Microbiology & Immunology for Dental MIM 322 - Fall '10

Course Director:                                 Bin He , Ph.D.
College of Dentistry Coordinators: Luisa DiPietro , DDS, PhD,  Phillip Marucha , DMD, PhD

Course Objectives:

Students obtain an overview of the varieties of microorganisms, particularly those commensal or pathogenic in man, identify major characteristics of the various categories of microorganisms.  The relationship of the structure and metabolism of microorganisms to their growth, function, and pathogenic potential are learned.  Students gain an understanding of the mechanisms of action of various categories of chemotherapeutic agents including antibiotics, and the potential for genetic change among microbes leading to antibiotic resistance and for human disease. 
Fundamental concepts of body’s immune defense mechanisms with emphasis on mechanisms of the body's immune resistance to infectious viruses, fungi, and pathogenic bacteria are taught.  Students learn to characterize microorganisms that cause human diseases including those that impact the field of dentistry, especially those involved in dental caries and periodontal disease. They gain an appreciation of current public health concerns in dentistry.

Textbook: Medical Microbiology and Immunology, Levinson, 10th edition; Lange. This is a medical review covering all relevant aspects of Microbiology & Immunology.  The review book combined with lecture handouts should be appropriate for this course.  The immunology section is poorly covered in the book. For a better knowledge of the topics covered in the syllabus, read below.

Two additional books are recommended for those students interested in a more comprehensive treatment of the subjects:

    1. Janeway's Immunobiology by Murphy, Travers, & Walport ; 7th Edition; Garland Science
    2. Medical Microbiology by Murray, Rosenthal,  & Pfaller; 5th Edition;  Elsevier  Mosby


No

DAY

DATE

TIME

ROOM

TOPIC 

LECTURER

1

M

Aug
23

9 AM

LHN

Overview-Microbiology, Immunology, and the Oral Cavity                          

Marucha

2

W

25

9 AM

330D

Introduction to Oral Ecology      

Tao

3

Th

26

11AM

LHN

Variety of microbes, Bacterial structure, Gram stain   

Chakrabarty

4

F

27

9 AM

LHN

Microbial Growth & Nutrition                             

Tao

5

M

30

9 AM

LHN

Microbial Nutrition & Metabolism                             

Tao

6

W

Sept

1

9 AM

330D

Microbial Genetics 1                

Tao

7

Th

2

11AM

LHN

Microbial Genetics 2                

Tao

8

F

3

9 AM

LHN

GROUP DISCUSSIONS           

Tao

9

W

8

9 AM

330D

Overview of microbial biofilms 

Wu

10

Th

9

11AM

LHN

Plaque Biofilm and Dental Caries                          

Wu

11

F

10

9AM

LHN

Dental Caries as an Infectious Disease                        

Tao

12

M

13

9AM

LHN

Viruses-classification                 

He

13

W

15

9AM

330D

Virus multiplication and pathogenesis                            

He

14

Th

16

11AM

LHN

Control of virus infection           

He

15

F

17

9AM

LHN

Fungi                                        

Tao

16

M

20

9AM

LHN

Spirochetes and protozoa          

Tao

17

W

22

9AM

330D

Microbial biofilms and periodontal diseases                 

Crawford

18

Th

23

11AM

LHN

Periodontal pathogens              

Crawford

19

F

24

9AM

LHN

Papillomaviruses                      

Bagchi

20

M

27

9AM

330D

Herpesviruses                         

He

21

W

29

9AM

330D

GROUP DISCUSSIONS           

He

22

Th

30

11AM

LHN

Mycobacteria, Actinomycetes & Mycoplasma             

Li, Q

23

F

1

9AM

LHN

No Class           

 

24

M

4

9AM

LHN

Haemophilus, Bordetella, & Legionella    

Freitag

25

W

6

9AM

330D

Chlamydiae, & Rickettsiae                                   

Freitag

26

Th

7

11AM

LHN

Neisseria, Bacillus, clostridium      

Freitag

27

F

8

9AM

LHN

Corynebacterium, Listeria & Zoonotic organisms   

Freitag

28

M

11

9AM

LHN

Enterobacteriaceae     

Chakrabarty

29

W

13

9AM

330D

Hepatitis viruses                      

Rong

30

Th

14

11AM

LHN

Retroviruses and HIV                 

Rong

31

F

15

9AM

LHN

Mumps, Measles, Rubella and Coxsackie viruses         

Rong

32

M

18

9AM

LHN

Mode of action of antibiotics    

Federle

33

W

20

9AM

330D

Mechanisms of antibiotic resistance                                

Federle

34

Th

21

11AM

LHN

Sterilization & Disinfection        

Li, Q

35

F

22

9AM

LHN

Staphylococci & Streptococci                 

Federle

MONDAY, OCTOBER 25 - EXAM 1 (LECTURES 1-35) ROOM LHN

36

W

27

9AM

330D

Overview of the immune system                                     

Prabhakar

37

Th

28

11AM

LHN

Innate Immune System – Inflammation I                        

DiPietro

38

F

29

9AM

LHN

No Class                   

 

39

Nov 1  

9AM

LHN

Innate Immune System – Inflammation Il                           

DiPietro

40

W

3

9AM

330D

Complement             

DiPietro

41

Th

4

11AM

LHN

Type I hypersensitivity               

Chen

42

F

5

9AM

LHN

Type II, III, and IV hypersensitivity                       

Chen

43

M

8

9AM

LHN

MHC Complex and It’s Functions                                

Volz

44

W

10

9AM

330D

Antigen Recognition and Presentation to T Cells             

Volz

45

Th

11

11AM

LHN

Acquired Immunity - Antigens & Antibodies                                

DiPietro

46

F

12

9AM

LHN

Then Humoral immune Response                 

DiPietro

47

M

15

9AM

LHN
Immune tolerance and transplantaion            

Chen Z

48

W

17

9AM

330D

Tumor immunology           

Li, J

49

Th

18

11AM

LHN

GROUP DISCUSSION     

Prabhakar

50

F

19

9AM

LHN

Vaccine and immunotherapy   

Li, J

51

M

22

9AM

LHN

Immunodeficiency                   

Marucha

52

W

24

9AM

330D

Autoimmunity                        

Cohen

53

M

29

9AM

LHN

Musocal immunity            

DiPietro

54

Dec
1

9AM

330D

T cell mediated Immunity I

Bouvier

55

Th

2

11AM

LHN

T cell mediated Immunity II

Bouvier

56

F

3

9AM

LHN

Immunology review                   

Prabhakar

MONDAY, DECEMBER 13, 10:00 - 12:00 -FINAL EXAM -LHS