Inventions

(the patents are owned by the University of Illinois at Chicago and acknowledge support from both NIH and CDG Therapeutics, Inc, as appropriate)

  1. US Patent application Serial NO. 11/488,695 Transport Agents for crossing the blood-brain barrier and into brain cancer cells, and methods of use thereof.
  2. US Patent Application Serial No. 11/436,592 Compositions and methods for treating conditions related to ephrin signaling with cupredoxin.
  3. US Patent Application Serial No. 11/436,590 Compositions and methods for treating malaria with cupredoxin and cytochrome.
  4. US Patent Application Serial No. 71/244,105 Compositions and methods to control angiogenesis with cupredoxins.
  5. US Provisional Patent Application Serial No. 60/872,471 Compositions and methods to treat cancer with cupredoxins and CpG DNA.
  6. US Patent Application Serial No.  11/854,654 Compositions and methods to prevent cancer with cupredoxins.

Patent issued

  1. A. M. Chakrabarty, Das Gupta, TK, Punj, V, Zaborina O. Cytotoxic factors for modulating cell death.  US Patent 7,084,105 issued on August 1, 2006.
  2. A.M.Chakrabarty, Das Gupta TK, Yamada T, Chaudhari A, Fialho A, Hong CS. Compositions and methods for treating HIV infection with cupredoxins and cytochrome c.  US Patent 7,301,010 issued on November 27, 2007.

