Steven J. Ackerman , Ph.D., Professor, Biochemistry
Molecular mechanisms of granulocyte (eosinophil) development, gene regulation, and function in health and disease. Structure/function relationships of cationic toxins, enzymes and other eosinophil protein mediators of inflammation and tissue damage.
Sylvie Blond-Elguindi , Ph.D., Assitant Professor, Microbiology and Immunology Affiliate
Structure and function of molecular chaperones.
R. Dale Brown , Ph.D., Assistant Professor, Pharmacology
Adrenergic receptor occupancy and signal transduction mechanisms regulating vascular smooth-muscle contraction.
Ananda M. Chakrabarty , Ph.D., Professor, Microbiology and Immunology
Plasmid molecular biology and gene regulation and nutritional versatility in microorganisms; plasmid-assisted degradation of toxic chemicals; Pseudomonas infection in cystic fibrosis patients.
Edward P. Cohen , M.D., Professor, Microbiology and Immunology
Therapy of melanoma with gene-modified cells; in vitro generation of specific cytoxic lymphocytes.
Rochelle S. Cohen , Ph.D., Professor, Anatomy and Cell Biology
Cell biological correlates of behavior; effects of the hormone estrogen on areas of the brain controlling rat female reproductive behavior.
Karen J. Colley , Ph.D., Assistant Professor, Biochemistry
Molecular basis for intracellular protein localization.
Robert Costa , Ph.D., Associate Professor, Biochemistry
Tissue-specific gene regulation; liver transcription factors; choroid plexus DNA control elements.
Richard L. Davidson , Ph.D., Professor and Head, Genetics
Mammalian somatic-cell genetics; regulation of gene expression; mechanisms of chemical mutagenesis; gene transfer.
Primal de Lanerolle , Ph.D., Associate Professor, Physiology and Biophysics
Cellular and molecular muscle physiology; regulation of cell motility; protein phosphorylation.
Ervin G. Erdös , M.D., Professor, Pharmacology
Vasoactive peptides that stimulate smooth muscle; renal enzymes that regulate blood pressure; metabolism of peptides by human lung converting enzyme.
Peter G.W. Gettins , D.Phil., Professor, Biochemistry
Structure and function of the serpin and alpha-2-macroglobulin families of plasma proteinase inhibitors; use of NMR and other spectroscopic methods to examine structure and conformational changes in solution.
Geula Gibori , Ph.D., Professor, Physiology and Biophysics
Reproductive endocrinology; regulation of ovarian and placental function; molecular mechanism of hormone action.
Richard D. Green , Ph.D., Professor, Pharmacology
Drug-receptor interactions; receptor-effector coupling; neuromodulatory role of adenosine in the striatum; development of receptor-effector systems; role of adenosine in regulating myocardial function.
Andrei V. Gudkov , Ph.D., Assistant Professor, Genetics
Identification of new recessive genes related to cancer including tumor suppressor genes, drug sensitivity genes and genes mediating virus infection.
Dale B. Hales , Ph.D., Associate Professor, Physiology and Biophysics
Molecular endocrinology; male reproductive function; regulatory mechanisms of Leydig cell steroid hormone biosynthesis; reproductive immunology and toxicology.
Heidi E. Hamm , Ph.D., Professor, Physiology and Biophysics
GTP-binding proteins; receptor G-protein coupling mechanisms; signal transduction; visual transduction in retinal photoreceptors; cellular neurobiology.
William Hendrickson , Ph.D., Assistant Professor, Microbiology and Immunology
Bacterial gene regulation and genomic structure; protein-DNA interactions; genomic mapping; biodegradation of environmental pollutants.
Yee-Kin Ho , Ph.D., Associate Professor, Biochemistry
Molecular mechanisms of phototransduction; biological coupling enzymes.
Lawrence Isaac, Ph.D., Professor, Pharmacology
Spinal cord injury-mechanisms of secondary injury; Stroke -pharmacologic formulations to halt and reverse neural injury; Memory disorders-behavioral, morphologic and molecular aspects; Neuron aging-molecular mechanisms of stress-and age-induced neuronal plasticity; Computer modeling-computer modeling of excitotoxicity.
Randal Jaffe , Ph.D., Professor, Physiology and Biophysics
Mechanisms of steroid hormone action; interaction of thyroid hormones with receptors and their role in growth and differentiation; hormonal control of gene expression.
Amy Kenter , Ph.D., Associate Professor, Microbiology and Immunology
Genetic mechanisms of immunoglobulin gene recombination; DNA-gilding proteins; B-cell-specific nucleic acid enzymes.
Stephen C.T. Lam , Ph.D., Associate Professor, Pharmacology
Role of platelet membrane glycoproteins as receptors for adhesive proteins; signal transduction mechanisms regulating platelet adhesive functions.
