Born in Germany, he moved quickly in medical circles to work with Ludwig Edinger in the famous Senckenberg Patologisches Institut in Frankfurt-am-Main where he was also influenced by Carl Weigert in staining techniques. He did stellar work on the pathology in disseminated sclerosis and then began his fundamental studies on the silver impregnation of nerve fibers. He truly replaced Santiago Ramon y Cajalís (1852-1934) method on which it was based. Although he was a fine clinician he is known as a superior neuropathologist with his contributions in the study of tuberous sclerosis, amaurotic family idiocy (late infantile type) herpes Zoster, paralysis agitans, Huntingtonís chorea and myotonia congenita. He prepared the ground for so many neuropathologists to follow.

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