Publications

  1. Fialho AM, Das Gupta TK, Chakrabarty AM. Promiscuous drugs from pathogenic bacteria in the post- antibiotics era. In Patho-Biotechnology (Roy Sleator and Colin Hill, Eds), Landes Bioscience, Austin, TX, 2008 (in press).
  2. Naguleswaran A, Fialho AM, Chaudhari A, Hong CS, Chakrabarty AM, Sullivan, Jr. WJ. Azurin-like protein blocks invasion of Toxoplasma gondii through potential interactions with parasite surface antigen SAG1. Antimicrob Agents Chemotherap 2008, 52, 402-08.
  3. Kolli BK, Kostal J, Zaborina O, Chakrabarty AM, Chang KP. Leishmania-released nucleoside diphosphate kinase prevents ATP-mediated cytolysis of macrophages. Molec. Biochem. Parasitol. 2008, in press.
  4. Fialho AM, Chakrabarty AM. Recent patents on bacterial proteins as potential anticancer agents. Rec.  Patents Anti-Cancer Drug Discov. 2007, 2, 224-34.
  5. Chaudhari A, Mahfouz M, Fialho AM, Yamada T, Granja AT, Zhu Y, Hashimoto W, Schlarb-Ridley B, Cho W, Das Gupta TK, Chakrabarty AM. Cupredoxin-cancer interrelationship: Azurin binding with EphB2, interference in EphB2 tyrosine phosphorylation, and inhibition of cancer growth. Biochemistry, 2007, 46, 1799-810.
  6. Fialho AM, Stevens FJ, Das Gupta TK, Chakrabarty AM. Beyond host-pathogen interactions: Microbial defense strategy in the host environment. Curr. Opin. Biotech., 2007, 18, 279-85.
  7. Mahfouz M, Hashimoto W, Das Gupta TK, Chakrabarty AM. Bacterial proteins and CpG-rich extrachromosomal DNA in potential cancer therapy.  Plasmid, 2007, 57, 4-17.
  8. Fialho AM, Das Gupta TK,  Chakrabarty, AM.  Designing promiscuous drugs?  Look at what nature made!  Lett. Drug Design Discov.,  2007, 4, 40-3.
  9. Hong CS, Yamada T, Hashimoto W, Fialho AM, Das Gupta TK, Chakrabarty AM.  Disrupting the entry   barrier and attacking brain tumors: the role of the Neisseria H.8 epitope and the Laz protein. Cell Cycle, 2006, 5, 1633-41.
  10. Chaudhari A, Fialho AM, Ratner D, Gupta P, Hong CS, Kahali S, Yamada T, Haldar K, Murphy S, Cho W, Chauhan VS, Das Gupta TK, Chakrabarty AM.  Azurin, Plasmodium falciparum malaria and HIV/AIDS:  inhibition of parasitic and viral growth by azurin.  Cell Cycle, 2006, 5, 1642-8.
  11. Hiraoka Y, Granja AT, Fialho AM, Schlarb-Ridley BG, Das Gupta TK, Chakrabarty AM, Yamada T. Human cytochrome c enters murine J774 cells and causes G1 and G2/M cell cycle arrest and induction of apoptosis.  Biochem. Biophys. Res. Commun. 2005, 338, 1284-90.
  12. Yamada T, Fialho AM, Punj V, Bratescu L, Gupta TK, Chakrabarty AM.  Internalization of bacterial redox protein azurin in mammalian cells: entry domain and specificity.  Cell. Microbiol. 2005, 7, 1418-31.
  13. Yamada T, Hiraoka Y, Das Gupta TK, Chakrabarty AM.  Rusticyanin, a bacterial electron transfer protein, causes G1 arrest in J774 and apoptosis in human cancer cells.  Cell Cycle, 2004, 3, 1182-7..
  14. Yamada T, Hiraoka Y, Das Gupta TK, Chakrabarty AM.  Regulation of mammalian cell growth and death by bacterial redox proteins: relevance to ecology and cancer therapy.  Cell Cycle, 2004, 3, 752-5.
  15. Hiraoka Y, Yamada T, Goto M, Das Gupta TK, Chakrabarty AM.  Modulation of mammalian cell growth and death by prokaryotic and eukaryotic cytochrome c.  Proc. Natl. Acad. Sci. U S A. 2004, 101, 6427-32.  
  16. Yamada T, Hiraoka Y, Ikehata M, Kimbara K, Avner BS, Das Gupta TK, Chakrabarty AM.  Apoptosis or growth arrest: Modulation of tumor suppressor p53's specificity by bacterial redox protein azurin.  Proc. Natl. Acad. Sci. U S A. 2004, 101, 4770-5.
  17. Punj V, Bhattacharyya S, Saint-Dic D, Vasu C, Cunningham EA, Graves J, Yamada T, Constantinou AI, Christov K, White B, Li G, Majumdar D, Chakrabarty AM, Das Gupta TK.  Bacterial cupredoxin azurin as an inducer of apoptosis and regression in human breast cancer.  Oncogene. 2004, 23:2367-78.
  18. Punj V, Das Gupta TK, Chakrabarty AM.  Bacterial cupredoxin azurin and its interactions with the tumor suppressor protein p53.  Biochem. Biophys. Res. Commun. 2003, 312:109-14.
  19. Chakrabarty AM.  Environmental biotechnology in the postgenomics era.  Biotechnol. Adv. 2003, 22:3-8.  
  20. Chakrabarty AM.  Crossing species boundaries and making human-nonhuman hybrids: moral and legal ramifications.  Am. J. Bioeth. 2003, 3:20-1.
  21. Punj V, Sharma R, Zaborina O, Chakrabarty AM.  Energy-generating enzymes of Burkholderia cepacia and their interactions with macrophages.  J. Bacteriol. 2003, 185:3167-78.
  22. Chakrabarty AM.  Microorganisms and cancer: quest for a therapy.  J. Bacteriol. 2003, 185:2683-6.
  23. Punj V, Chakrabarty AM.  Redox proteins in mammalian cell death: an evolutionarily conserved function in mitochondria and prokaryotes.  Cell. Microbiol. 2003, 5:225-31.  
  24. Chakrabarty AM.  Patenting life forms: yesterday, today, and tomorrow.  Adv. Genet. 2003, 50:3-11.
  25. Ogawa N, Miyashita K, Chakrabarty AM.  Microbial genes and enzymes in the degradation of chlorinated compounds.  Chem. Rec. 2003, 3:158-71.  