Lester Lau , Ph.D., Professor, Genetics
Control of cell growth and differentiation; regulation of gene expression in tissue culture cells and in transgenic mice; activities of growth factors.
Guy C. LeBreton , Ph.D., Professor, Pharmacology
Cardiovascular pharmacology: drug modulation of blood platelet function; role of calcium as an intracellular transmitter; arachidonic acid metabolism.
Xiubei Liao , Ph.D., Assistant Professor, Biochemistry
Heteronuclear multidimensional NMR spectroscopy structure and dynamics of macromolecules in solution; the structural and functional studies of HFH-2 DNA binding domain.
Anna Lysakowski , Ph.D., Assistant Professor, Anatomy and Cell Biology
Structure and function in the vestibular system.
Philip Matsumura , Ph.D., Professor, Microbiology and Immunology
Prokaryotic molecular biology; bacterial chemotaxis; protein structure and function.
Sergei M. Mirkin , Ph.D., Assistant Professor, Genetics
Unusual DNA structures and their role in DNA replication transcription and recombination.
Peter Moore , Ph.D., Associate Professor, Genetics
Recombination and mutagenesis in mammalian cells and cell-free systems.
Shigehiro Nakajima , M.D., Professor, Pharmacology
Cellular neurophysiology; electrophysiology of brain neurons in culture.
Yasuko Nakajima , M.D., Professor, Anatomy and Cell Biology
Signal transduction mechanisms of neurotransmitter effects; the ionic mechanisms of neurotransmitters in cultured dissociated neurons from specific brain nuclei.
Steven T. Olson , Ph.D., Associate Professor, Biochemistry Affilate
Molecular mechanisms of activation and regulation of blood coagulation and fibrinolysis; control of proteolysis by protein proteinase inhibitors.
George Pappas , Ph.D., Professor and Head, Anatomy and Cell Biology
Host graft interactions of CNS chromaffin cell implants.
Sergey V. Popov , Ph.D., Assistant Professor, Physiology and Biophysics
Membrane recycling and mechanisms of neuronal growth.
Mrinalini C. Rao , Ph.D., Associate Professor, Physiology and Biophysics
Regulation of water and electrolyte transport across epithelia; role of calcium and cyclic nucleotides; electrophysiological, pathophysiological, biochemical, and molecular studies.
Mark M. Rasenick , Ph.D., Professor, Physiology and Biophysics
Cellular neurobiology: neurotransmitter receptors; adenylate cyclase, GTP-binding proteins, and the cytoskeleton; cyclic nucleotides and cellular signal transduction.
Pradip Raychaudhuri , Ph.D., Associate Professor, Biochemistry
Interaction of nuclear oncoproteins with cellular transcription regulatory pathways.
Adrienne Rogalski-Wilk , Ph.D., Associate Professor, Anatomy and Cell Biology
Cell and molecular biology of novel plasma membrane-actin cytoskeletal systems.
Igor Roninson , Ph.D., Professor, Genetics
Molecular biology of cancer; targeted gene suppression.
Brenda Russell , Ph.D., Professor, Physiology and Biophysics
Molecular and subcellular mechanisms involved in muscle growth and adaptation; cardiac and skeletal.
Simon Silver , Ph.D., Professor, Microbiology and Immunology
Bacterial molecular biology; membrane transport; plasmid molecular biology; ATPases.
Randal A. Skidgel , Ph.D., Associate Professor, Pharmacology
Role of human carboxypeptidase M in activation or inactivation of several peptide hormones.
R. John Solaro , Ph.D., Professor and Head, Physiology and Biophysics
Physiology, biochemistry, molecular biology, and pharmacology of cardiac muscle contraction.
Robert V. Storti , Ph.D., Professor, Biochemistry
Gene regulation during cell differentiation; isolation, organization, and expression of muscle protein genes in Drosophila.
Angela Tyner , Ph.D., Assistant Professor, Genetics
Regulation of gene expression in the mouse intestine; intestinal stem-cell differentiation.
David Ucker , Ph.D., Associate Professor, Microbiology and Immunology
The molecular mechanism of physiological cell death.
James R. Unnerstall , Ph.D., Associate Professor, Anatomy and Cell Biology
Biochemical plasticity in aging; the noradrenergic locus coeruleus system.
Karl Volz , Ph.D., Associate Professor, Microbiology and Immunology
Protein engineering; X-ray crystallography of biologically active proteins.
William E. Walden , Ph.D., Associate Professor, Microbiology and Immunology
Mechanisms of eukaryotic translation regulation; protein-RNA interactions in gene regulation; genetic regulation of iron metabolism.
Cho-Yau Yeung , Ph.D., Assistant Professor, Genetics
Structure and function of mammalian gene promoters; transgenic animal models of human diseases.
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