Born in Ireland (Dundalk) in 1876, Holmes emerged as one of the great clinical neurologists in this discipline. He performed classic research on the localization of function in the cerebellum. In 1904, together with Grainger Stewart, they wrote a paper in precise localization of destructive lesions in the cerebellum. He published considerably on the symptoms of expanding lesions, on disturbances of vision (chiefly caused by cerebral lesions) with special attention drawn to the critical representation of the macula and visual orientation. His name appears in syndromes and signs of cerebellar disturbance.

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