scheduled. This will give the CIC staff time to write the nursing and laboratory guidelines and order the supplies necessary for your study.

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The Clinical Interface Core offers an array of services to meet the individual needs of investigators. These include study coordinator services, clinical research nursing services, and ancillary charges (such as meals or specialty supplies) associated with the implementation of the research. Staff time may be charged on an hourly basis or by support of a percent of the staff member's position (% effort). A one-time administrative application fee of $2,000 will be assessed to all industry sponsored projects.

These expectations will be included in your Memorandum of Understanding with the Clinical Interface Core. For further information, please contact Lauren Castro at or Maryann Holtcamp at at 312-996-2937.

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Procedures that are performed by the CIC nursing staff include, but are not limited to:

  • Measurement of vital signs
  • Orthostatic blood pressures
  • Phlebotomy
  • Arteriopuncture
  • IV catheter insertion
  • Investigational drug infusions
  • Maintenance/titration of insulin drips
  • Medication compliance assessment
  • Timed pharmacokinetic studies
  • Collection of urine/other biological fluids over specified time periods
  • Subcutaneous fat biopsy (by APN)
  • Assistance with bone marrow biopsies
  • Oral Glucose Tolerance Tests
  • Intravenous Glucose Tolerance Tests
  • Fast-Sampling IV Glucose Tolerance Tests
  • Euglycemic Clamps
  • Insulin Clamps
  • Administration of questionnaires/surveys
  • Off-shift sample processing (Blood, saliva, etc.)
  • Assistance with the application of repetitive transcranial magnetic stimulation
  • Development of data flow sheets
  • Development of nursing guidelines
  • Moderate conscious sedation
  • Chemotherapy Infusions
  • Bioimpedance analysis
  • Spirometry
  • Allergy skin testing

If you have any additional questions about nursing procedures or services, please contact:

Lauren Castro at or Maryann Holtcamp at
(312) 996- 2937.

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The University of Illinois at Chicago CIC resources include a specimen processing laboratory and a radioisotope laboratory.

The UIC CIC Laboratory offers the following services:

  • Processing of research specimens including blood, urine, stool, sputum, and saliva
  • Point of Care Testing including blood glucose, hemoglobin, urine pregnancy, urine drug screen, urine dipstick
  • Specimen shipping in accordance with IATA regulations
  • Radioisotope laboratory facility available for radioisotope studies
  • Temporary sample storage including refrigeration, -20 C and , -80 C

CIC personnel can work with various outside labs to help investigators obtain the clinical analysis needed on research specimens. Each investigator creates an independent account and will receive custom requisitions with the lab of their choice. Laboratories commonly used by CIC investigators include:

Study Coordinators Guide to Laboratory Testing

For more information please contact:
Core Lab Director: Samuel Levin, PhD, DABCC  

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Phlebotomy Instruction

The CIC offers small group classes on a monthly basis. This single afternoon class is open to students that will work directly in clinical research and is taught by nurses in the Clinical Research Center. All students must have completed the UIC Bloodborne Pathogen training prior to participating in our training.

To register for the course, please complete this brief questionnaire.

Course objectives include:

  • Identify blood collection supplies and their proper use including types of needles, tourniquets, the Vacutainer system, blood collection tubes, and sharps containers.
  • Properly implement safety precautions to protect the phlebotomist and the patient, including standard precautions as introduced in Bloodborne Pathogen Training.
  • Demonstrate best practice in methods to help best identify an appropriate vein for venipuncture.
  • Verbalize understanding of arm anatomy and inappropriate sites to perform phlebotomy (AV fistula, mastectomy, paralysis, etc.)
  • Demonstrate steps of venipuncture using practice arm under guidance of instructor.
  • Identify potential complications of phlebotomy and management of the most common complications.
  • Complete five supervised phlebotomy attempts under guidance from Clinical Research Center staff.

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Investigational Pharmacy

The Investigational Drug Service at UIC Medical Center assures appropriate storage, handling, drug accountability, information access and compliance with standards which includes hospital policy, FDA, the Joint Commission and state and federal standards. It is required that an investigational pharmacist dispenses all pharmacy-related substances. Investigational drugs and study-related information are accessible around the clock and through out the year.

When supplied with an order from the study's physician, the Investigational Drug Service can order and receive drug shipments for the investigator.Study medications arriving after hours and on weekends will be handled by the service.

The Investigational Pharmacist provides the following services:

  • Proper drug storage (i.e., Temperature, light, moisture, security, etc)
  • Precise drug preparation
  • Proper dispensing of protocol-specific drugs
  • Ensure randomization and blinding procedures are followed
  • Maintain accurate records & inventory levels

For more information please contact:
Pacini, Michael J. Pharm D., Investigational Pharmacist

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Study Coordinators

Under the guidance of the CIC research nurses, study coordinators are available to assist principal investigators with research activities such as but not limited to study protocol initiation, subject recruitment, study follow-up, data collection, and study monitor coordination.

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Dietary Services

The Dietary Services offered through the CIC range from simply providing meals or snacks for research volunteers, to assisting in the planning and development of nutritional research study designs and protocols. A research dietician can assist with special diet preparation, preparation instructions, and patient dietary education services.

Investigators may request Dietary Services and/or resources from the CIC dietitian for inpatient and outpatient studies, whether performed in the CIC or off-site. Investigators are encouraged to discuss potential research needs with the dietitian during the proposal planning stage.

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