  26. Goto M, Yamada T, Kimbara K, Horner J, Newcomb M, Gupta TK, Chakrabarty AM.  Induction of apoptosis in macrophages by Pseudomonas aeruginosa azurin: tumour-suppressor protein p53 and reactive oxygen species, but not redox activity, as critical elements in cytotoxicity.  Mol. Microbiol. 2003, 47:549-59.
  27. Yamada T, Goto M, Punj V, Zaborina O, Kimbara K, Das Gupta TK, Chakrabarty AM.  The bacterial redox protein azurin induces apoptosis in J774 macrophages through complex formation and stabilization of the tumor suppressor protein p53.  Infect Immun. 2002, 70:7054-62.
  28. Yamada T, Goto M, Punj V, Zaborina O, Chen ML, Kimbara K, Majumdar D, Cunningham E, Das Gupta TK, Chakrabarty AM.  Bacterial redox protein azurin, tumor suppressor protein p53, and regression of cancer.  Proc. Natl. Acad. Sci. U S A. 2002, 99:14098-103.
  29. Chakrabarty AM.  Ethics in biomedical research: practical considerations.  Am. J. Bioeth. 2002, 2:53-4.
  30. Chakrabarty AM.  Compulsory licensure: the case of Cipro and beyond.  Am. J. Bioeth. 2002, 2:40.
  31. Chakrabarty AM.  Genetics research and the judicial decisions.  Not. Polit. 2002, 18:99-102.
  32. Markaryan O, Zaborina V, Punj and A.M. Chakrabarty.  Adenylate kinase as a virulence factor of Pseudomonas aeruginosa.  J. Bacteriol. 2001, 183: 3345-52.
  33. Punj V, Zaborina O, Dhiman N, Falzari K, Bagdasarian M, Chakrabarty AM.  Phagocytic cell killing mediated by secreted cytotoxic factors of Vibrio cholerae.  Infect. Immun. 2000, 68: 4930-37.
  34. Zaborina O, Dhiman N, Chen ML, Kostal J, Holder IA, Chakrabarty AM.  Secreted products of a nonmucoid Pseudomonas aeruginosa strain induce two modes of macrophage killing: external ATP-dependent, P2Z receptor-mediated necrosis and ATP-independent, caspase-mediated apoptosis.  Microbiolgy, 2000, 146: 2521-30.
  35. Melnikov M, Zaborina O, Dhiman N, Prabhakar BS, Chakrabarty AM, Hendrickson W.  Clinical and environmental isolates of Burkholderia cepacia exhibit differential cytotoxicity towards macrophages and mast cells. Mol. Microbiol. 2000, 36: 1481-93.
  36. Kamath S, Chen ML, Chakrabarty AM.  Secretion of nuceloside diphosphate kinase by mucoid Pseudomonas aeruginosa 8821: involvement of a carboxy-terminal motif in secretion.  J. Bacteriol., 2000, 182: 3826-31.
  37. Kapatral V, Bina X, Chakrabarty AM.  Succinyl-CoA Synthetase of Pseudomonas aeruginosa with a broad specificity for nucleoside triphosphate (NTP) synthesis modulats specificity for NTP synthesis by the 12 kDa form of nucleoside diphosphate kinase. J. Bacteriol. 2000, 182: 1333-39.
  38. Tover, Zernant J, Chugani SA, Chakrabarty AM, Kivisaar M.  Study of the critical nucleotides in the interaction of CatR with the pheBA promoter: conservation of the CatR-mediated regulation mechanisms between the pheBA and catBCA operons.  Microbiology 2000, 146: 173-183.
  39. Ogawa N, McFall SM, Klem TJ, Miyashita K, Chakrabarty AM.  Transcriptional activation of the chlorocatechol degradative genes of Ralstonia eutropha NH9. J. Bacteriol. 1999, 181: 6697-705.
  40. Mukhopadyay S, Kapatral V, Xu W, Chakrabarty AM.  Characterization of a Hank’s type serine/theonine kinase and serine/threonine phosphoprotein phosphatase in Pseudomoonas aeruginosa. J. Bacteriol. 1999, 181: 6615-22.
  41. Zaborina O, Misra N, Kostal J, Kamath S, Kapatral V,  El-Azami El-Idrissi M, Prabhakar BS,  Chakrabarty AM.  P2Z independent and P2Z receptor mediated macrophage killing by Pseudomonas aeruginosa isolated from cystic fibrosis patients. Infect. Immun. 1999, 67: 5231-42.
  42. Fakhr M, Penaloza-Vazquez A, Chakrabarty AM, Bender CL.  Regulation of alginate biosynthesis in Pseudomonas aeruginosa pv. syringae. J. Bacteriol. 1999, 181: 3478-85.
  43. Yu J, Penaloza-Vazquez A, Chakrabarty AM, Bender CL.  Involvement of the exopolysaccharide alginate in the virulence and epiphytic fitness of Pseudomonas syringae pv. syringae. Mol. Microbiol., 1999, 33: 712-720.
  44. Zaborina O, Li X, Cheng G, Kapatral V, Chakrabarty AM.  Secretion of ATP-utilizing enzymes, nucleoside diphosphate kinase and ATPase, by Mycobacterium bovis BCG: sequestration of ATP from macrophage P2Z receptors? Mol. Microbiol. 1999, 31: 1333-43.
  45. Zago A, Chugani S, Chakrabarty AM.  Cloning and characterization of polyphosphate kinase and expolyphosphatase genes from Pseudomonas aeruginosa 8830.  Appl. Environ. Microbiol. 1999, 65: 2065-71.
  46. Kamath S, Kapatral V, Chakrabarty AM.  Cellular function of elastase in Pseudomonas aeruginosa: role in the cleavage of nucleoside diphosphate kinase and in alginate synthesis. Mol. Microbiol. 1998, 30: 933-941.
  47. McFall SM, Chugani SA, Chakrabarty AM.  Transcriptional activation of the catechol and chlorocatehol operons: variations on a theme.  Gene 1998, 223: 257-267.
  48. Chakrabarty AM.  Nucleoside diphosphate kinase: role in bacterial growth, virulence, cell signaling and polysaccharide synthesis. Mol. Microbiol. 1998, 28: 875-882.

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